MIR6891: MIR6891 is an RNA gene that belongs to the miRNA class [PMC9569480]. It is located on chromosome 6 and is associated with other genes such as HLA-B, LOC101929072, MICA, LINC01149, HCP5, HCG26, MICB, MCCD1, and DDX39B [PMC9746098]. Several SNPs have been identified for MIR6891 and other miRNAs [PMC7044681]. There is a link between locus 6p21 and IgA levels through the association of rs3131294 with serum IgA levels [PMC9584840]. The risk allele A of rs3131294 is associated with increased expression of MIR6891 in whole blood and lung tissues [PMC9584840]. Rs3131294 also affects the expression of several COVID-19 candidate genes including AGER, complement system genes (C4A, C4B, CFB), antigen-processing genes (MHC class II genes), and NOTCH4 [PMC9584840]. MIR6891 is also identified as one of the vagina-specific eQTL-related genes [PMC8407429]. Rs2523589 has an impact on the expression levels of multiple candidate genes including MIR6891 in GTEx data [PMC7733486]. The location of MIR6891 within an HLA-B intron suggests a possible link between miR-6891-5p expression and HLA-B gene regulation [PMC9641602]. Rs4285314 presents a challenge in distinguishing its effect from that of HLA-B variants within the same susceptibility locus as MIR6891 variants [PMC10061723]. Experimental validation is needed to confirm predicted changes in MIR6891 and other target genes due to limitations in microRNA-target prediction algorithms [PMC10061723]. The seed SNP rs2276448 within MIR6891 has potential regulatory effects on its target function compared to other SNPs within the microRNA sequence regions [PMC10061723]. The association between MIR6891 and macrophage-driven inflammation suggests a potential role in MS [PMC10061723].