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Homo sapiens (human) SND1 intronic transcript 1 (SND1-IT1) URS000075E1A9_9606

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SND1-IT1: SND1-IT1 is a type of long non-coding RNA (lncRNA) that has been found to play a role in promoting cell migration and invasion [PMC9229915]. The overexpression of SND1-IT1 was shown to enhance cell migration and invasion, but this effect was completely reversed when USP3, a protein involved in cell migration and invasion, was interfered with [PMC9229915]. The researchers also investigated the mechanism by which SND1-IT1 exerts its function by sponging miR-132-3p/SMAD2 axis [PMC8806201]. In experiments where SND1-IT1 was silenced, the suppression of proliferation, migration, and invasion in WERI-RB1 and SO-RB50 cells was significantly attenuated when miR-132-3p was depleted [PMC8806201]. These findings suggest that SND1-IT1 promotes cell migration and invasion through its interaction with USP3 and the miR-132-3p/SMAD2 axis [PMC9229915][PMC8806201]. Understanding the role of SND1-IT1 in these processes may provide insights into potential therapeutic targets for diseases characterized by abnormal cell migration and invasion.

Genome locations

Gene Ontology annotations

Sequence

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GUUUGAUUUUUGUGGGCCUUACUUUUCCCAUUUGCUCAUGUAUGUCUAUAUUCCUAUAUCUAAUGUUUCUUAAAAGACAAAUCUGACUGUGUAGGUGCAUUUGUUUAAAAAAUAUAACUCCCCAUUGCCUCUGGGAUAAAGUCUUAUCUCAGUUUACAUAUAUUCUUGAUAACCUCUCCAACUUUAUGUCUCACCACCCCCACUCACUUCGUAAUUCGUGCCUUAUCAGAAUGGACCUGUUAUACUGGCAGUUCACCAUAUAUACCAUUACAUUUUGUUUCUCCCAUCUCUCAGGUAGACUUACACUUUCGGCCCAGCACAUCAGUCAUCGCCCUUGCUUGCUUUCCUAUUCACUCCUGUUCUGGAAGGUGCACCACCUUUUCUUGGAAGGCUUCCCUUGCUCUCCCAGGCUAGAUGAGAUGUCCUUCCAUCAGUUCCCACAGCACCCUGUGCAUGUAUCUGUUGUGCACUUACCAAUAGUAUACAAGGGAUCUAUGACCCAAGUCUCUCCCCACUAGCUUGUAAGCUCCUCACAGACAGGAACCAUGUUUUGUCUUUGUACUCCAGUGCCUAGUAUAUAAGAGAUACUCAAUAAAUAAAUAUUUGUCAAAUCAACUAAUUGAUUCCUUGUGACCUAAUUCUAGAGAAUGGGAAGAAGGCCUGUUAUUUUGUUGUCCUUUAUGGUUCUUUAGGAAAGCUCUCCAAGCUUGGCAUUUGUCAGGGUGGGAGGAAAACUGUUGAAGUAUUAAGACUGGACACAUGGCUGCUAAUUCAUCAGCUUAUCAUUGAAAAAGUCCAUAGCCAAAACCUGACUGUGCACUUACUAUAGGACCCUGACCUGCCUGGGUCUCCCUGUCUCUCCAGCCAGUAUAUUUAAAGGUAAUGAGAUAAUGAUGAGUGUUUUGAAAAAUGUUUAGUGUUCAAAUAGAAACCAUUCGUGUCCCUUCACUCUCUGAACAUAGUCUGCAAAUCUCUCCCUCUCUGGUAUGUUUCUGUUUUGUGGAUUAGACUGCUAAAUAAGCGAAGAGUUAAUUUUGAAGUUCAGGUCAACAAAUUCCUGUUUGGAGACGGGCUGUUCCUGAAUACCAGGUUGUUAUCUGUCUAUUACAGCCCCUUCACUUCUGGGCUCCUGGCCCUUUGCGAAGUACUUCAGAAAGCCUAGAGAGAAGAGAGGGCCCUCAAAUCCCAUUCCAGCCCCUAAAUGAAAGUGGCAUCACAAGGAGAAAAGUGGAGGUAGAAAUGUACCAUGGGGGACGUUGCCCCAUUGCCUUUCUUCCCCUGACUACUGGGCUUCCUCUAUCAGCUUUUAACGCCUGGAAGUAGCUGAGUCUCCAGUCACUGGUGGCCUUCCCCAAGUGAGCUCAGCAGCAUGUGCUAAUAGGUGCCAAUACUGUGCUGGCUCCAGUGGGAUUCCUCUCUGCAAAGCUGCUGGCUUAGCUUGACUGUUUCCCUAUUCCUCUCCUUAGAACUUUCAUAGCCAGUCAAGCAUAGAAUUGCAUCCAUUCUUCUGAAAUAGGUACUGUGCCUAAUUUUUCAUUGGCUUGGCCAAGAUUCUGUUACCUGUAAUUAUGUCAUAUGGGCUGACUGGUGUAGGUUUGGUAGGCCUCACUGCUCUCCAGAGGCUAGUGUUCCUAUCCCAGGAUGGCUGUUGGGAUUAGGAGUGGAAUGAGGAAUAGUUUAGGACCACAAGAGAUUUGGCCUCCUUGGAACAUGUAGGAAGGCCUCAAGGAUGUAAUUCUAGCCCAGGGAAGAAAAUCCUUUUCAGCAGACGCUUCCCUUCCCUUCCCCUAGGGAAUGUGUCCCUACUAUAGUAAACUCUUCCUUAAGAGAGUUUUAUGUUUUCUCUGUCAGAUCAAUUUGUUUUUCUUAAUGUUGUUCCUAUCAAAAAAAAAAAAAAGGAAGAAAUACAGUCCUCAGACCUGACAGUUUCAUUUUUCCCCCCAAGUAGAAGCAAUAGAAACCUUAGCAGUUCCAAGACUCCUGGCACUCACUUUUCCUCUCCAUCUUUAGGUCUAACCCAGCUCAGCCCAGAGUAAAGACAUAAAAGCCUCACAUGUGAUUUCCUCUUGCAUUUUUUCUGCUAGAAGGGUCCACAGUACUUACUUUAUGCCUCAUCUCAAUUGAAGCUGGAUGAUGAGGAUAGUGGGCAGUGAUUGCAAUUGGGGAAUGCAUGUACUGGAUCACAUAAGGUCAUGAAAGUCCUUGAAACAGAGCCUUGCCAAGCAGAACCCUUGCCACUCAUGGUAUUCGAUACAGUCUACCCAUCUGACAUGAAAUGAUAUUCUUAAUGAGCCAUUCCUAUGGAAGAUAGCUAUUGCCAGGCACAUUCAGUCUCCUGGUCUCCCUCUCAUAGCUAUGUAGGGCCUAUGACCUAGAAUAAAUGGAAAAAUGUUAUCAGGAGGAAGAGACUGCUGGACUCCCCUGAGAGGUAGGGUUUGUGCUAGGAGAGCUGGGUGCCAUUUAUUUCAUUUUGAUAUAUCAGGUGCUCCUAGUAACAAUUCCUAGUUUCUCUUACCUCUGUAAUCAUCCUGAAUAGUCACUGCUUCUUGAGCUUUGGUGAGUGUUCUCU

Taxonomic tree

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Publications