v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) Down syndrome critical region 8 (DSCR8) URS000075D1D9_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

DSCR8: DSCR8 is a long non-coding RNA (lncRNA) that has been found to be negatively correlated with overall survival in various studies [PMC7748909]. One study aimed to investigate the activation of the Wnt/β-catenin signaling pathway by DSCR8 through the DSCR8/miR-485-5p/FZD7 axis [PMC6113322]. In a study analyzing gene expression, DSCR8 was among the most significantly overexpressed genes in various cancers, including gastric cancer (GC) [PMC7349095]. This suggests that DSCR8 could be used for the diagnosis and targeted treatment of GC [PMC8430047]. Additionally, a negative correlation was observed between DSCR8 expression and miR-137 expression in GC patients [PMC8430047]. In ovarian cancer (OC) tissues, DSCR8 was found to be upregulated while miR-98-5p was downregulated compared to adjacent normal tissues [PMC7492662]. This indicates that DSCR8 may function as a molecular sponge for miRNAs [PMC6113322]. References: - [PMC7748909]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748909/ - [PMC6113322]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113322/ - [PMC7349095]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349095/ - [PMC8430047]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430047/ - [PM7492662]: https://www.ncbi.nlm.nih.gov/pmc/articles/PM7492662/

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
UAGCGCGCAGGGAAGGCUGGUCACCCCACCCUAAUCUUGUUAUGCAAAUAGGCUUCCCACUUGGCAGGGGCCGUCUUGUCCACUCGUUUCUGUAAACAUGGGUGGCAAAAAGAGAAGAUGGAGCUGCCAUUUAGAACAUGCCUAAUCCCAGCUUCAUCUUGCUGAGCAAAAAUGAAGGAGCCUGGACCCAACUUUGUUACUGUGAGAAAGGGUCUUCAUUCAUUCAAGAUGGCAUUUGUUAAGCACCUACUGUGAGUAGAUGAUCUCCUGUCAAAGACAGUUAACAAAUCCUCGGAAUAUUGCUUCAUGUACAGUUAUUGGAGAUGAGUAACUUACAUUCUCUUAAUUGUAAUGGUUCCUUGGAAAGUCAUCGUGGAAAAUGAAGGCUGGCUCAUACAUUUUCCCAGACAGGAAUUUGGCUGCCAACAGGGAAUUCUAAACAACUAAAAACUCCAGAUGAUGAAUGCACAACAUAAUGAUGGUUAAAUUAAAAAAAAAAAAGAGCACGGCUGGAGUGCAGUGGUUCAAUCACGGAUCACUGCAGCCUCCACCUCCCAGUUCAAGAAAUUCUCAUGUCUCAGCCUCCUGAGCAGCUAGGAUUACAGACAAACCUUGGAAAUCAAGAAAGUUCUGGAAUGAUGAAGCUGUUCAUGCCAAGACCGAAAGUGCUGGCCCAGUAUGAGUCCAUUCAGUUCAUGCCGUGACAAUUUUCUUGGAACUCCUUUUUAUUGUUAGUUCUCACUUGUUUCCAUAUUUAGUGAAUGUACAUUUAAUUGCAAAGCUGUCAUUAAUAAAAAUUCUUAUAGUACCUCAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications