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Homo sapiens (human) HOXA transcript antisense RNA, myeloid-specific 1 (HOTAIRM1) URS000075CF47_9606

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HOTAIRM1: HOTAIRM1 is a long non-coding RNA that has been found to play a crucial role in various biological processes, including osteogenesis and neurogenesis [PMC6815819] [PMC6923663] [PMC7359305]. In terms of osteogenesis, HOTAIRM1 positively regulates the differentiation of mesenchymal stem cells into osteoblasts [PMC6815819]. It has been shown that HOTAIRM1 depletion leads to a reduction in the expression of osteogenesis-associated markers, such as SP7 and SPP1 [PMC6815819]. Furthermore, HOTAIRM1 expression is significantly increased in mesenchymal stem cells after treatment with an osteogenic medium, indicating its regulatory function during osteogenic differentiation [PMC6815819]. Mechanistically, HOTAIRM1 has been found to be associated with the MAPK/JNK pathway, which is crucial for osteogenic differentiation [PMC6815819]. In terms of neurogenesis, HOTAIRM1 has been implicated in the differentiation and maturation of dopamine (DA) neurons [PMC8306845]. It has been shown that HOTAIRM1 levels increase during DA neuron maturation and are associated with the expression of DA neuron markers such as TH and DAT [PMC8306845]. Knockdown of HOTAIRM1 leads to decreased levels of DA transcription factors and delayed DA neuron maturation [PMC8306845]. In addition to its role in osteogenesis and neurogenesis, HOTAIRM1 has also been implicated in tamoxifen resistance in breast cancer. It has been found that overexpression of HOTAIRM1 contributes to tamoxifen resistance by upregulating its target gene HOXA1 [PMC7150441]. Overall, these studies highlight the diverse functions of HOTAIRM1 in various biological processes.

Genome locations

Gene Ontology annotations

Sequence

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AAAAGUUUGCCGGCUUCCGCAGUGAUGGAUCACCGUUUUAGUGGCAUUUAAAUCCCCGGCGCUCCGCCGUCUAGGUGACGCGCAGUCGCCCCCCCAGGCAGCCUAGGCGGCGGCAGCUGCUGCGGCGACUGCAAAGGCCGAUUUGGAGUGCUGGAGCGAAGAAGAGCAAAAGCUGCGUUCUGCGCGCGCCCGACUCCGCUGCCCGCCCCGCCAGGCCUCCGGGAGGUGGGGGCUGGGAGGCGUCCCCCGCUCCCGCCCCCUCCCCACCGUUCAAUGAAAGAUGAACUGGCGAGAGGACGAAUCGCAUCCAGGAGCUGCGCAGCCCUGGCCGCUGCCGGGACGCCCUGCUCCGCGCUGAGCUUGGGGCCAGAAACCAGCCAUAGUCCCCACACUCCGCCGCCGCAGCUGAGAUUUAGCGGAGGAAGGGGCGAGGGAAGGUAGGGAGCAAACCUAUGAAGAAACAUCGCGUUGUCAUUGGAACUUCCAAGCCUUUGCUGUUAAGAGCCAGGUUCUUAAAUCAACCCGCCCCACACACAUGUUGCUUACAUGCUGCGUUUUCUCACGGUCUGUUUUGCCUGAACCCAUCAACAGCUGGGAGAUUAAUCAACCACACUGAAAAUGUGGAGGGAUUUAUGGGGGAGGGGGUUGAAAUGUGGGUGUUUGAAACAAAAGUGUAUAAACAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUAUUAAAGAAACUCCGUGUUACUCAUUCCUGGAGUUGGGGGUUUCUGUAGGCACUUUAUUUCUCCACUUUCAAGAGCUUGGGCUUGGCCCAAAUCUUAGACUGUCCAAUUCUGCCUCUAUUACCAAUUUAAAUCUAUGGCUUGAACCUGUGCACUGAAAAUCAAAUCCUUUAAAAAGAAAGAGGAGAAGAAGAAGCAAAAAAGAAAGAAAAAACACUUAUUAGAAGCCCUAGUCAUUUUUUGGCUUUCUGUUUUGUUGCUGUCCAUUGAAGACUUUGAACAUGCCGCCUUAAUAAAUGUAUUAAAAUUGAAAAAAGAAAAAAAAA

Taxonomic tree

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Publications