LINC00111: LINC00111 is a tumor-suppressive long noncoding RNA (lncRNA) that is negatively regulated by the TXB2 transcriptional complex [PMC9776013]. It interacts with ZNF217, a novel interactor of TBX2, and is bound by TBX2 and ZNF217 on its promoter [PMC9776013]. LINC00111 is one of the two long noncoding RNAs (lncRNAs) that have integration events observed in breast cancer cells [PMC8076016]. Loss of TBX2 or ZNF217 function leads to the upregulation of LINC00111, along with six protein-coding genes [PMC9226508]. The repression of LINC00111 by TBX2-CoREST complex is important for breast cancer proliferation and survival, as breast cancer patients with LINC00111-overexpressing tumors have better overall survival compared to tumors with downregulated LINC00111 [PMC9226508]. The LINC00111 promoter contains a CREM motif, which is less commonly occurring in TBX2 binding sites overall [PMC9226508]. Knockdown of LINC00111 rescues the antiproliferative effects of TBX2 siRNA and prevents upregulation of p21WAF1/CIP1, a pro-senescence factor [PMC9226508]. It remains unknown how LINC00111 manipulates the expression of TBX2 and p21WAF1/CIP1, but further research is needed to determine if CREM motif plays a role in transcriptional repression by TBX2-CoREST complex on the LINC00111 promoter [PMC9226508]. Overall, LINC00111 acts as a negative regulator of cell growth and positively correlates with p21WAF1/CIP1 expression in growth arrest associated contexts [PMC9226508][PMC8798172].