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Homo sapiens (human) long intergenic non-protein coding RNA 1198 (LINC01198) URS000075CADA_9606

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LINC01198: LINC01198 is a long non-coding RNA (lncRNA) that has been found to play a role in various types of cancer, including glioma, colorectal cancer (CRC), and breast cancer [PMC6738407] [PMC9558410] [PMC7571838]. In glioma cells, LINC01198 has been shown to enhance AKT activity by promoting the degradation of PTEN through NEDD4-1-induced ubiquitination [PMC6738407]. In CRC tissues, LINC01198 is upregulated and has been found to regulate Notch-pathway markers such as Notch1, p300, and Hes1 [PMC9558410]. Additionally, LINC01198 is upregulated in glioblastoma and has been associated with clinical outcomes in this type of cancer [PMC7571838]. Furthermore, a study investigated the correlation between LINC01198 activation and MHC-I/CTL signatures in an unknown context. The Pearson correlation coefficient was calculated to assess this relationship [PMC9728976]. Finally, in breast cancer models, it was found that LINC01198 regulates the immune response by interacting with p65 and activating it. This suggests that LINC01198 may play a role in modulating immune responses in breast cancer [PMC9728976]. Overall, these findings highlight the diverse roles of LINC01198 in different types of cancers and its potential as a therapeutic target or biomarker for these diseases.

Genome locations

Gene Ontology annotations

Sequence

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CUCUCGCCUGCCUUCGGCCCUUAGGCUCCGGGAGAUUGCAAAUAACCUGCUUUCUUUCUGUUCCCAGGUGGCGUCGGACCCCUGUCAGAGAGUAAAUCUCAAGUAAGGUACCUGCCAUCGGCAGAUUUGAGCUUUCUUCUUGGACACCUAAUACCCACAGUCCUCCAGGCUCCGGUAGACUGCAAAUGACCUGCUUUCUUUCUGUUCCCGGGCUGCGUUUGGACCCCUGUCGGAUAGUAAAUCCCAAGCUCCGGUAGACUGCAAAUGACCUGCUUUCUUUCUGUUCCCGGGCUGCGUUUGGACCCCUGUCGGACAGUAAAUCCCAAGAAUGGAACAGAUAAGAAGAUACUGAAAUUGGACGGUGCUGCCGUGCGGCUGCCGCAGGACACCUUUAAUAUCCCUGUUUCUCAGGCUGUAGAUGAAGGGGUUCAGCAUGGAGGUGAUCACCGUGUACAUCACUGAGGCCACUGCAGCCUUUCUCGGGGAAGAUGACACAUCUGAACUGAGGUACCCUCCAAAGCCUGUUCCGUAAAAUCAGCAAACAACUGACAGGAUAACUUCAGGAAGUGGGUAUUAAUUCUCACGGUAUAAGUGAAGACAUUAAGCACCAGAGUUUAAGUAGCUUGAUCCACUGAAAGAGAUUCAACUGUGUGGAACCUAUGCCGUGGAGAAUUGCUUUCUGCCAUUGUUAUCGUCCAGCAGUUGCCGAAUAGCUCUGACCUGAGCAAAGCAGUGAAACGCGGUGCUGUUGAGUGGGUUGCCACUGCACCUUUUUCAACUACUCUAGUCUUGUGGAGAAAAUACCCCUUCUAAAUUUUUUCUUCAUUGAAUACUCUCCCUCAGCUCCAGAGUACCAUAUAGAGUUUUCUUGUAUUUUAGAGUUACUGUUUUAUCAAAGUUUACCAGUCUUUUGUAUUACAUUUCUCCUGUCUAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications