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Homo sapiens (human) long intergenic non-protein coding RNA 239 (LINC00239) URS000075D38E_9606

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LINC00239: LINC00239 is a long non-coding RNA (lncRNA) that has been studied in relation to ferroptosis, a form of regulated cell death [PMC9424287]. Knockout of LINC00239 has been found to sensitize cells to ferroptosis, as indicated by reduced levels of the antioxidant glutathione (GSH) and its oxidized form (GSSG), along with increased accumulation of reactive oxygen species (ROS), lipid ROS, and Fe2+ [PMC9424287]. Additionally, the knockout of LINC00239 has been shown to increase cell death in response to erastin induction [PMC9424287]. Conversely, when LINC00239 is knocked out, there is a strong inhibition of Nrf2 translocation into the nucleus under erastin treatment [PMC9424287]. These findings suggest that LINC00239 plays a role in regulating ferroptosis and Nrf2 translocation in response to erastin treatment. Further research is needed to fully understand the molecular mechanisms by which LINC00239 influences these processes.

Genome locations

Gene Ontology annotations

Sequence

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UGCCUUUCACCUUCUGCCAUGAUUGUAAGGCUUCCCCAGGCCCGUGGAACUGGGAGGAGCCGGAAGAGAGCAGUGCUUCACAAUAAAAGGAAGAAUUGCUUGAACGGAGGCGUUUCAGGCAUGAGUCACAGGCCGGGUGUGGAAGAGGAAAGUGUGAAGCAAGGGACAGGUACCAGCUGGGAUGUUGGCAGCAGCCGCUCCCCUGCAAGGAGAACCUCCCACUUCCUGUCCCGCACACCUGCCUCAUUGGAAAGUGACGCACCCACUGUUUGGCCUCGGCAGCCUGAUGUUUCUCAUCACACAGGAAGACGGUCAUGCUACAGGAAGACCUCGGACUUUGCAUCCAGCAGAUGGUUGUUCUAGAGAUUGUCAGACCGAGACCACGCCACACACCCAGAAGGCACCCAAGUCACAGAGCCUGAUAUUGUUCCUGGAGCGCCAUUGCAUCAUCCUUGACCACAAGAUCUGCGUCAUUGGAUUUGUCUCAAAAACUUGGGACUCUGGAGAUAAAACCUCAUUGCAAGGCUACCUUUGCCACUGUAUCUUAGCAGCUUUUGAAGCAAAGCAUUUCAAUAUUUAGACACUGUGUUUCUAAUGGGUACUGGGAUCAAAAUAAUAAAAACUCAGUCUGCAAAGGGAGAAAAAAAAAAAAAAAAAAAAAA

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Publications