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Homo sapiens (human) microRNA hsa-mir-3908 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-3908 precursor URS000075C62E_9606

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hsa-mir-3908: Hsa-mir-3908 is a microRNA that has been implicated in various biological processes and diseases (1). It has been shown to play a role in immune escape by regulating programmed cell death-ligand 1 (27) and in inducing stemness in EBV-associated gastric cancers through sponging circ-LMP2a (28) [PMC9093110]. Hsa-mir-3908 is also one of the shared microRNAs between ACE2 and TMPRSS2 genes, which are important for the entry of SARS-CoV-2 into host cells [PMC9511898]. In a study on MCI-AD and AD-dementia patients, hsa-mir-3908 was one of the most abundant miRNAs detected in blood leukocytes, CSF, and serum samples [PMC7515963]. It was found to be downregulated in MCI-AD patients compared to controls [PMC7515963]. The expression levels of hsa-mir-5588-5p, hsa-mir-3658, hsa-mir-567, and hsa-mir-3908 were quantitatively analyzed using the 2^-ΔΔCt method [PMC7515963]. Among these miRNAs, only hsa-mir-567 was found to be highly expressed in all examined tissues [PMC7515963]. These findings suggest that hsa-mir-3908 may have important roles in immune regulation, cancer progression, and neurodegenerative diseases (1). Further research is needed to fully understand its functions and potential therapeutic implications (1).

Genome locations

Gene Ontology annotations

Sequence

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GCCUGAGCAAUGUAGGUAGACUGUUUCUAAAAAAAUAAAAAGUUAAAAAAAUUUAUGUUAACGUGUAAUGUGUUUACUAAUUUUUUUUUUUUUUUUUGGAGACAGAGUCUCCCUCUGUCGCCAGGC

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2D structure Publications