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Homo sapiens (human) MAPT antisense RNA 1 (MAPT-AS1) URS000075DB76_9606

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MAPT-AS1: MAPT-AS1 is a long non-coding RNA (lncRNA) that has been found to be associated with various aspects of breast cancer. It has been suggested that MAPT-AS1 may play a role in the sensitivity of breast cancer cells to the chemotherapy drug paclitaxel [PMC5799917]. Studies have shown that MAPT-AS1 is a low-risk lncRNA with a protective effect on clinical prognosis [PMC9478756]. Additionally, the expression of MAPT-AS1 has been found to be inversely correlated with Tau pathology, decreasing as the disease progresses [PMC8774680]. Knockdown of MAPT-AS1 has been shown to inhibit the migration and proliferation of ER-negative breast cancer cells [PMC9389369]. Overexpression of MAPT-AS1 has also been associated with poor prognosis in breast cancer patients, suggesting its involvement in disease development [PMC9091000]. Furthermore, knockdown of MAPT-AS1 has been found to decrease the stability of MAPT mRNA, while overexpression may protect it from degradation [PMC7521548]. Finally, there have been disease-specific effects observed between MAPT-AS1 and DNMT1 on the expression of MAPT [PMC4919105]. In summary, research suggests that MAPT-AS1 is involved in paclitaxel resistance and clinical prognosis in breast cancer. It may also play a role in Tau pathology and disease progression. Knockdown or overexpression of this lncRNA can impact cell migration, proliferation, and mRNA stability. The interaction between MAPT-AS1 and DNMT1 further influences gene expression. These findings highlight the potential significance of understanding the role and mechanisms associated with this lncRNA in breast cancer research.

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Sequence

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GCGGCCGCCGAGUCCGUCCACAUCGCCAGGCCAGGAGUCAGAACAAGGACGGGCCUGUGAUGUGUCUGUCUAUGACGAGGAGGACAAUGUCCUAAGGAAUGGAGAGGAAGAAAGUGAAGGGAACCAGGUCCCUGGAUUCCAUGUGGAACAGUAGCCCAGGAUGUGCACUAUGGACUGUUACAAGAGAGAGACAUGAUCUUCCUUAAGGCAUUGAUUUGUCAUGAGUCUCUUUGUUAUAGCCACUUAACGUUACCUUAAUACACCCACUUCAUGGAUAAGUAAAACUGAGGCUUGGAGAAGCCCACAUUGACACAGCAAAGAAGGCUGGGGCUCUUGUGCUGGUUAAAUGGACCUUGAUGUCUUCCAAAUGUUUUCAUGCUGGAUUCUGAGCCACUCUCCUGGCUGCAACUCUGAGGCCGGGCAGACUUUCCGCUGGAAAGAGAACUCAAAUACUGGUGAGAGGUGGAUUUGAAGCCAGGAGCCCCAGGUUUUGGCUCUGCAGGUUUGCACCCAGCUCUGUGGUGUAUGCCCUCACAGGUCACCCAGGACCUCCUGUCCAGGCUUCUUCAGGCCACCCAUGAUGGAGUAGAUUUGAGGAAUGAGGUUUUCAAAGCAGUUAGUGUGCGGGAGAGUAACCCUGGGGCCUCCGGAACCAGAAGGGAGGGAUUUGGGGGCUGGAGCUUGGCAGUCCAGGUUCCAUUGUCCUCAUGUUCUCCCCACUGGCCUGGCCUGUCACUCCAGUCUCUGCAUAGGUUGUCACAUGGCAUUCUCCCUGUGUGUCUCUGUGUCUCUUCUCUUCUUUAUAAAGACAUAGUUAUAAUGGAUUAGGGCCCACCCUAAAAAAAAAAAAAAAAA

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