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MIR4647: MIR4647 is a non-coding RNA that is located within the 3'-UTR of the SLC35B2 gene [PMC9296583]. It is one of the eight upregulated miRNA sequences found in non-protein coding genes [PMC5823624]. The effects of MIR4647 on cell migration and colony forming were analyzed by optimizing the transfection process of corresponding miRNA precursors [PMC9843305]. The perturbation of MIR4647 by a miRNA inhibitor did not suppress the cytopathic effects of HSV-1 infection [PMC9296583]. The genomic locus of MIR4647 overlaps with the 3'-UTR of SLC35B2, suggesting that sgRNAs targeting MIR4647 may reduce the expression of SLC35B2 [PMC9296583]. In a screen, MIR4647 was identified as a candidate miRNA, along with three candidate genes (IRF2BPL, PAPSS1, and VANGL2) [PMC9296583]. Overall, MIR4647 is an intragenic miRNA residing within an upregulated gene and its role in cell migration and colony forming has been investigated [PMC5823624] [PMC9843305] [PMC9296583].
References:
- PMC5823624
- PMC9843305
- PMC5069896
- PMC9296583
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