LINC00278: LINC00278 is a long intergenic non-protein coding RNA (lncRNA) that is involved in various biological processes and diseases [PMC8649637]. It has been found that smoking increases the expression of ALKBH5 and reduces the m6A modification of LINC00278, leading to the inhibition of YY1BM translation and the progression of esophageal squamous cell carcinoma (ESCC) [PMC8649637]. Sex differences have also been observed in the expression of Ps4y1 and LINC00278, suggesting a potential role in ESCC incidence disparities between men and women [PMC8773626]. The m6A modification of LINC00278 has been proposed to regulate YY1BM translation, contributing to the higher incidence of ESCC in men compared to women [PMC8272376]. LINC00278 is normally expressed in whole blood, and its upregulation may serve as a defense mechanism against viral replication [PMC8518135]. It is closely associated with other lncRNAs such as XIST and LINC00402, which are involved in interactions with specific miRNAs associated with CD44, ADGRG1, RASSF4, TGIF1, KCNJ15, and BCL2A1 [PMC10110604]. YTHDF1 has been found to restrain ESCC by interacting with LINC00278. Conversely, ALKBH5 exhibits an opposite function [PMC7412851]. The translation efficiency of Yin Yang 1-binding micropeptide (YY1BM), encoded by LINC00278, is enhanced when m6A modification is demethylated by ALKBH5. This enhanced translation protects esophageal squamous carcinoma cells from apoptosis induced by nutrient deprivation [PMC9617417]. Overall, these findings highlight the diverse roles played by LINC00278 in various biological processes and diseases such as ESCC. Further research is needed to fully understand its mechanisms of action.