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Homo sapiens (human) ARHGAP5 antisense RNA 1 (head to head) (ARHGAP5-AS1) URS000075C624_9606

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ARHGAP5-AS1: ARHGAP5-AS1 is a long non-coding RNA (lncRNA) that has been shown to interact with the PY motif of the SMAD7 protein [PMC8505316]. This interaction suggests a potential role for ARHGAP5-AS1 in modulating SMAD7-mediated signaling pathways. Additionally, ARHGAP5-AS1 has been implicated in human cancer progression through its interaction with various microRNAs (miRNAs) [PMC6920212]. Specifically, miR-600, miRNA let-7g, and miR-33a have been identified as targets of ARHGAP5-AS1 and have been shown to influence cancer progression by targeting METTL3 [PMC6920212]. METTL3 is an RNA methyltransferase that plays a role in regulating gene expression and has been implicated in various cellular processes, including cancer development and progression. The interaction between ARHGAP5-AS1 and these miRNAs suggests a potential regulatory mechanism by which ARHGAP5-AS1 can modulate METTL3 expression and subsequently impact cancer progression. Further investigation into the functional significance of these interactions may provide insights into the underlying mechanisms of cancer development and potentially identify novel therapeutic targets for intervention [PMC6920212].

Genome locations

Gene Ontology annotations

Sequence

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UCUCCCACCAUUGGUUCCCUCCCCUACUCCAUUCCUUCUCACCUUUUCCCUUUUACCCAUUGGCGUGAGUAUUUUUCCUCAGCUUCCCUCUUUCUCCGUAUUCUGCUCCUCCUCAGUCCCAUCCUCCACGCUUUGGAAGCUACUGCCUUACUGCCCGGAGCGCCGUCGUCCCCGAACCUCCCCUGCUUCUCCCUUUCCUUCUGUUCCGGUUUCUGGUCGUAACUCAAGAGCAAACCACCGUACUGCAAAGGAACCAGAUAUUGUGCUCGCGGUUCCAAACCGGGCAUGGGCACCGAAUGCUUCUCGAUAAAUCCCCUUAUGGUCUCUGAGCAUUAAAGAAAGCAAGGGAGGAAAACAUGCGCCCAAGCUCGUUCGCAGGAACAUGUUCGCGUGUCUGCGCCUGUGUGCGCAGCCAGUUUUCUGGCUGAGGAUCGCUCGCCAACUACAGACAUCACCCGCCCAGGACCCGGUGCCACACUCACCCAGAAGACGAAACUCCACAGGAGCGAGAAGAGGAGUCCAUUUCUCCGUCGGCUCGGCACGGCACGGGGAUGCAGGCCCCUGAUUCAGUACGUUCUGUGAAAGUGGAGCGAGAAGCCAAGACGUGGAUCGAGAAGCCCCGUGGGGCGGGUCUCAGGGUGGCCCAAAAGACCCCUGUUCACGCCACUACCAGCCUAACUUUAGGAACUGUCGUCCACCUGGCUUUUAUUAUACUGCCUUAAACAUAUUCACUUUUUUGAGACUCUAGAAAUUUCACAAGUUUUGGGGUAGAGCACACUGGGCUUUGGGUGUGUUUCUCAUGAGGGCACUGACGCUGAAUGGUGCAGUGAGAAAGGACGGUAGAAACCACUGCCUUUGCUUUUACCAUUGAAGAAACUGAGGUCCUGUGACUUUCCCGAGGUCAUCGGAAUCUGCCUUGCACAGGAGACUUAAAAUAGUUGCCAGCAGAUAAAAGAAUGAGCAAAACCACAUCUACUCCAAUUUGUUAAGUCUGAAAGAAAGUAAUUGAGGGGGGAUUCCUCUUUGGGGAAAUAUUUAUUUCCUGCAUUGAAAAUAGUUUAAUGUUAGUAAACAUAUAAAAAGUAUUUUAAAUUCAAGUUAUUCUUUAUUUCUUAUGUUACAUAAGGUACUGAAGUUAGCCAAGGUUGCUUUUGUGUUAUAAUGAUGCAGCUGCUGCCAACCAGAAGUACAUUUACGGUCUGUCAGUAAAGAAAACAAAAACUGCCUGUUGGUAAAAAUCUAUUAGAAAAUAUUUGUCAGUAAAUUUGUCACAAUAUUCCA

Taxonomic tree

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Publications