v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) RUNX1 intronic transcript 1 (RUNX1-IT1) URS000075E3D1_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

RUNX1-IT1: RUNX1-IT1, a long non-coding RNA (lncRNA), is involved in the maintenance and invasion of lung cancer stem cells (CSCs) [PMC8799095]. It does not affect the promoter activity of GPX4, but its knockdown leads to a shortened half-life of GPX4 mRNA [PMC10086083]. The binding of miR-21 to the fusion RNA reduces the translation of Luc (+), resulting in decreased luciferase signal [PMC10086083]. RUNX1-IT1 is transcribed from the intron of the RUNX1 gene, an important transcription factor in tumor development [PMC7265432]. CatRAPID analysis suggests that the 1111 bp-1173 bp region of RUNX1-IT1 is likely bound by RUNX1 [PMC7265432]. Low expression of RUNX1-IT1 in liver cancer patients indicates a poor prognosis and it may serve as a biomarker and therapeutic target for liver cancer prognosis [PMC8799095]. Furthermore, rescue experiments demonstrate that RUNX1-IT1 upregulates C-FOS expression via RUNX1 [PMC7265432]. Overexpression of RUNX1-IT significantly inhibits hepatocellular carcinoma (HCC) tumor growth compared to control groups [PMC7002583]. These findings collectively suggest that downregulation of RUNX1-IT may lead to increased tumor aggressiveness [PMC7002583].

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
UUUAAACUGCUAGAAAGGAAGAGCCGAAUAUUUGGCUGGAGUGAUUUUUAGACAUUUCUCUACCUUAGGGCACCAGAGAGGUUCACUUGCCCAGGGUUCCAUAGCUGGUUGGUGCCAGAGUCCGAACGAGAAACCAGGUCUUCUCAGCUCCUGUCACCCACAGUUUUGCAGACACUGAAUUUAUGAGGUGGAUUCCAUUCAAGCAUGCACAUAACUAGCAGACACUUCUCCUAAUCCUCCUCAAUUCCCCUUUGCAUUGCUCAGAUACCACAAUCCUUUGCAGGUUAAAUCCCUUCACCUUGUGAACUCAUUAGGCAGGGCAAUGUAUAUGAAUCCCUGAGUCCUUAAGAACGUCCUUAGGCUGUGUUAGAAAUGCAGUUGCCAUAGGAGUAACCGGCCCCUGCUGUCAUUUGGAUGUUCUCUCUUCCCCAAAAUCCAGCACCACCUUGGUUAAGCACCCACCAUGUGCCUGCCCACCUGGCUCCUUAGGCAAUGUUACAAUUAACCAGGUUGGUUUUGAUGAGGGUCUAGGGCAAAAUUUGAACCACCACAACAGCCAAUGUGCACAUCCAUGCAGAGGGUUCAGAGAUGGCCUCGGCCAAGGCUGCCAGGCUUCAGCUCUGGAAGGAGCCCUGGGAAGUGGGAGAUCUUUGUAUAAAAAUUGGAACCCAAACUAUAAUUCCCAUUAGGGAUAUAUAUGCUCACAUCACUCCUGAUUCAAAGCUCAGAAGUGGCCUCUCAGGAGAAAUAAAGGUCUCUCUCUCUCUCUCUCUCUAUCUCACACACACACACACACACACACACACACACACAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGGCCAGCAUUCAAAAUUCCCAUGCUUAGGGAAUCCAUUGGGACUUCUCCCCAGGAUGUACUGAAUUCAAGGAAGCUUUCUCUAGGUGUAGCAGAAACUGCUGCUGUCAUGUCUCUGCUCACCAGGACGUAGCUUCUCUCUACAGACCUUUAUUUCUUUCCCUGGAGGCUUCAGUCCAUGUUGAAGUGUAAACUCCACUCAGCUCCAGGAGGAAUCGUGUUUUCUUUAUCACCAGGGGCUUCUUCUACGAGUUGCCUUUGAUAGGGAGGCCAGGAGGAAGAUAGGCCCAAGCUCAGGGGUGGGAUCGGGGAGCAGGAAGCCUGUGGGCUUUAGAAUCGAGGUAUUGGUUUCUCCCUGUCACCAUCAUCCACCACCUGUGUGAACUUGAGCCAUUUAUCGAACCUCACGGAGCCCCAAGUUUCUCAUCUGUAAACAAGGGGAAUGAGCCCUACUUUGUAUGGUUGUCAAGAGGAUUUGAGACAAUAUGUAUAAAGCAAUGGACACGCAGAGGAAGUCAAUAAGUACAAGGUAACUCUGAAAAUGCCACCAAAGGGAGGCUAGGGACAGGAAAGCCAUCUCCGCCAACCUCAAGAACGUGGCCCCGAAGCUGUUCCAGGAACUGGGCAUGUAUGAAGAUAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications