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Homo sapiens (human) long intergenic non-protein coding RNA 1231 (LINC01231) URS000075C6B3_9606

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LINC01231: LINC01231 is a long non-coding RNA (lncRNA) that has been identified as one of the nine ferroptosis-related lncRNAs used to develop a risk signature for predicting prognosis and immune response in liver hepatocellular carcinoma (LIHC) [PMC9843414]. The expression profiles of these lncRNAs, including LINC01231, were found to be highly expressed in the high-risk group [PMC8484522]. A nine-lncRNA expression risk score was calculated for each sample, including LINC01231, and was used to assess the risk level [PMC8484522]. The roles of LINC01231 in hepatocellular carcinoma (HCC) have not been previously reported, prompting further investigation into its effects on apoptosis and proliferation of HCC cells [PMC8484522]. Knocking down LINC01231 by siRNAs was found to improve cellular iron concentration and malondialdehyde (MDA) levels in HCC cells, indicating its anti-ferroptosis effects [PMC8484522]. Additionally, LINC01231 was identified as one of the nine lncRNAs associated with prognosis in HCC [PMC8484522]. Knocking down LINC01231 by siRNAs also promoted cell apoptosis and attenuated cell survival in HCC cells [PMC8484522]. Furthermore, time-dependent receiver operating characteristic (ROC) analyses showed that LINC01231 had an area under the curve (AUC) value of 0.870 for survival prediction in HCC patients [PMC8484522]. References: - PMC9843414 - PMC8484522

Genome locations

Gene Ontology annotations

Sequence

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CGAGACGCCCGGUGACUUCUGCUGGCACCUGCUGCCCUCGGCAUCACCUCCCUCAUCCCCCUGGAGGGCACGCUGGAAAGCUGCAACUCCCCACCCUCCGCACAGGAGCGCCCCGUAGACGCGCAGAUGGGCCCAGCCACCCAGCGGGGCGGCAGCCCUGAGCACACAAGUUUGGAGAGCGCGCGAGGCACCUGAAAGUGGUUGGGGUUUGGAAGCAAAAGGGUGACACCUGCUGUUCGCUGGGACCGCUCUGCGGGUGUGGGCGUCGGUUUGGAAACGUCCUUUGCCUGAGCUCUGCUUGAACCUGGGUGCCAGAGACUACCUGGGACAGCUCUACUGACAUCAUCAGCACGUGAUUCUAGCCUCAUUAACUCUAACUUGGGAAAAGUGCUUCUGGAGGAAAGGGAAGAGAUUCUAAGGCUGUGUGCCCCAUUCUUAUUACUCUAUCUCAGUGGGUCUCAAUCCCGGCUACACAUUGGAAUCACUUGGAAAGCUUUAAAAAUAAAACCAAACCUGUGCUUGGGCUCCACCAUAGGUGUUCACCACAGCUGUCAGUAUAAAUCAAUGCAUCUUGGUUCCAUUCUUCAUCAUUUGCUGGUAGCUAAAUUAUGGUAAAUUCAGCUAAGGACAUUUUAAAAUCCUGUUUAAUUUGUCCACAUGCUAAAUAUCCCAGCACACAAGAGAAAAAGCAGCAUGUACUUGGAUAAGACAAACCUAGGGCUUCCUUCGAGUUAAGGAACAGUCUUGGAAGUCUUGUUAUAGUUAAUGGUUUUUUGAGUGGAUGAGCAAAUGAAUGAAUAUACAAAUGGUUAUGCACACAAUUAAGCAAACUACUUGAUCACAUUCCUCCUUUUGGUUUUGCUUCCUCUACCUGUCAGUUGUCCUGAACACCUGCGGAGGUAUUUUGUGCAGGAUGGUUUACCACAUUGGCCUUGGGAGUUGAGGAAGCACCAGCUUAGGUUCUGCCACGUGCUCUUUCCUGACAGCGAGUGCUGCUGGCUGCUGACGCCUAGAAUCUCAGCACGGGAGCUGCCUUUGUCACAGACCUUGGUUCCCCAUUCAAUCGAGCACCUGUGCAGUUGCCCUGUGGUCUAGCAUCCCAGGCUCAGCAGUGACAGCUCCUGAUGGGCUUUCACCUGACUUUCUAAAUCAGUGCUGUUCUAAAUCUGUGCUAAAUCUGGUGACCAGCCAGAGCCUGGUCACCCCUGCAUGGAGUAGGAGUGAAGCUUAUGAAAAGGUGAGGUGCCAAACACACAGAGGAGAACACGGAGGAGGCCAUAUUGUAAUAAAGAGAAAGCAAGCAGUCAGAAGUCACCCCAUAAAACACCUUCCACCCUCUGAGCAUGACCAGCAAAGCGGUUUCUUCUUGCGGACACUGCAUCAGCCCAGCUCAAAGUGCAUUCCAUUCUGAUGAACAUCCACAAACAGUUAUGAAGAAGACCCAAAUGUCAUGAUUUUGUUCCUCUCAGAUAAUAAAAAUAUCAUGAUUCUGAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications