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Homo sapiens (human) small nucleolar RNA host gene 18 (SNHG18) URS000075CB75_9606

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SNHG18: SNHG18 is a long non-coding RNA (lncRNA) that has been studied in various contexts [PMC8691457]. In collected HBV-HCC tissues, the level of SNHG18 was significantly lower than that in normal tissues [PMC8864170]. SNHG18 has been implicated in radioresistance, as lncRNA HMMR-AS1 upregulates the phosphorylation of ATM and the levels of DNA repair proteins, including RAD51 and BMI1 [PMC10003080]. In a study that examined 14 lncRNAs, SNHG18 was one of the lncRNAs identified [PMC8691457]. Mechanism studies have shown that SNHG18 promotes the transcription and expression of p21 by inhibiting c-Myc expression, leading to G0-G1 arrest and inhibiting the proliferation of bladder cancer cells [PMC10018893]. In glioma cells, SNHG18 was found to regulate cell motility by disrupting ENO1 nucleocytoplasmic transport [PMC6865306]. Additionally, SNHG18 has been shown to have an inhibitory effect on anchorage-independent growth in human breast cancer cells in vitro and on xenograft tumor growth in vivo [PMC10018893]. In a high-risk group, the expression of SNHG18 was increased compared to other lncRNAs [PMC8365518]. Finally, SNHG18 has shown potential as a biomarker for differentiating hepatocellular carcinoma (HCC) from cirrhosis with an AUC value of 0.7702 [PMC6104208].

Genome locations

Gene Ontology annotations

Sequence

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CUCCUCCUCCUCCUCCUCCCCGCCGGGGUGAAACUCGAGCGCCCCACCCGCGCCUGACCUCCCCGAGCCCCUCCCCGGGCCCCGCCCCUUCCCGGUACAGGACCCCCACCUUCGCUCCUGGGAGCCCCGCUGCACCCCAGGAGUUCCAUUCCAGCCUCCCCAGUGCGAGUGCGGCCGAGCGCUGACUUUUGGGGGCUCCCUCCCCCGUCUCACUGGGUCCCUCUGCGGCUCCCCCGCCCGCUGUCCCGGUUCAGACGUGGCUGCACCCCGGAGGGGGGCGCCGGCCGAGACCUGAGACGUGGCGCUCCCUCUCUGCCGGCCUCGGCUUCAGUGCUUGAAUUUCAGCCACAUCCCUAAGCUGCCAUCUCAGACCAGAGGAACAGGGAGGGGGGCUUUCUGGAAAGAACAUCACCUGGAAGAAAUCAGGACAUGACUGUGGGCCAUGAGUGACCUUCAAAGGAAAGCCGGGUAUCUGUGGUCUUUAAGAUGUGAUCCAUGACAUUUAAAAACUGAAGAAAUGGAAAGAUCAUCUGAUCAGGCCCAUCAGUCUUUUUCCUAAUGCUAAACAUUGGUACAAAGACGUGAAGUUUGAUGUCUCACUAAGAUUGCCUAGGGCUGCUUUAUUGCUCACCUACUUCAAAGUAUUGGGAAAACAUGAUUAUGGGUACAGGUGAUGCUGUGUUGCCCCCAGACAGGUUUCUUUUGUCAGGUUCUUUUGAUGGAUUAGGAACCUACAAGUGGGGAGAUUUUAGGGAAAUAGCCCCUCCACUUGGAUUUCACCAAAACGUCUUUAGGGUUCUCUUACCCCAAGAAACACGCAUUCCUCUUUAGUGUGGCAGCCCACUCUAUUGGCAAAGUUAAGCAGACCAGUUUUACUAAAAAGGAGCCACCCAGAAACUUAGACAGAAAAUACUUGAGGCACAGAUGAGAAUGAGCACAAAUGUGCAUAGCAAGUGCAGUUUCCUGGCCCUUAAACUGAAGGGCCAGGUCAGUCUGCUCCUCCAGGCACAGCCUGGGACCCCAUCAUGUGCCCCACUCUGCAGUCUGAGCUUCCACUCAAGUCCACCAGGGCCUGCCUCACAUAUAUAUACAAGACCCAAUGUCAGAGUCUGCCUCUGCCCAUGUCUGGUCAGAGGGUUGCACUUUGCCACUGCUACAUGUUCCCAGAGGUUGGCACAGCAUGACCUGGACCUCACCUAACCCAGGCAAACUCUGCUCAUCUUCGAGCUCUCUGGAACCCAUUUCUCAAGGGAGAACCACAUUCCCCCACCUCACAGCCAAGUUCAAGGAAGCAGCCUGGCUAAAGCAAUGACUCAAGGAUACCAGAAGCAGAGCACGCAUUUAAGAAGAUGCGCUGACUCGCAGGAGCAGCUGACUCUUCUUAAGAAGAGUUUACUGAUUCUUCUUUCAGUACGGGCCUUUUAAUAAGAUAUUGUAUUUUACUUCAGCUAUGGGUGCAGACAAUUAAAGGAUUCUAGAAAUCUGAAAAAAAAAAAAAAAAAA

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Publications