MIR650: MIR650 is a miRNA gene located on chromosome 22q11.22. It has been found to be significantly deleted in various cancers, including chronic lymphocytic leukemia (CLL) and colorectal cancer (CRC) [PMC3938728] [PMC4897824]. MIR650 is known to be directly regulated by Tumor Necrosis Factor (TNF), a group of cytokines that can induce apoptosis [PMC3938728]. It has been shown that MIR650 plays a role in the transcriptional regulation of MGMT, a gene involved in DNA repair and resistance to chemotherapy [PMC8010678]. Additionally, MIR650 has been implicated in the regulation of various other genes and pathways involved in cancer progression, including ING4, CDK1, and EBF3 [PMC3938728]. The dysregulation of MIR650 has been associated with tumor invasion and metastasis in renal carcinomas [PMC3726994]. Furthermore, studies have shown that the expression of MIR650 is negatively correlated with the mature state of dendritic cells during influenza A virus infection [PMC8779696]. Overall, MIR650 is an important miRNA gene involved in various biological processes and its dysregulation has been implicated in multiple cancers.