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Homo sapiens (human) FRY antisense RNA 1 (FRY-AS1) URS000075D28F_9606

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FRY-AS1: FRY-AS1 is a long non-coding RNA (lncRNA) that has been studied in relation to glioblastoma (GBM) and pyroptosis. In a comprehensive analysis of gene expression in GBM, FRY-AS1 was found to be abnormally expressed and related to overall survival (OS) [PMC7773845]. FRY-AS1 was identified as a suppressor gene, along with LNC01545, WDR11-AS1, NDUFA6-DT, and TBX5-AS1 [PMC7773845]. In another study focusing on pyroptosis-related lncRNAs, FRY-AS1 was identified as a protective factor [PMC8866949]. Furthermore, FRY-AS1 was found to be negatively correlated with hsa-mir-193b in a regulatory axis centered on this microRNA [PMC9018166]. The LASSO Cox analysis identified FRY-AS1 as one of the 15 lncRNAs included in the pyroptosis-related lncRNA signature [PMC8866949]. The research by Niu et al. also confirmed the protective role of FRY-AS1 [PMC8866949]. Overall, these findings suggest that FRY-AS1 is involved in GBM and pyroptosis processes and may have potential as a therapeutic target or prognostic marker.

Genome locations

Gene Ontology annotations

Sequence

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AAAGGACACGGCGGAGCAGAGAGAGAUGCUCGGCCGCUCCUCCUCCUCCGGGUCCAGGACUUGCUUCUUAUUUGCUGGACGCUGAUCUCCCUGCAGCCCUCGGAGGCGGCGGCCGCGCUGCUUUCAUUUCGGGGCUGUCAUCACCAGAAACGCCGGCUGCCGGCCGCCCACCAGCUCGGCUCCAGCCAGGCAGUGGUCUCUACAAGGAUGUCUGACCUAGAGUGGAGAUGGGGUGACUGAGGAUGGAAAUCUAGUCUGAACUCCACUCUCCAAUUUGGCAGAAGACCUGUGUCUUACUCAGCUUUGUGUUCCUUACAUCUCUGUAGCACACACUCCCCUGCGAAGGGGUUUUAUAAGGAACCCAGAGCCAAGACAAAGGAAUCAGGAGGAAUUCUAGCACAAUGGGAAGCCCCUGAAGGGUUUAAGCAGAAGACAAUAAAAGACUCCGAGAAGUGGCAGCAGGGAGUGGAGGAAAAAAAGCCUGGAAUUUACCCUGCUUUCUGCUCUGCACAUGGAAUGCCCCCUCCAUGUGUCCAUUGUCAUCCAAGGUGUUUUGACAGGUCUAGAGUGGGGUAAAAGAAUGGUAUUUAUUCAGGCCUAAUAUUGAGGCUUGGGGCUGGGCUGUAUAUCAGAGGGCAUGCAUAGACAAAGCUGAACAAAGGGGCACACCUACUGGGCACCUGCUGGGCACUUCUCUAAAAGUGGCACUGAGACAUCAUUAGGAUGAAUUAGAACUAGGGCACCAGUUAACCCGGGCCUGCAUGCUAGUGAAAGGAAAAUUGCGCCUCUCCCUCAACCCUGCUCCAGACAACUGAAUGGUGACUUCAAGAACAAAUAUUCAGGCUGGGUGCGGUGGCUCACACCUGUAAUCCCAACACUUUUGGAGGCUGAGGUGAGUGGAUCACCUGAGGUCAGGAGUUCGAGACUAGCCUGGCCAACAUGGUGAAACCCUGUUUCUACUAAAGAUACAAAAAUUAGCUGGGCGUGGUGGUGGGUGCCAGUAAUCUCAGCUAGGAGGCUGAGGCAGGAGAAUCGCUUGAGCCUGGGAGGCAGAGGUUGUUGAGAUGGUGCCAUUGCACUUCAGCCUGGACGACAAGAGCAUAACUCUGUCUCAAAAAAAAAAAAAAAAAAAAAAGAACAAAUAUUCAAAGGAUAUUAAUUAGAAGGGGAGUGACAUUGUAGACCAGACCAUGCUCCAUCAUAUAAAAGCUGUAUUGUUGGCAAAGUUGUUGAGCAUCUCAUGGCCUCAUUUUCCUCGUCUGUAAACUAGUGCCUUGUCACACAAAUCUGUUAUGAGGAUUACAUGAGUGCCUAGGCAGAUGACAACUGUUAUGUAGCAAAUCUGUAGUGAGAAAUGAACCCAGAAUAUGCAGCACAAAAUGCCUCCUUAACUCCAUAGUCAGGUUAGAAAAAGAGAAGAGAAGGAAAGAGGAGAGAGAGAACCUGUCAUCAUAGAGAGAUCCCUACCCCCAACCCCCUCUGCUGGCUACCAAGGUAAGGUAGACCUGCCCACAAGGCUGGAAGUUUCGGAAAGGUAAAGAAAGUCUAAACACAUGCACAUACAAACACUAUUACUUAACAUUUUAGUAAUAUUAAGUCAUAUAACAUUUGGUGCCCAGGGUAAACUUCCAUUUGAUUAGAGGUUCCGGUUAGGUUAGUAUCAUCUCAAAAUUUACCUAAUUUAGUCUUCUCAUCAACCUCUCAAAGUAGUGUCUGCAUAUUUGGAUAUCAUUAACCUGUAGUCAAAACCAGGAGAUGUUGUGGUUCAUACAUAUUUUGUACACAUAAAGAUUCGACUUCAAUUUCUGCAGAAUAAGGUCAUAGCACACUUAGUAUUUAAUGUAUUUAAAGACAUGUAUGCAAAGAGAAAACAUGACAGCAUUUACCUCAUGCCCCUUAGCAUGAAAGCAUACAACACUAAUGAUAACUUUAUUAUCCUAUUUUUGAAUAUCACCAGCAACCUGAGAAAUUAUUUACGUUCAGAUACAAACAGGUCAAAUAUAAAUGGCCACAAUAGGAGCCAACUAUUAAUACAUAAUUAUAAAAUAUUAAGUCCCUUCUGAAGAAGCAAAAAAUGGCAUUUGCGGCUGGGCACGGUGGCUCACGCCUGUAAUCCCAGCACUUUGGGAGGCCGAGGUGGGUGGAUCACCUGAGGUCAGGAGUUCAAGACCAGCCUGACCAACAUGGUGAAACCCCAUCUCUACUAAAAAUACAAAAUUUAGCUGGGUGUGGUGGCGGGCACCUGUAAUCCCAGCUACUCGGAAGGCUGAGGCGUGAAAAUUGCUUGAACCCGGGAGGUGGAGGUUGUGGUAGGCCGAGAUCCUGCCACUGCACUCCAGCCUGGGUGACACAGCGAGACUCCAUCUCCAAAAAAAAAAAAAAA

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Publications