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Homo sapiens (human) long intergenic non-protein coding RNA 689 (LINC00689) URS000075E164_9606

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LINC00689: LINC00689 is a long non-coding RNA (lncRNA) that functions as a competing endogenous RNA (ceRNA) by sequestering specific microRNAs (miRNAs) and indirectly influencing mRNA expression in cells [18] [PMC8021259]. In gastric cancer (GC) cells, several lncRNAs, including PTCSC3, MALAT1, AC118344.1, LINC00689, and p4516, have been identified to function through this mechanism [19–23]. MAGI1‐IT1 is another lncRNA that acts as a ceRNA by binding to miR-302d-3p and suppressing cervical squamous cell carcinoma tumor growth [13] [PMC8021259]. The ability of MAGI1‐IT1 to sequester miR-302d-3p has been confirmed through luciferase reporter and RIP assays [PMC8021259]. LINC00689 expression has been found to be elevated in various gastric cancer cell lines compared to normal gastric epithelium cells [PMC7280092]. Additionally, patients with advanced stage prostate cancer (PCa) have shown higher levels of LINC00689 expression compared to patients at an early stage [PMC7275594]. Overexpression of LINC00689 has been found to inhibit apoptosis in non-small cell lung cancer cells through the activation of ATG7-dependent canonical autophagy [PMC9684738]. In a study on hepatocellular carcinoma subtypes, LINC00689 was identified as part of the first module in subtype 1 along with other lncRNAs and mRNAs [PMC5349869].

Genome locations

Gene Ontology annotations

Sequence

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AUGAGAUGUUAGUUGGUACAGGGAGGGGUUUCCAGGACCCGCACGCCCUUGCGGAGUGCCUGCUGGAGGGAGCCGGUGUGUCCAGGACACCCUUGCGGAGUGUCUGCUGGAGGGAGCCAGUGUGUCAGUGAGAUGGCUAUGCCCCUGGGCUGCUGUGUCCCAGGUUUCCUCAGUCUCUAACCCUUUGUUCUCACAGGGGAUGGACUCUUGCUUCUUUUCCCAACUCCACCAAGAGGGACCGUCCCAGGACGUCCUUCCCCGGGCAUCUGGCCCUACAGCUGCCUGAGGUCUCCAUCACCGUUGGCGCCAUCAGUCUGCUGUGCAGCCAGCUGUUGGUUUGGAGAGCCUGAAGAACUGCAGUUCACGUCUCAUCUAAAGGAGCUGAAAUGAUAUUGCAGCUUUUUCUUUUGGUUGCGUGCAGUGAGAAUCUGGGAGCUGAACCUGUUAUCUGCAUGGUCUUCAGAAAUCAGGCAAACUCGGAAAAUGCCAACGCCAAAAAUGCUGAUGGGUGACAAAGUGUCACAGGUGUGAUGCAUUACAAAUCUCAGGACUUUUGUUCACUGGAUUUGAAAGGUCAAGCUUCACAGGAAAAUGAUGAAGUCCCAAAAGACCAGAAAUAUAUUUCAGAAGAUGCCAGUUACUACUUUAAAUGUCAAACCAACAUUUCAGAAAUAACUUUCAAUGAUUAUUUCCUGCCAAGAAGGUGAACGCUGGAGACCUUAAUGGUGGAAGAUGGAGGGCGUCUUUCCUUCUGUUAAGCUGACAACUUGGCUUCCAUCUUGUGAGGACCUCACCCUACCUGGUGGCAGAGGACGUCUGACGCCCUCAAUCAUUGCCGUUACACUUCCCAGCCUGGUGGUCAGUCUCCUGGGGUCUGUGUGUUAACAAACCAUCGACUGGACAAUCGCAGUUUUCCUUAUGAAGGCUUACUUUAAAAAGGCUCUGGAUUUUCAGAAGCGAAGUCGCUUUCAUCCCCGAUUCAGACCCAUCCUAGUGGAGGAAAAAUCCUACCAGAAGAAGGGCUGACCAUAGGAACUUGCCAUUUCCUUGACCCCAUCAUAUCUGAGGAAAAAACAACAGAAAAGGUCAAAACCCACGUGUACGCCCAACGUCCUGAUUGACGACUUUGCCUGCAGCUUCUGCUUUCCUGAAAUUCGCUGCUGCCUUUAGAACCCUUGUCUGCAGCCAGUGGGGAGUUCAGGACUUAGGCGGAGCUGCCCCACCCUCCUGCUUGGCACCCUGCAAAUACAUGCCCUCCCUUCCAUCGCUGCAGACCUCAGAGUGGGCGUCCGGUCUCCUGUGCGGGAUGAGAAUACACACCCUCCCUUCCAUCGCUGCAGACCUUAGAGUGGAUGUCCGGUCUCCUGUAUGGGAUGAGAAUACACGCCUUCCCUUCCAUCGCUGCAGAGUGGACGUCUGGUCUCCUGUGUGGGAUAAUACACGCCCUCCUUUCAAUCGCUGCAGACCUCAGAGUGGACGUCCGGUCUCCUGUGUGGGAUAAUACACGCCCUCCUUUCAAUCGCUGCGGACCUCAGAGUGGAUGUCCGGUCUCCUGUAUGGGAUGAGAUACACUCCUUCCCUUCCACUGCUGCAGACCUCAGAGUGGACGUCCGGUCUCCUGUGUGGGAUGAGAUACACUCCUUCCCUUCCACUGCUGCAGACCUCAGAGUGGACGUCCGGUCUCCUUUGUGGGAUGAGAAUACACUCCUUCCCUUCCAUCACUGCAGACCUCAGAGUGGACGUCCGGUCUCCUGUGCGGGACAAGAAUACACUCCUUCCCUUCCAUCACUGCAGACCUCAGAGUGGACGUCCAGUCUCCUGUGCGGGAUGAGAUACACUCCUUCCCUUCCAUCGCUGCAGACCUCAGAGUGGACGUCCAGUCUCUCUGUGCGGGCCAAGUGUACACAGUUUUGUUCCGUCACAACUUCCACGACAGGCCAGUGUGAGGUUUUUGAGCUGGUGCUGACUGAAAACUGUCAGCUGCCCAAGGACCUGGGAGCUCUGCUCCCCACUCCUGGUGUGCGGUCUUGCGCCUGGCCUCCCUGCCUAGGUUACAUGCAGUGGUCAUCCCGGUCGCUCCCACACCCGUGUGGGCUCUGGGAUCCCCUCUUCCAGCCAGCCCAGGGGACAUCUGGCUGUCUCAGGACCCAGCCAUCUGUAAAAAUUAGGCAGGUCCCUUCAGUAUGCUCCUGGUCAACAAAGAAAAACUUCAAUUUUGAGAAUGGCAUCUGUAUUCCGAAGUGUUCUCUCAGAUGUUUGAGUUCCACUAAGUAGAUUUUCUUAGUCUGCUGUAUCAAUGACACAGAGAGACGUGCAUUAAAACCUCAACCAUGUGGAUCUAUUUCUUUUCAGUUAAUUUUGCUUCAUGUAUCUUGAAGCUCUGUUAUCAGGUGCAUGCACAUUUGGGAUUGUUAUGCUUUCCUGAUGAACUGACCUUCUUUCAUUAUGCAAGGGGAAGAAGAUGCUGCAUACAGGAUGGAAUAUCCAGGGGAAGACGUCUAAGGAGAGAUGCCCAGCUGGGAGUCCUAUGCAAGGGGAAGAAGAUGCUGCAUACAGGAUGGGAUAUCCAGGGGAAGAUUUCUAAGAAGAGAUGCCCAGCUGGGAGUCCUAUGCAAGGGGAAGAAGAUGCUGCAUACAGGAUGGGAUAUCCAGGGGAAGAUUUCUAAGGAGAGACACCCGGCUGGAAGUCAAGAUAUGUCAGUUGUUUCCAUUAUAAUAAAACCACUCAUGUUAGAUGAGCUGAACUUUCCCUUUUCCCCAGUUCUUACGAUCAAAAAGUGGCUGUCCUAAAUUUCAUCACUCAAUAUCCUUGCUAGAGUCUUCCUUUGUCAGCCAGGCUGGAGUGCAAUGUGCAAUGGCACAAUCUUGGCUCACUGCAACCUCUGUCUCCUGGGCUCAAGCAAUUCUUCUGCCUCAGCCUCCUGAGUAGCUGGGAUUACAGGGCGCUGGGUGCCCUUCCAGGGUGACCUCACGGGUGCCCACUGCAGUUCCUGCUUCUCCCCACGGGAACUGAGCGUGCCGCUGGGAACACAGCACUCACUGUGCACAGUUCUGCACAUGGACUUAUGUGGACACCACCUGCUUGCAUUCAUCCCCUCCUCCUCAUCUCUCCCUUGCUGAGAGGCAGCGUGCCUGCCGAACGCUUCGUGCUGUUUCUGCAAUGCUCACUUGCGGUCACAUAGUUAGACAUCCGGAUGAUGGAUAGAUGAGGAGACACAGUGCAGACUGGGCGUGGCUGACCACCACACGUGCCCCUGGAGCCAUGGGCCGCCGGCUUCAUUUCCAGGGUGGUGUUACAAUCAAAAGAAUGAACACAUCAAGAGUGAUUUCAAGUCCAACCCCUUCCCUGUGUUUUCUGCACAGCUUGGAGGCCGUGCCCAGGUCCUGGAUGUUCCUGGUGACCUUUCCUCUUUGCCCUUUGCUCUCCCACUUGGAGCUCCAUGCUACUCCCUCCUGUUGUACUGAACCUGGCCCUCGUUGCCCCUUACGAGGGAAGUCCUUGUCCUCUCAUGGCUUCCUUCUUGUCCCCUUCCCUCAGACUCUUCGUAAUAAUUAUACAAUACUAAUUCCAAAUGGAAACUGGAGGCAUGGAGCCUAUGCCGGCGUCUCCAGCUUCUCCAGAGGUAGGAAUGGACACUCAGGUCUCCACUGCAUGCUGGUGGAUUUGGGAGAGUGUGAUCCAUCCAAGCCAUGCGAAAAUCUGCACGACUGAGUCAUGGGACAGUGGAGCUUUGUGAUAUCGCGUGCUUUUAAAUCCGAAAGGACAGUCAUGAUUUAAGGAUUUGAAAGUCACACAUUUAACAUCUGGAUUCACAGUCAUAGGUCUUAAACCAUGAUAGCUUGUGCUUCUGAGGUGCACUGAAUUCAUGCGUGGCUUUCCUAGACUUUAUCCCAUGGAACCUUCACGUGUCAGGCUAUGUAGAGCCCUGAAUCUCAAAGGGAGAGCUUGGUCCCAGCAGGUCUCAUUAUUUUGUAUUAUAUUUUAAUAGUUUAUUUUCCCUCUUGCUUCUUCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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