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Homo sapiens (human) OTUD6B antisense RNA 1 (head to head) (OTUD6B-AS1) URS000075D817_9606

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OTUD6B-AS1: OTUD6B-AS1 is a long non-coding RNA (lncRNA) that has been found to have different roles in various types of cancer [PMC8569895] [PMC8716768]. In cervical cancer cells, OTUD6B-AS1 has been shown to promote resistance to cisplatin (CDDP) by up-regulating the expression of CCND2 through the sequestration of miR-206 [PMC8569895]. Conversely, in thyroid carcinoma, bladder carcinoma, and colorectal cancer (CRC), OTUD6B-AS1 has been found to play a tumor-suppressive role [PMC8716768]. These findings suggest that the function of OTUD6B-AS1 can vary depending on the specific type of cancer [PMC8569895] [PMC8716768]. In cervical cancer, it contributes to drug resistance by modulating the expression of CCND2 through miR-206 sequestration [PMC8569895]. However, in thyroid carcinoma, bladder carcinoma, and CRC, it acts as a tumor suppressor [PMC8716768]. These contrasting roles highlight the complexity and context-dependent nature of lncRNA function in different types of cancer [PMC8569895] [PMC8716768]. Further research is needed to fully understand the mechanisms underlying these diverse functions and explore potential therapeutic implications [PMC8569895] [PMC8716768].

Genome locations

Gene Ontology annotations

Sequence

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GUGACCCUGCCGUGAUGGGCGGGGCGGCAGGGGAGGAACCAGACUGCGAGCGGAGAAGCGGAGUUUGCAGCCUCGGAAUUGGCUAGAGCGCCAGAGCCGAGUCAGCCAUAAAGCUACGCGCUAGGCUCUUGGCCCUGACGUGAGGCGCGCAGAGAUGGCGUAACGGGAAUAGUUUUCAACGUCUAUUUCAUUCCCUGCUUCAGAGGACCUCUUUAAUCUUUGAUUUUGGUCCCUGUUUCUAAGAAAAGCAACUGAAAAGGUCGUAAUACCGCCCCUGAGAAAAAAGGAGCAGCGCUAAAUAAUCGAGAAAAUGCCUCCUCUUGAAACGGAUAUAGAGAUGGAAACAAGAUAUAAGAAGGAUUGAGAAUCAUAUAAUACAGGAGCUUAAACACCUAUGCGCGAUGAUAAAGAGGGUACUAUUAGAGCGCUUGGAAAAUACCAGGAAGUUGAGAGAGUUAACAGAAGGGCGCACGCUGGAUUGGCCACAAAAUCGAAUUACUGAAGGCCACUACUGAUUAGGACACUUAUGGAGAACGUGGGUAGCACUGAAGCAGCAUUCUAGUUUCCAGUGCCAUCAACCUCAUACGUAUCUACCUGGUCUCUGAUCGAAGCUACCGUAAUGUGUUCUUGAGGUCAACAUGUUUUGUGGAAGUCACUGUAUUUGCCCCUUUAUGUCAAUUACCUAUUAUAAACCGAGAGAAAUGGGAAAAUUAAAAACCUGUUUUGAAUUAUUUUUAAUGCAGAACUAUUUUUUCAAGUGAAAUCUUAUACAGAAGUCUGGUAUAUGAAACAGAUAAAAAUGAACCAAUGAGAUUGAAGGGAAUGAGUAGCAUGUAAUCCUGCCCACUCUUCGGAGAAUUUGAGGCAACUUUGUAGAGCCUUAGGAGUUCAGUUUGUAUGUUACUGGGUAAUUUAAAGCAGAAAUUUUAAUCUGACUGCACUUAAGAAUCAUCUGAAGUGUUUGUAUUGGUUAGUCUUAUUUUUAAUACUGAUGUCCUGGUCUCUCUCCCCUCAAAAAAACUCUGCUGCUGGGACCAAGCACAUAGAUGCUUUUUAAAAAGCUCCCGAAAAUGACUCUAAUAUGCAGCCAGGAUUGAAAAUAACUACCCUACACAGCAUUUUUCCUGAUUCUGAGCACUCAGCUUUUCAUUGAUUUUCCCUAGGGCAAGUCCUUCAUCUUAUUCUGGGUCCUUGUGUUUUCUUUCUGAACCUACAAUUUCUCCAUAGGUCCCAUGGUUUUCAAAAUUUCUCAUUUUCCAUUUUCUGUCCUUUUAUAUUACCUACUUGAAAACCACAGUCAUCUUUCAAAACAAAACACUGCCUGUUUCUUAGGUCUUUAUUGUGGGCUUGUUAUUCCUCAAUACAAAUUUACAUAAAAUAAUAACAAUUAAGACAUGGGCCUUGGUGUCAGAAUUAUUUUAUAUCUUUCUUAUUAACUCUGCAGCUUACCAGCUCUGGAUAAGUUAAAGGACAGCUAUAGUCUUACUACAUAGAAUCAUUAUAAGGAAUUGGUGGAGUGAUCCUUAUAAAGUGUUUGCAUGGUACCUAGCACAGAGAAAGUGCUUGAAGUUGUUAACUGUUAUGGUUACAAAAUAUGUAAAUAAUUUUUAUUGUCCAAUUUUCUCUCUUCAUAUACACUAAAUUGUUCUAAUUCUUGAACCACAGUAACAACGUGUGAAUGACUUAUGCAUUCAGUGUGUCCACUCAACUACUAUUUAUUAAGUACCUGUUAUGGUCUAUGAAAGGAACUGGCAAGACAGUCAUUAUUCCCCUUAAAUAUUCCCAAGUGUUAGUGGUCAAAGUUUCUCUCUGCUGAAAAUGAAAAGUACCCCGUAGGAUGGAGGAAACAGCCAUCUUGAGGGCUAAAUCUGGUCUAACAUAAUAUUUGUUGACCUGUUACUACAGUGUUGCCACAUAUGCUUUGUUGGUUUUUUAAUUUAGCCCCCAAACAUUUUAAAAAUCAGAUCAUUUCAUGUUAAAAGAAAUCUAGACUUCUAGUUCUCUUGCAAAUGUGAGCUCUGACAAACAUUGAAAUUAUAGAGUAGCAGGGGUAGUGUGCCCUUUAUUUGGUGCAUGUCUUCUGCAGGUUCCCAAGUUCUGCUGUUCUCUGUUGUUGCCUCAUCACUGAGGCCAAAUGUCAGUUGCUGCUUACAUGCAUUUGAACAGUUGUUAUUUUUUAUAGUGAAAUUAAAGGUAAACUGUUUUGAUAUCCAUGUUUCUACCAAAGGUAAGAAAACACAAGCCAAAAAGACACAGAUUUCAAAAAAAAUAAGAGAAAGCAUAAUUCUUUAUGGAAGUGAAGAAUAGUCUUUUUAUCUAAGUAUGCCAAAAAAAGCAUGUAUAAAAAAAUACAAUUUAAGAUGCCAUUAUGAAAAAACUCCAAGUCAGUGUUUACUAACAUCUUUUCAGUUUUAGGAAGGAGGCAGGUUGUCUUGCAUCUCAUUGGAUCUCCGGUACUACCUAUUUCUUGAAAUACCAUAAGUGCUAAUAUAUACUUGCAAUAGAUAAACAUGAGGAGUAUUACAAAUACAAGAGAUAGCAGGAACUAUUUUAAUAUUAAGAGAUAUCAAAUAUGCACGCUAGGAUUAAUAAAUGAAAUAAUUAUUUUCCUUCUUCUACAAUAUUUACUUAAUCUGGAGGCAGAAAUACAUGUUGUCUCUCUUCCUGCUUCUCCAUCAAAAUCCCGACCAAGUAAUCAGGAUCUUUGAGAAUCACAAUAAGAAUUACAGCCUCAUGUUUGGAUUUUUUAAAUUUAAAUUUUAAAUUACUCCUUUCCACUGAUAUUUAUUGAGAAACUGCUAUGCUCCAGGUACUGCGAUAAACACUGGGCAAAUGUUGGAGAGCUAAAAAGGCAUAUUCCUCUUAUAAAGACAUUAUUUACUUGUAACAAACAAGUAAAUAAAUGUAUUAGUCAAUAUGUAAGUAAACAAAAAAAUGGACAAGCACAAAUUAUAUUAAGUACUAUGUAGGAAACCAAUAGAGUACUGUAACAGAAUAAUAAGGUAUAUGGGAUGGGGGUGGGAAUCUGUUCAGAGAUGAUCUACCUGAGAAGGUAACAUGUAGGCAGAGAUCUGAAUCGUGAGGAGUCAGCCUUUCAGAGUAAGUGGAGUAGGCACUUCCAAGAGAAAAGCAUAUUCCUGGCUAUUUGCCUAUCAAUGUCAUCUUGAACAAGGGUUAGCAAUCUCCUACCUGUACCACAGAUGCUAUGUGCCACCUCCAUGCUACCUUUGCCACCAAGAGAUUCAAUGUGAUGCAUGAUUUGAAGGUUCCUCAUCCUGAUACCCUGUGGAAAGUAAAAUCAGUGACAAAUAAAAGCAGAUCAUUAUCUCAGGUAGAGUCUGCUAAAGAUGAUACUUGCUUGUCAGUACAUGAGUAUCCACCCUAGUAAAAAACCACAGAAGAAGUGGGAUUUAUCUUCAAUGUUCUCUCACUUCCCCUUCCAAGUGCCUCUCCUGCCUUCUGAUGCUCUUUCCCACAAGUUGCAGGCAAAUAAAGCAUGUAUAUUACUCUCUUUUUAUCCAGAGUUGCUCCUUGUCCUUAUAUGAAGUAGAUUCCAGACCUCACAAUUGUAUAUGCCUACCCUUCUACUCCAACCCCUCAAAAAAAGAGGAAGAAUGAAAGAAUGAACAAGAGAAAAGGAAGGAAGAGAGGGAGAGAGGAAAGGAGGGAAGGAUGGUCCUGAAGAUCACAGUUCGGUGCUGAAAAAAGCAUUUCUAUUAAACUUCAAGACAGAAUGAAUGACCAUAGCUAAUAAUGUACCUUAAGCUUUUCUAGAAUCUUUGUAUUAAAAAAGUUGAUUGUUACUAAAUGUAUUUUAAUCUCAUAAAAUUUUAGGAAUUUAAAUGAAGAAUUUCACAAAGGGUAAGAAAAAUUAUAUAUUAUAUUUAUAAAUUUGUCAUUAUGAUUCUCCCAUUGUGGAAAAAAAAACAAAAUCUCGGUACCCCAAUUCACAAAGCCAAAAGGAAGAAAGUAAGCUGAACGCUGAGUCAUGCAAGAAACUGCUCGCUUUUGUUCCUAAGCUAAUAGCUACAGAUAAAAGGUCAGAUAUCUCCAUAGGUAGGUACUCUAUGUUCACCUUAUGUAAAGUGCCAAUUUAUUGAGCGUAAGAGGAUUACCUAAUUGACUAUUCCCCAGCCUGCUCCUUUUCUCUUGCAACACAUGGAGUCAGCAAUGGGACCAUAUCCUCUCUCUUUCCCCUCCAGCCUGCUUUCCCCCUUUAAAUACUGAAGCCCUCAAAAUCAUCUUUCUAAAAAGGUAUGAACCAUAGAUUGUUCCUGUGGAUUUGUGUUUCUUUCUUCCGGGCAUAUCCUUAAGCUUGGCAAAAUAAAAUUCUAAAUUGAUUGAAAAAAAAAAAAAAAAAA

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