v24

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Homo sapiens (human) long intergenic non-protein coding RNA 2470 (LINC02470) URS000075D3CE_9606

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LINC02470: LINC02470 is a long non-coding RNA (lncRNA) that has been studied in the context of bladder cancer [PMC8870681]. In T24 cells transfected with a miR-143-3p inhibitor, the expression of LINC02470 and SMAD3 mRNA was found to be higher compared to cells transfected with a miR-NC inhibitor control [PMC8870681]. Further investigation revealed that LINC02470, along with another lncRNA called LINC00960, is present in exosomes derived from high-grade bladder cancer cells [PMC7349410]. These exosomes were found to promote malignant behaviors in low-grade bladder cancer cells and enhance the epithelial-mesenchymal transition (EMT) process [PMC7349410]. Additionally, the expression level of LINC02470 was higher in the shNC group compared to the sh2470 group, as determined by RT-qPCR [PMC8870681]. These findings suggest that LINC02470 plays a role in bladder cancer progression and may contribute to the aggressiveness of low-grade bladder cancer cells when transferred through exosomes [PMC7349410]. Further research is needed to fully understand the molecular mechanisms underlying its effects and its potential as a therapeutic target for bladder cancer.

Genome locations

Gene Ontology annotations

Sequence

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GUGCAUGCCCGGCUGCCGUUGCUGCCCCUGCCUCGUACAAACGUCAGAGAAGGCACAUGACACGCCCCUGGGGGCCAUCUGGCCCAAGUCCACCUGCGCGGCUGAGUGGAGGAUGCUAGGUUGCUGUGCUGUUUCUCCUACUGUCUUGCUGCCGCACCACCCCUCAGAAAAACCGGGUCGUCAGUUUCCUGCGGUUUGCACUCACCAAAUAUACUUAGCAAUUUGCAAUUCACCCGCAGGAUUAUUCCAGCCUCUGUGAUCACACACAGAAGGAUGAGCCUUCCUCGUGAGGGUUGGAGAUGGAGGGAGAAGGGAUGGAGAGUAAGGAUGGGACGGAGGUUGUGGAGCAGCAGACCAACACGCCAGAAAGGAAAAUAAUGAUCAUCUCAAUUUUUAUAUGUGGAGGCAUUGCUUUUCUUCUUUGGGGGAUUUUAAGAUUUCCCAGAAAAUUUGGAAUUCCAAGGCACCUUAGAAACAAGACAUGCCUAGAAAAUUUGACUAUGUGUCCACAAGGCUGGAACUGAAUCAAUAAUAAUUGCUUCUUUCAAUCUGAACAUGAAACAACGUGGAUCAAUGGCUGAGAAAACUGCAGAAGUUAUGGAUCUCUGGCCAGGCUCAACUCUCAGAAUGAAAUGGGAAUCUUUGAUGCAUUAUCUGGGGCCGUCUUUAUAUUGGUUUGAACUGAGCAAGCACAAUGCAAACAAAACGUGGAUGUGGGCAGAUGGAGCUACAUUCAGCAAUUGUGAAAGAAUCGAGUUUUGUGCUAUGAGUCAUGGGAGCAAAACGUGAGUAUUUAGAAGUGGAGAGGACCACGAAGAAGGAAGCCCUGGUGACUUGAAGAAAUCAUGGAGAGUUCUCCGGAUUCCCACAAACCUAUGGGGUUUAGAUUCCAGCUAAUACUUACACGGGUCUCAGAAGGACAGAGGGCAAGGGUUAACAUCUGGCUGAUAUUAAAGUCUCUGCACCUCUUAAUAUUUUAAAAAAAAAAAAAA

Taxonomic tree

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Publications