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Homo sapiens (human) MIR2052 host gene (MIR2052HG) URS000075D880_9606

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MIR2052HG: MIR2052HG is a long non-coding RNA (lncRNA) that has been found to positively regulate estrogen receptor alpha (ERα) at both mRNA and protein levels through its interaction with LMTK3, thereby promoting cancer cell growth [PMC6448248]. This regulatory role of MIR2052HG is particularly relevant in estrogen receptor alpha-positive breast cancer (ERα-positive BC) and in the presence of the MIR2052HG SNP rs13260300, as well as in the context of aromatase inhibitor treatment [PMC7079433]. The study suggests that MIR2052HG plays a crucial role in maintaining the growth of cancer cells by enhancing ERα expression and activity through its interaction with LMTK3 [PMC6448248]. Additionally, the presence of the MIR2052HG SNP rs13260300 and aromatase inhibitors further contribute to this regulatory mechanism [PMC7079433]. These findings provide insights into the molecular mechanisms underlying ERα-positive breast cancer progression and may have implications for targeted therapies aimed at modulating MIR2052HG expression or activity to inhibit cancer cell growth [PMC6448248][PMC7079433].

Genome locations

Gene Ontology annotations

Sequence

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AGCAAUCAGCGAGAUUCCGUGGGCGUAGGACCCUCCGAGCCAGUUCCCGAGAGAUCCCAUGAUCCAGAGACAAAGGUGGCAGCUUUGGAGCAAGUGGAGAGCCAGAAAAGGAUCCAGAACUGGAGUGGAAGCUGAAGCUAUGCCAUCUUUUAUGUCUGAUGAGGCAGUUUCAUCUGAUUUGAAGAUGAUGAAGAAAAGUUCUUUGCAAGGUUGCUUAUUGAAUAUUACUGGGAAAACAGGAAAAUUAGGAGGAAUGUUCUGGAGUGAUUUAUCUUUUUCAUCAGGGGCCCGCGUUCAGUCCAGCCACCAGAUCAACACAUUCUCCAAACUCAUUAACUUUGGAGAGGCUACCCAGAGUUCCUGAAGAGUUCAUCUGAAAGUCACACAGCAAGAACACAGCAGAACAAAGAUUAGAUCCCAGCUUGGUCUUCUUCAAUGGUCAUGCUUUUCCAGAUACCUUAAAGAAAACCAAAUGGACAGUGAUUCUACACUGACAGAUAAGCAUGCUUAUAAUUGCUUGUUUGAUAUCUGUUUUUUCCCUGGUAGUUUGUAAGAUGUGAAAGAAAAAAUAUGUGUUGCCUUUUCUGACAGCCACUCCCCCAACCCCAGCACCUAGUAUAUAUUAUUUUCUAUUAGCUGUUAAAUAAAUACUUACCAUAUGAACAAGUGAACCUGAAUAAAGCAGUACUCAUUGGUCCUGGAGUGGAUGAAAUAGACUAGGGACUGGCCAGCUAGAAGGAUCAGGGACUCCCAAAUAUGUAGCAUUUUUAGUUGGUACUGAAUGUGUGAAUGAGAUGGGUAGCUAUGGCAUCCAGGCUAGGUGAAGUCAGUUAUAGGCAUGGAUGUGGAGGACUCUGUGGGAGGGAAAGAGUGAGUGGUUCAGGGCACUGGAGGUCAUGCAGAGAUUUGAUGCUAUGAAAAGCAAGUUGCACCUGUGAGAGUGUCAUUAGGUUAAUAACACCCUCCUCUUCUGUCUGCCUCCCUCACAAUCAUGAGGCUUGGAAAAGUGAGGGAUGGAAGUUAUUAUCUAGGAGCUUGUUCACUGCUGCCAAAAAUAGUUAGCUUUAUUAUGAGCUCUUGUACUGGCUUCAGACAGAGCCUUUGGGCAUCAUGGGAGUUACUGCUGCUUCCCUUGGGAACUACUGUCACUGCCAUGGGCAUCUGCAUCUGAGAAGCAUUCCUUCUCUGUGACAAUUAUCAUAGUAACUUUUGCCCAGCAAGUUGGCUUUUCUGGAUGUGUUAAUGAUGGUAAUAAUGAUAAUUGCUAAGAUUAUGAAUGUCUUGCAUGAAUUAUUUCAUUUAAUCCUCACAAUAACCGAAUGAGGCAGAAACAAUUUUGUGUCUUUUUUACAAAUGGGGAACUGAGAUUUGGGGAAGUUAAAUCAUUUGCCAAAGUCAUUUGUUCAAUGAUGAGUAGUCUCAAAAUUUUAACCCAAAUCUAAUCAACAUAUUGUAAGAUUGUUACAGUAAGAAUGUUAUUAGAACAUCCUGAGAAAGAGCUGAUAUACAUAUUAAAGAGUCCUUCAUUUUCGUGAUGCCUACUCCUUGCUUGGGUGCAAGGUUAUUUCUGCUUGUUGAUUCUGUCCCUUUGAAAAUCAGAUUUUAACCUCUAGCCUGCUAGUUCCUUUGUGGGGAAAAAUGAUUAUUGCUGUUUUCCAAAAUACCAAAAAAUGUCAGCCCAACCGCCUGAGUUUAAUCAGAUGUUUAAUCUGAUAUAGCAUCUGCAUAAUGACACCACAAAGAAUAAACAAGAAGAUCGGGACUGUGUCAUAAAUAUUGAUUCUUCUAUAGUCAGGGCCUGCUGACUUUCAUAUAAAACUUUUUAUUUAAUUAAAUCUAUUGCAAACAAUGCAGCAAAACCUUAUUCUAGUUUUAUCUUUCAGAAUGUUGAAAUAGUCACAGCCCAUGGAAUCAAUGUUUUGGGUAAGAUUUUUUUUAAUGGAAUUCUGUCUCUAUUGCUUUAAUUUCUUUAAUCUUUCACUGCAUGAAAAAUACUCUAAUAUCUUAAAAUUUCAUGUAUUUCCAGCCUAAAAAUAACAUCUAUUAUAGAUUUUCCUCAUUUUAUUGUGUAAAUGUAGAUAAGCAUAAAGAAGAAAAUAAAAAUUGUCCAGAAAGAACCACAAUU

Taxonomic tree

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Publications