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Homo sapiens (human) BDNF antisense RNA (BDNF-AS) URS000075E443_9606

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BDNF-AS: BDNF-AS, which stands for brain-derived neurotrophic factor antisense RNA, is an antisense transcript to BDNF and negatively regulates BDNF levels both in vivo and in vitro [PMC8609388]. A recent study found that upregulation of BDNF-AS is associated with a significant decrease in BDNF expression and increased recruitment of EZH2, which leads to repressive acetylation of lysine 27 on histone H3 protein subunit (H3K27) trimethylation (H3K27me3) at regulatory regions in the BDNF gene [PMC9886842]. Overexpression or knockdown of miR-125a/b-5p did not affect the expression of BDNF-AS [PMC8722203]. An Alu element sequence in the 3'-UTR of RAX2 and another Alu sequence in BDNF-AS were found to have a binding site with each other [PMC6997171]. Overexpression of PABPC1, BDNF-AS, and DLG5 along with depletion of RAX2 inhibited malignant biological behaviors of glioblastoma cells [PMC6997171]. When FBXW7 was overexpressed in the BDNF-AS-overexpressing mouse model, ferroptosis was increased, partially reversing the carcinogenic effect of BDNF-AS [PMC8898362]. It has been suggested that both BDNF and BDNF-AS SNPs may influence cognitive functions, but further research is needed to understand their roles in memory and learning performance [PMC5372667]. BDNF-AS has been found to have a direct physical interaction with EZH2 [PMC4576503], and its silencing has been shown to upregulate BDNF expression and cell viability while inhibiting apoptosis in neurotoxicity models [PMC8371338]. BDNF-AS is upregulated in ketamine-injured mouse embryonic neural stem cell-derived neurons, while BDNF is downregulated [PMC6079265]. In neonatal brain injury, the role of BDNF-AS is still not well understood [PMC7307822]. Silencing of BDNF-AS has been shown to have beneficial effects on cell viability, oxidative stress, and apoptosis through negative modulation of BDNF [PMC8964039]. Anxiety levels were not significantly different between BDNF-AS knockout and wild type mice [PMC8327352]. Additionally, BDNF-AS has been found to reduce bupivacaine-induced neurotoxicity through neurotrophin TrkB signaling [PMC8806570]. In summary, BDNF-AS is an antisense RNA that negatively regulates the expression of BDNF. It plays a role in various biological processes and has been implicated in neurotoxicity and cognitive functions. Further research is needed to fully understand its mechanisms and functions.

Genome locations

Gene Ontology annotations

Sequence

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AUCGCGAGAUCAGGAAGGUGGCCGAGUGUGUCGCCGCGGCCAUCAGGCACUUCUCCUUCCUGCCCUUGUAUGAAGAAGGAUGUGUUUGCUUCCCCUUGUGCCAUGAUUGUAAAUUUCCUGAGGCCUCCUCAGCCCUGCAGAACUGGGGUUAUAGCCAUGUGACUGAUCUUCGUCCAAGAAUAUGUAAAGAAAAAGUGUUGAGUUGGCUUUUAGGGCUAGAGCAAUGUAUCUUAGGCUCACUUAAGGAAGCUGUAGAGAUGAGCCCAAGGAGGGAAACCAGAAGAGCCCCCCAGGCUCACCAGUUGUUUGUUGGCUCCCUACAAACAUGUCAUUCAAGUGGCUAAUCUUACAACAGCACAAAUUCAUCUAACCAGAAAGAGAAGAGGAGGCUCCAAAGGCACUUGACUACUGAGCAUCACCCUGGACGUGUACAAGUCUGCGUCCUUAUUGUUUUCUUCAUUGGGCCGAACUUUCUGGUCCUCAUCCAACAGCUCUUCUAUCACGUGUUCGAAAGUGUCAGCCAAUGAUGUCAAGCCUCUUGAACCUGCCUUGGGCCCAUUCACGCUCUCCAGAGUCCCAUGGGUCCGCACACCUGGAGAUACUCUAUUAUAGCAAAGAAGAAAGAUAAUUUCAUUGAGCCAUCCUGUUUUACAGUAUUGAAUUAUUACCACAAGGUACCAACCAUAUAUGCAUACUUAAUAGGGUAUUUUGUCAAAACUAUGCAUGAAGGUCAUUUGUUUGAGAUGUCAGAACAUUUUCCCGUGAGAAGAUCUCAUUGGGCAUUGAAACAGAACCACAUGCUCUUCAGACCAGCAACCGCGACUACCAAAUACUCCUCUGUCAACUCUACUUGAGUAAGAACGCUUUCAAUUAAGGCCUAAGUGUCAACAUGCCUUUAAAAAAAAUCGUGGUGACACAAAAUCUUUCUUUUUAGCACCCAACAGAAUCCCUUCAAAGCCUCGUGGUCUGACACCCUAUGCUACGUGACUUGUGACCCAUCCAUUUGUCAUGUUCUUCGGGAAUGUGGCUAAGGGGCUAAGAUGUGACUUGAAAAGAAAGGUAGAACAAGAUCAUCUCAAAUUUAUUAUCAAGGAAUAGUUCAGAAAACGACUUCAGACCACAGAGACAGCAGAACAGAUGGUCCGGCAUGGAUAGAGCAUCAGACACUCACAGACUGUGCCAACAAGAGCCAUCGAGUCAAAACAGCCAAAGGAAGGAGGGUCAUGGAAUGGGUUCUCUCACACCAAACUGAUGCCCAGAGGCCCUCAGCAUGAAUAACAAAGGCAACCAGACCCACAAGCCAUACUGAGUGGAUACAAAACCUAUACCUAGGCUGACAUCCCAAAUGUGUGUGGCAAGUUAGAUGAUGAUGGCACAAAAGACAGAACACCUUGCUUCUGGCCAUUGUCAGCUCUUGGAAGAGAGCACACUUUUAGAGGAGCAGCUGCAAGGAGCCUGAGAACAAAACUGGAAAUGUCUGUUAUGAAAGCCUUCACAGGAAAUUCUGCAAGUGGCAACGUGGGUCCAUUCCGUGUGUGUCACUAGAGCUGGCGCAAGCCCAUGGCCAUGGUGAGGCAGCGUUUCCACUGGAACUAAUCUGAUACCUGCACCAGCUCUUGCAACUGUGCAGUGUUCCCACUGCAAACUACGGAUGGGGUAAAAGACUGCUCACCUCCUAUUUCUCAUCUAAUCUCACACACUCUGUUUGAUGAGGCUAUGGAGAAACAGGUCUUCUCAUACACUAAAGGUGGGAGUACAAACAAUUCAAGCCCUGUGCAGGACAAUUAGGCAAUACCUAUCAAAAUUAUACAUGAUUUUUCCUGCUGACCCAGCAAUUCCACUUCUGGGAAUAAUUGACAGAUAUAGGUGCAUAUGUACAAAAUGAUGGAAAGCUCUCUGGUAUAUAUUAGUAAGUGAUAAAACAAGGUGUAAAAUAGUGUAUAUAUGGCUACUACCUUUUGUUUUAAAAAUGGGGGAAAAUGGUGGAGCUUGCGGUGAGCCGAGAUCGUGCCACUGCACUCCAGCCUGGGCGACAGAGCGAGACUCCGUCUCAAAAAAAAAACAGGGUGGGGUGGGGGGGAAAUAAUAGUACAUACUCAUAUUUACCUGUAUCUAUAUAAAACACACUAUCAAGGAUUCACAAGAAACUAAUACAAAUGAUCACCUUAUAGAUGGUAUGUAUUGGGGGAUACUGAGGUGAGCAGGGUAUAAGUGGGGCAAGACUUUUCAGUGUAAACUUCUUUUAAAUUUUAUUUUGAUUUUUGAAUAAUGUAAAUUAACUGUCAAAUAAUUAAAUUAAAAAUAACCAAUUUAUUAACAAAA

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Publications