MIR4521: MIR4521 is a miRNA whose validity has been questioned and is found in miRBase [PMC5340965]. It has been identified as one of the upregulated genes in early diabetic nephropathy (DN) [PMC7759603]. In a study on colorectal cancer, high levels of MIR4521 expression were associated with poor prognosis [PMC7583989]. MIR4521 is regulated by STAT3 and was found to be overexpressed in HT29-derived tumorspheres [PMC7583989]. In the context of diabetic kidney disease (DKD), MIR4521 was identified as one of the miRNAs that may regulate differentially expressed genes (DEGs) associated with DKD pathogenesis [PMC8183707]. Additionally, a study on transfection used a pre-miR-4521 sequence for transfection purposes [PMC6754377]. In summary, MIR4521 is a miRNA whose validity has been questioned and is found in miRBase. It has been implicated in early DN and colorectal cancer prognosis. It is regulated by STAT3 and may play a role in DKD pathogenesis. The pre-miR-4521 sequence has also been used for transfection purposes.
Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset
View annotations in different species by clicking on species names.
Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.