v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) DPH6 divergent transcript (DPH6-DT) URS000075E4A5_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

DPH6-DT: DPH6-DT is a long non-coding RNA (lncRNA) that has been identified as a potential signature for indicating differentiation and uncovering the molecular mechanism in thyroid cancer (TC) [PMC8909347]. It has been found that DPH6-DT can promote TC progression by activating the PI3K-AKT signaling pathway, which is important for early diagnosis and therapy in anaplastic and RAI-refractory TC patients [PMC8909347]. In vitro experiments have shown that downregulation of DPH6-DT leads to increased expression of vimentin and N-cadherin during epithelial-mesenchymal transition (EMT), as well as enhanced invasion and migration [PMC8909347]. Additionally, DPH6-DT downregulation promotes proliferation and metastasis by activating the PI3K-AKT signaling pathway [PMC8909347]. The expression level of DPH6-DT is significantly upregulated with an increase in differentiation degree in TC [PMC8909347]. Furthermore, DPH6-DT has been identified as one of the prognostic related DR-lncRNAs with strong prognostic value in TC patients [PMC8909347]. The depletion of DPH6-DT increases AKT, p-AKT, and PI3K expression levels in TC cells [PMC8909347]. Knocking down DPH6-DT leads to increased cell viability and proliferation in TC cells [PMC8909347]. Overall, further studies are needed to explore the role of DPH6-DT and related pathways in differentiation using in vivo experiments [PMC8909347]. Reference: [PMC8909347] Liang J et al. (2021) Identification of Differentiation-Related Long Noncoding RNA Signature for Thyroid Cancer. Front Genet. 12: 638638. doi: 10.3389/fgene.2021.638638.

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
CGCCGCAGCUCGCGUGACGCACCGCGGGGCCUCGCCCGGGUGUUCGCUCCGCCGCCUGUCCGCGGAUCGGCGCUGCGAGCCCCGCGGCUGCCUGCGGGACACCUGAGCGCGGAGGGUGCGGCACCUUGGCACCUUGACCCUGUGGCAGGGACAUCUCGGCCCAGGAAAGAAUGAGGUUUAGGCACGGCCUAACCACCUAAGUGAGGGCACUGAAGCUGCCGGGGGAAGGGCAAGGUCCGCGUUGCAGAGCCCAAGCCCAGUGGCGCAGGAUUUGUUUUGGUCUCAGUUUGCUUCAUCUCUGGAAUGGAGAUGGUUUCCUAUGUGAUCAUGAAAAUUUCUCCCAGCUCUGAAGACCUUUUAUUUUGUAAGAAUCAUUGUGAAGGUAUGGGCUUGGCAAAUGAAUGGAAAGAUGAGCAAUGGGAGAGGAAAGAAUUGAAGAGGGCUGUGAGGUUUGAAGAAUGGCAUCCCCCAUGAAGUGGCGCUGAAAGAUCACGAUAGCACAGUUCCAUGAUGUGAAAUACCACAAGUCUGCAAUUUUUCGGUCUUGAGAGUGUCGCUGGGCUGAGAGGAUGGAAAUCUUUCAGUAAUUAUACCAGUUUGUAUUCGUCUCACAUUUGGGACCAAAUACAAAUCCGAUCCACUCUUUCUCCCUGUGAAUAUUCAUAAAAAACAAAGUGCCAAUUCUGGUCUAAUCAUGUAUGGAACCAAAUAUGUUGAUGAGUCCUAAGUAUAUACUGUAUGUAUGUAUACAUAUGAAUAUAUAUAUUUGUACACACUAAUUUUGCUUGUGUCCUCCUCUGUGCAAUUUGUUUGUUUAGUAUAGGGGUUGCUGUUAUAAUGUGUUAAUAAGCUGCUGAAAGCUUGGCACCUAUUACUUGAAAUGACAGCUAUGUUAGAAGCCUAUUAACACUCCAUAGCAGCAGCUCUGCAGCUACUAGAAAUGAAUUUCAAAGAAGGUAAAUGAACAAAAGCGAUUCAUAUCUCUAAGGAAAGCAAAUACCAUGCCUAGAACCAUAUAUACUUUGGAAAUGUACAGUGUAUAAAAUGAAAAACCUCUUCCAGUUAAAGAAACAGCGGAAGGGAAUAUUUGGGGAAAGGAAGACUGCCUAAAAGAUUUCCAAACAACCUUGAAGAUGUAAAUGUAAAGGAUACCAAACAUAACUUCCUCUCUUUGUUUCUAUUGUAUUUAAACCAGAUCCAUGUCAAACUUAUAAGAACAGAAUAUAGUACAGGUAGAGGAAAUUCACUUUUCAUGAGCAAAAGUUAAAUCAUCUGGAUUUAGCUCAAACUUCUUUUUCUUCAUUUCUGAGCUUAGAAGGACACCCUUUGCUAUUGUUCUCGGAAGCAGGGCUCUUUAUGAGUCAGCUUGCUCUGCUUUUGAACUACUUUACUUACUUUUGACUGUCAUUGGAAUUUGCAAGAUGGUUGAAAGUCCUGGGUAAACCUUAACCAUGAUAAUAAAAAUGUGGUAAGUUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications