v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) long intergenic non-protein coding RNA 1311 (LINC01311) URS000075C74D_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

LINC01311: LINC01311 has been found to preferentially bind with miR-146b-5p and its overexpression leads to a decrease in the proliferative potential of TC cell lines [PMC9685481]. Overexpression of LINC01311 also induces apoptosis in TC cells by increasing the relative protein levels of Bax and decreasing the levels of Bcl-2 [PMC9685481]. The functionality of the LINC01311-miR-146b-5p interaction was further investigated, and it was found that overexpression of LINC01311 promotes apoptosis in TC cells [PMC9685481]. LINC01311 acts as a ceRNA by sponging miR-146b-5p, suppressing its expression, and inhibiting the progression of TC [PMC9685481]. Ectopic expression of LINC01311 reduces the proliferative and migratory potentials of TC cells in vitro and triggers apoptosis [PMC9685481]. The ceRNA activity of LINC01311 to miR-146a-5p in Alzheimer's disease has not been described [PMC9685481]. In vivo studies using a mouse xenograft tumor model showed that LINC01311 overexpression impedes tumor growth by reducing tumor size, volume, and weight [PMC9685481]. The expression levels of LINC01311 are downregulated in TC cells and tissues, while miR-146b-5p expression is enhanced [PMC9685481]. Overall, LINC01311 is an anti-oncogenic lncRNA that suppresses the malignant behavior of TC cells both in vitro and in vivo [PMC9685481].

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
GUCGCCCCCACAGCCUGUGGGCUACGGGAACGCGAUCCGACUCGGCGGCCCUCCCUGCCUGGAUGGCCGGUCCCCGAGGCUGAGGAAGUCCAUUCCUCUUUCGGAAAUGGUCCCCAGGAAGCUUCUCCGUGUCCCCCUAUGGCCGGGUACUGAGCGGGGCCCGGGUGGUCUGCGGCCGUGGCCCCCGCCCCUCAGCGCAGGCGACCCUCCUGGCCCUGGCGGGCACAGCGCCUCUCCCGUGACCUGGGCCGGCCCGCAGGAUGAGCCCCCGGAUCACGAUCGCUGGCAUUUUAUUUACCUUCUUCCAUUACAACCCCAGGCGAGUCUCCCGGGCCCCGAGAGGAGGGGGUGACUGGUCAGGGUCAUCGGUAGCGGCGGCAGGGGCCUGCAUAGGGCUGCCUCGGGGCGACUAGCAGAAUGGCCGCCAGCCUCGGCUGCCCCAGCCCCCAGCGCAUGGAAUGUGCCCCGGGCCCCAGGAGCUCCAGGAACCGCGCUUGUGAGACGGAGCUUCGGCUGCUUGGAGCUAGUGAGCCACCGGCCACGGCAGGGAUUUGAGCAGAACUUGGGGGCAGAGGGAUGAGAUGGUGCAUCCCUUGAGGUCACUUCAGGAGAUGACACUCCUGUGGCUAAGUGUAGCUUCCCAGGUCAUGGCUCCCAGGUCAGGCCUGGUCAAUGGAGAAUUAAGUGGGCGUUGGGUGGUGGAUGGAUGUGAUUUGGCAGAGGGGACAAAUGUGACAACAGUGUAAUAAGGGCCAUGUUGGGGAGGGUCAGGGGUCAGGGUCCGGCCCAACCUGAGCAGAAGGGAGGCUGCUCUCAGGGAUAUUUGUCAGGUAGGAAUGGGUGGAGUGGAACUACAGGGCCACCAUGUUUCCCAUGGGUCACCCAUGGUGGCCUUGUCAUGUUUAUCCGUGAUCCUCAGUGUUCUCUGUGGUCCUCCCGUCACCCCUUUCAGACUGUCCUUUCAGUUCUCCACUGUCCCUGCAUCACCUCUGCCCCUGUCCCGUUUGUCUGUGUUCAGUCCAUGUUCCCAGGUCUUGAGGUGGCCCCUGGUUCUAUGCCCCUUACCUAAGACCCUGUGCAGGGAAUCUGUGAAAACACAGAGGAAAUAAAAAGUGAGGAAAAUAGUAAAAAAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications