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Homo sapiens (human) TSPEAR antisense RNA 1 (TSPEAR-AS1) URS000075E4C3_9606

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TSPEAR-AS1: TSPEAR-AS1 is a long non-coding RNA (lncRNA) that functions as a competing endogenous RNA (ceRNA) by sponging miR-424 to regulate the expression of G protein subunit alpha L (GNAL) [PMC7180394]. It has been identified as an independent prognostic biomarker for overall survival (OS) in papillary thyroid carcinoma and lung adenocarcinoma [PMC7180394]. In addition, TSPEAR-AS1, along with other lncRNAs such as LINC00511, LINC01136, MKLN1-AS, LINC00506, KRTAP5-AS1, ZNF252P-AS1, and THUMPD3-AS1, has been found to be significant in the multivariate analysis and may serve as independent prognostic biomarkers [PMC7180394]. TSPEAR-AS1 has also been implicated in hepatocellular carcinoma (HCC) associated with hepatitis B virus (HBV), where it is suggested to have a protective role by coexpressing with MC1R [PMC7180394]. Furthermore, TSPEAR-AS1 is associated with chromosome 21 open reading frame 90 (C21orf90), indicating an interaction between these two genes [PMC8027719]. In terms of survival analysis for tongue squamous cell carcinoma (TSCC), TSPEAR-AS1 is identified as one of the ten lncRNAs that serve as prognostic biomarkers [PMC6368841]. Finally, high expression of TSPEAR-AS1 has been associated with shorter survival time in various cancers such as hepatocellular carcinoma and tongue squamous cell carcinoma [PMC9482270].

Genome locations

Gene Ontology annotations

Sequence

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GUGAGGUCAGCGGCCGUGAGGUCACUCCAGGAGGUGCCUACAGGACCUGCAGGACCUGCUCGUUCACAGAUGUUCUCCUAGAAGCAGAAGCUGUUUCUUGUUGCAAACAAAUUUGCUGUGUCCUGUCUUAGGAGUCUCACCUGAAUUUACCAAGGAUGCAUCUGUGCUUGGGGAUGGCUCGGUUUGAGGGGUCUGAGGAGCGGCUCCCCUGGAUCCUUUCCUCCCCAGGAGCCCACCUGCCGAGCUGUCAGCGUCAGCCCCACAUCUCAAGAUGAGGAAAUGGAGCCCGUGCCAGCUCGCUGGGAGGAGGACGAGGACGCCUGUGAUCACAUGCUCUGGUCUGGAGGCACGGCCGCGGGCCCCGGGUCAGUGUGAAUCCGCGGGGUUACUCCUCAGUCGGAUCUGAGCUCUGAAACCCAGACCCGAGGAAGACAAGCGGCCACGUCGGAUGUACCAGUGGUGGAAGAUCCUGUCCGGCUGCACCGAGGCUCACAUCAGAAGCCGGCUUCGGUUUCACCACAAAAUAAGGCAUCUAGUGCCCGAUUCUGCCUCCAAAGCAGCCCUGGGUCACACUCGCUGUAGGACAGAUGUUAUUCUUCAGAAUCACGCCCUCUGGCAAAUGCCCAUCAUCGGACAAAUGGACGGAUGAAGUGUGACUCAGCCAUGAGAAGGGGGAUGCUCUGAGCCGCGCGGCCACACCACCAACCCGGAGGACACGGUGCUGCGAGAAAAAGCCAGCCAGGAGUUCAGAAGUAACAGGGCAAAUAGGGAAAGUCCUUCCUGGCCUGUCUACAUACCCCUGCAGCCCUCCCGGUCCUAGGGUGACUGCUGACGGAGAGGGCACUCCCUUCCCGAGUCUUCUCUGCACGUCCGUGGGCACGCACAGCUGAGCGGCACACAGCAGCCCGGCUCGCUCCUCCGCACUGGGGACACAAGAUUUCACUGCACCUCACCCAGCCCUUUCCACAGAGCAGUUCAUCUUGGAGACUCUUCCCCUCGAAGGGUCUAAAGGCCAGUCUCCGUGUCCUGGUGUUUGUUGUCGGGGAGGAUGCAACAUCGGGGGAAGGAAGUAAUCAUGUCUGGUGGCAGCUGGCACUGGCAGGCAGCGGGCACUCGAAGCCUGCACCUCGCACCUGUCCCUCUGGGGCCUCGGCUAUCCCUCCGCACGACGGGCAUGAAGCCCCCUCCUGCCUCCACUGCUCGGAUGAAAGGAGCUCGUAGAUGACGGAGUUGAUGACAUAGGAAUCAUUCUGGACUUGCAUCUCCACAUCGUAGCUGUGACUGUUUGCCACAGCGAGGAAGAUCCUCUCCCCGAUCUGGAAGACCUCCCAGUCUGCAGCACCGAACGUCUAGGACCAAAGGAGAGCAGGCCCCAGUGCUGUGCGUCCUACGAGCACCACCUGCUGUCUCACCUCUUCCAGGAAGCCCACCCUGAUCCCUCUAGUCCCAGCCUCAGACACUGAAGCAACAUCAGGCGGAUGUCACCCACCCCUUGGGACUUCGCCAUGGGUCGCUAGCCCAGACCCUCCCCUUGGUUCCGGUGGUUCCAUUUCUGCCCCUUUGCUGCUGGCCCCCUUCUGAGGAUGCCCGUGCAUCUCCAGGACCACUGCUCCAGUCCUUGGUGUAGAUCAAAGCUGGCCUUCACACGCGGCCUGAAAAUGUAGAGUGGCCGCCUUCUGGGCUGGGCUGCCACCUCCACCACAUCACCCGUGACAGAAGCCCCGUGUUUUUCGGUAACCACGUUCCACGAACACCUCCCGACUGCCUUCCAGAACACACAAAGAUCAACGAAGCUCAGAAUCCAGUCCCGACGUCAUUUCAUGAAGAGCAGGUAGUCCAUCAAAGGGAUGGGCCCCAUGAGUGAAGGGCUGAGACCCCACCAUGGUGUGAGGCGUCCCAGGCACUCCCGUCACGGCCCAAACCAGGCUGCAGGCUCCAUCCCCAUGGGGCAGGCACAGAGGAGGCGAUUCAUGUGGACACAGGGACACCUGUGGACGCCCUGGCUCGGCCGCUUACCGCCGUGUGUUUGUGGCCAGGUCCCUGCUCCUGAGCCUCAGUUUCCACACCUGUGAGAUGGGUCUGAGGUGGAAUCGCCAACCAGCUGAGGAUGCGCAGCCACAGACCACCUUCCAGAAAUCUCCAAAAGGCUUUCCAAAACAGGAAAACAAGGAAGGCUGCCAUCAGCAGGAAUUCCAGGGCUUUCAGAAUGAGGCUGUCAGGAGUGAAGGGAGCUGUGCUCCACAUGCAGGGCAGUGGCCAGGGCUGCCAGGCCUUGUUUAUCUGGGAGCGCCAGGCUGCCUGCCUGCACCUGGUCUGGGCACCUGAAGGCAGAGCUGCUCCUGCUUAGGGUCUGUGGCAACUGUCCUCCUCAGUGGGUGCUGCUGGGAGCUCCUCUGAUUCCUGGUGGGCGGCUUCUGGCCUCGCCUCUUCACCCACGGUGUAGGGUGUGGGAUGGAGAUGCAGGGCCUCUGCUCUCCUUCUCCCCUCCCCCAAGCAGCCUGGGUUGUACCUCCACUAAUAAACACCAACACCCGCGCCCAGGGUGGGUUCGGC

Taxonomic tree

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Publications