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Homo sapiens (human) LY6E divergent transcript (LY6E-DT) URS000075CA9F_9606

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LY6E-DT: LY6E-DT is a long non-coding RNA (lncRNA) that has been found to be positively correlated with the expressions of 10 hub interferon-stimulated genes (ISGs) [PMC9365928]. It is located adjacent to the ISG LY6E, which has been considered a biomarker for systemic lupus erythematosus (SLE) diagnosis [PMC9365928]. LY6E-DT, along with NRIR and FAM225A, are special lncRNAs that can be induced by IFN-α stimulation and are closely related to the Type I interferon pathway [PMC9365928]. LY6E-DT has been found to be down-regulated in hepatocellular carcinoma and high-grade serous ovarian cancer [PMC9365928]. Among the six lncRNAs upregulated in SLE patients' peripheral blood mononuclear cells, NRIR, FAM225A, and LY6E-DT were positively correlated with a subset of ISGs [PMC9365928]. The mechanism of LY6E-DT is not well understood, but its proximity to LY6E may provide insights into its potential functions [PMC9365928]. LY6E-DT is one of eight lncRNAs that can independently predict the survival status of patients with clear cell renal cell carcinoma (ccRCC) [PMC9087998]. It is also included in a set of eight ubiquitination-related lncRNAs associated with ccRCC prognosis [PMC9087998]. LY6E-DT has been identified as one of 60 genes showing putative causal associations with spontaneous bacterial peritonitis (SBP) [PMC9686236]. In terms of gene expression regulation, there is evidence suggesting that IFN-inducible genes such as MX2, IFITM1, EPST1, MX1, and LY6E-DT are genetically regulated in a disease-specific manner [PMC8640069].

Genome locations

Gene Ontology annotations

Sequence

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GGCUCCUUGGGAUAGAUGGGGAAGCUGAGGCCCAGAAGGGGGCUGAGACCACCUCCCAGUUUCCCCAGUGAGGUGGCGCCUGAGCCACGGCCAGGCCCGGCCUCCUUCCACCCGGCCCUGCUGUGCGCGCGGCGGGUGCUGACCUGGCGAGGCCGGACAGGGGACCAGGUCGGGGUGACCGUCACUGACACCUGGACAGUCCUCGUUGUGUUCGGGGUGGGAAGCCCACGGGGAAGAGUGUAUCACAGCCAUUGGGAACUUUCUUCACCCAUCAAAGCCUCAGGGCUGAAGCAUCCUGAACAAGAACUCAGGAGAGUGAAAGAAACAGUUACCUGUCGGCUGCAGCUGGUACCAGCUCCCCACCCCGUACAGAGACCGAAGCGUCCUCUCUCUCCCCAUCACCCAGCACCAGACUCUGCCCCGCGACCUCAGCCUGCACCUGCUUCCUGGCUCCAUCCAGCCUUCCAGCCUCACUAGAUCAUCAUGGGCCACUGGCCAACACACAGGGCAGUGCCGAGCCCAGGCCGUGGUCACACAUGGCUGGGUUAGUAGCUGAAAACAUUGUUUUUCACUGGCCUCACAGUAAUGGCACCUGCCCCCAUUUUCUGUGAUUGAAUUUUUGGAUCCUGCUACCAGGUUAUGAUAGAUUUUAUGGUAUGUCUCAAGAUAUUGAGAUAAAGGUAAUAAAACAGCUAUAAAGUCAAAAAAA

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