ccr-mir-146a: Ccr-mir-146a is a microRNA that has been studied in various organisms, including Trachinotus ovatus, Cyprinus carpio, and Epinephelus coioides [PMC8375321]. In the common carp (Cyprinus carpio), ccr-mir-146a is one of the miRNAs that regulate gonad development and is up-regulated in the juvenile ovary gonad [PMC6636164]. It has also been found to be one of the most abundant miRNAs in both common carp liver samples [PMC4849022]. In a study involving common carp fed with a high-carbohydrate diet and administered with Momordica charantia saponin, ccr-mir-146a was among the differentially expressed miRNAs that played a role in regulating the insulin signal transduction pathway and carbohydrate metabolism [PMC10113649]. Additionally, ccr-mir-146a was predicted to target Gsdf and showed increased expression from the neurula stage to primordial gonads, peaking in primordial gonads and juvenile ovaries before decreasing in adult ovaries [PMC5410099]. These findings suggest that ccr-mir-146a is involved in various biological processes, including gonad development and insulin signaling. Further research is needed to fully understand its specific functions and mechanisms of action.
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