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Homo sapiens (human) HIF1A stabilizing long noncoding RNA (HISLA) URS000075DEBF_9606

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HISLA: HISLA, a type of protein, has been the focus of research in various studies [PMC8990175]. In a trans-ancestral meta-analysis, 36 signals in established loci in HISLA were discovered [PMC8990175]. Additionally, it was found that HISLA promotes the stabilization of HIF-1α by directly binding to PHD2 and forming a stem-loop structure [PMC7549355]. Furthermore, it was observed that TAM releases HISLA into exosomes in the microenvironment [PMC7940039]. These exosomes enhance glycolysis in recipient cancer cells and provide protection against chemotherapy-induced apoptosis [PMC7940039]. These findings highlight the significance of HISLA in various biological processes and its potential implications for cancer treatment [PMC8990175][PMC7549355][PMC7940039].

Genome locations

Gene Ontology annotations

Sequence

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GUUAAACAAGUGCUUGAAGGCAGUAUGCUUGGUAAAAGUCAUCGCCAUUCUCUAAUCUUGAGUACCCAGGGACACGAUACACUGCGGAAGGCUGCAGGGACCUCUGCCCAGGAAAGCCAGGCUUGCAUGAAGGAAAUGAUUUCCUAUGAUUCUGCUUACUGCUUAAAAAAAUUAAUCAAGUUUUCUGCCUGACAAGAUCCAGUAUCUGCCGGAGGAGCCCCACCUUCUGCUACUAUUAUGUUCUUCAGAUGAGUAGAAGAGAGUGGGGAGGGAGAGAGCAGGAAGAAGAAAGGAAGAAUAAUGUCUUGAAAUUGUUUUCUAAGGAUAAUGGUCUCCAGCUUCGUCAAUGUUCCUGCAAAGGACAUGAUGCUGACUUUGAAGAUGCAAGCUUCCACAUCUACAGCCUCAAGGAAACAAAUUCAGCCAACCAACUGAGGGAGCUUUCCUUGUCCUGCCUCAAGAUGAGAUCACAGUCUGCCCAACACCAUGAUUUAGGCCUUGUGACACCUGGUAUGGAAGACCCAGUUAAGUUCUCUCCAAACUCUUGACCCACAGAACCUGUGAGAAAAUAUAUGGAUAUUAUUUUAAACUGCUAAAUUUGUAGUAAUUUGUUAUGCAGCAAUAAAAAAAACUAAUGCAAGGAGAUAUCAAUUAUUGUAAAAAGCUUAGCUUUUGUUUUAAAAUAUAGUUCACCAGUAGUAAGUUACUAAUAAGUAACUAAACAAAUAAAAGCAAGCCAUUUACAAAUCAAUAAUAAGAGUAAGUCAUGAACUAAAGAUUGUAAUUAAUCAAUUUCUGUACGCCUGUAAUGAAAAUAAAGGAGGAAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications