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Homo sapiens (human) cholesterol induced regulator of metabolism RNA (CHROMR) URS000075DD89_9606

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CHROMR: CHROMR is a long non-coding RNA (lncRNA) that localizes to both the nucleus and cytoplasm of macrophages, as revealed by cell fractionation studies [PMC9477407]. In the context of TCGA LGG patients, high expression of CHROMR was associated with a significantly higher hazard ratio (HR = 1.7, p = 0.0033) [PMC10025505]. This suggests that CHROMR expression alone is a potential risk factor for these patients. Additionally, it has been found that increasing the expression of miR-1299 can counteract the rituximab resistance caused by high CHROMR expression [PMC9189216]. This finding suggests that miR-1299 may have therapeutic potential in overcoming resistance to rituximab in patients with high CHROMR expression. Overall, these studies highlight the importance of understanding the role and localization of CHROMR in different cellular compartments and its potential implications for disease prognosis and treatment response in specific patient populations.

Genome locations

Gene Ontology annotations

Sequence

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CUCCGCGCCGCCGUCUUCGUUGCUCUUGGGUGGCCGCGGCGCCCGCUCCCUCUGAAUUCGCCGGGCAGGGAUACAGCCGCCCGGGGCCUCUUGCUCGUGCUUGGUUUUCCGGACCUUGCUUCCUAAAGGGUCUUUAGGGGUUCCCGGACUCCUCCGCCUGGGAGCCUCUAUCCGCCUGGGAGCCUCUAUGCGCCCCGCAAAGCCCCCGGCAGAGCCGAGGGGAGGCUUCAUUGGCGACCUGGUGGGGCCUCGCGGCCCUGCUCCCUGACGUCAGCGCCGCCGCGGUGAUUUAACAGCUUUUGUUUUGGGCAGAAGAACCUAUGGGCACAAAAAGCAGGAACGAGUAGCGGUGGCUGAAGAACGAGCAGGAGCUUGAAUUUCAGUUUUCUUAUGAGGAAUUUUCCAGAAAAGAUAUCUUCACUGUGAAAUAACUAAAUAAAUGCCCACUCAGUACAGUCACUGUCUCCCUUUUGGAACUUGAUGGCACCUUAAGCCCAGGUUUGCCUCCACUCUAGAAACUCAUCAGAGUGAUGCCCUUCUCAAAUGGGGGAGGUCCCAAAGCGGAUAUCCUGGCAGUGUGAAAGGCCGGCUAAAGGUUUGUGCCAAGAGGAUCUGUGGAAUGCAUCUCCUACAGCUGGUGCUGCUGAGUAACCACUCUGAUCUGGCAUCUUCUUUGAUCAAGUUACAGAGCAGAGUUUCCAGGGCUGGGGAUUGAAGUCCUGCCUCCUCCCUUUGUCUCUGGUUGUCCUCGCUUUCCCUGCACUCCAAACACAGAGCUGAGACUUCCACCUAAUGUAGAAAGCUAGCACGAGCCGGCGCUGACAGAUGGAAGACUUGAGAUGUUACAAGAUUAUAUAUGGAAACACAAAAGGAGUGGAGUUGCUGGGUCAUAUGGCAAUUCAUUUGAGGAACUGAGAAGCUUAUUCCAUGGAGGCUGAACUGUUUUAUAUUCCCACCAGCAACGUUAGAGACGGGGUUUCACCGCGUUAGCCAGAAUGGUUUCUAUCUCCUGACCUCAUGAUCCGCCCACCUCGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGCCACUGUGCCUGGCCAAACGCUGGUAGGUUUUGAGUGAGACCACAUUACAUUUAAAUAUAUUUACAAUGUUUUCUGCUCUAUUCUUUAGUAGACUUUUCCUCACGUGGUCCUACGCAUUUCUUUCUAAGUUUAUUUUCAUAUAGCCUAUCCCUGUCUACAAUUUAAAUUGGGAUCUUCUAUAUUCUAGUUAUUAUUUGUAAAUAAGAAAACUACUGACUUUUUUCUAGUAUAUUUUCUCAGAAUAGGAUUUUCUAUUUUUCUAUAAAAUGACCAAUGUUAUGAAGCUUCGUAAGUUUUGUCAAAGUGAUACACACAUACAGCAAAAAAUCAAAUAGUACAGAAGUAUAAAAGCAACAACCUCUGCCUUGCCCCUUCUCCACCUUCAGGUCCCCUUCCCAGAUACAAUAAUUUUUAGCUUUUUAUUUUUAAUUAUUCUGGUUGUUACCUACAUAACUCUGGGCAAUAUGGAAAAGUUAUUGAUUUUGUAUAUUAAUUUCAUAAUCAGUUACCUUGAUGAAUUCUCUUGUUUCUAGUAGUUUUUCUUUAGGGUUUUAAAGGGAUACAAUCAUACCAUUUGCAGUUAGUAACCAUUUUAUCUCCUCUUAUUUCCAACUUCGUACUGUUUUCUCUUGUCUAAUUUGUUUUUAAUUGGUGGGUACUUCUAGAACAAGGUUAAAUAAAAGUGGUGUUGGUGGGCGUCCUUAUUUCUGAUAUUAAUGGGAAUGAGUAUAAUGUAUAAAUAUAUAACCAUGAUUUUGGUUUUUUUCCAAGUUUUUAUCAGUAAUGAUUGCUGAGUUUUAUCAAAAUUUUUUUGGCAUCCAUUGAGAGGAUUAUAUAUUACUCUUUGACACAUUAAUGUGGUUAAUUAAAGUAACCAACUUAUUAACCUUGAAAUAGUCUUAGUUAAAUAAACCCUACUUGUCAAUGCUAUAUCAUUAUUUUAAUAUUGUACUGAACAUUUUACAAAGGUGUUUCACCAUAAGGCAUAUUGAUCUGUAAUUUUUUUUUUUCUGUUGAACUUGCUAUUGUCAGGUUUUGGUGUAUUAUGUUGGUUUUGGAGAAUAAAUUUAAAAGUUUCCUUUAUGUUAUCUAUACAUUGCCUGAAAAGAGUUUAAAUAGCAUUGAAAAUGAUCUCUUCUUUGAAGAUUUAACCAAUUUCACCUGUAAAUCUGUCUGUGCUUUGUAAUUUUGGUGAUACUGUUGACUCAAAUUCCAAAAGCAGUAAAUGCAGUGUUUUAUAUUUUUCUAUUAAAAAUGUAAAAUCAAAUUAUAUUAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications