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Homo sapiens (human) RHPN1 antisense RNA 1 (head to head) (RHPN1-AS1) URS000075C57E_9606

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RHPN1-AS1: RHPN1-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including glioma, ovarian cancer, uveal melanoma, non-small-cell lung cancer, and ocular melanoma. It has been shown to have a carcinogenic role in glioma and is associated with disease progression [PMC7400277]. In ovarian tumorigenesis, silencing RHPN1-AS1 has been found to suppress tumor growth [PMC8810118]. RHPN1-AS1 has also been shown to reduce cell apoptosis and enhance cell proliferation, viability, adhesion, and migration in ovarian cancer cells [PMC8424490]. In glioma, RHPN1-AS1 affects tumor progression by targeting miR-625-5p/REG3A [PMC6769163]. It has also been found to be overexpressed in uveal melanoma and non-small-cell lung cancer [PMC7773464]. In oral squamous cell carcinoma cells (Cal-27 and Tca8113), knockdown of RHPN1-AS1 resulted in decreased expression of β-catenin, claudin-1, and vimentin which are critical for epithelial-mesenchymal transition (EMT) [PMC6692605]. METTL3-mediated m6A modification of RHPN1-AS1 contributes to its up-regulation in ovarian cancer [PMC9652818]. The effect of RHPN1-AS on ovarian cancer progression is dependent on TPX2 [PMC8082340]. Silencing RHPN1-AS impaired migration in uveal melanoma cells (OCM 11 and OM431) as well as SKOV3 and OVCAR3 cells from ovarian carcinoma [PMC5297855]

Genome locations

Gene Ontology annotations

Sequence

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GUUGUACUGCGCAUGCGCCGCGGCGGCCGCUGAGCGUGCGGGAGAAGUUCGGGAAACGGAGAAAAAAACUAUACGGAACGUCCCAAGCUGAGAGUCAGGGCGGACCUGGACUCGGCGCGCCUAGCUCCUCGGCUCCCUUUGCGGGGACUCCAGGAGUCUGCCCGCUCGCGCCGUUUCGUCCUGUCACCCCGGCAACGGGACCCUCUAAGAGGCUUGUUCCAAAAAUGUUCACAAUGGGGUUUUUAAAAACGGUUUUGUUAGGGACAAGUGCUUGUGUGAGUCCUCCGACAAUGCCUGCUUUCUUCUCUCUGCCCGCGGAGCGGAGGCUCCAGGCCUGGCCCCAGUCCGAGGCGCCUCUGUCGGUGUCGUCCUGCUUCCAAAACCGGCCUCCAGAACCCGCCUCCUUCCAGAACCUCCGUCCAGAACCCGCCUCCCUCCAGAACCUCCGUACAGAACCCACAUCCUUCUAGCACCUGCCUCUGGAACCCACGUGCUUUCAGAACUACCUGUUUGUAGAACUUGUUUCCAGAACGAACCUGCUUUCCGAAUCUCUUUACUUCCAGAGCUUGUUUCCUGGACUGACCUAUUUUCAGAACCUACUUUCAAAACCAGCUUGCCUCCAGGACCACCUGCUUGGAGAACUGGCCUGCAGCCCCAGGACUGGACGACCUGAGACUGCACAGCUCCCUGCGGGGCUCACCCGGCUGUGUGUGUCCUUCCGGGCCUUCCAUACUUCCCUAGGUGUCUGGUGACUCCGGAGCCCGCUCGGAUUUCGUGUGGGUCUCGCCUCAGCUCAGAACACACCCUUUGAAGAGCAGGAAGGCCAGGGCACAGGCGGUAACCACGGCUCCUGGUCAUCAAGUUCCUCUGAAGCCCAGGUCUUGUCCACGUUCACUGCCCCACCACAGGCCCAGCGGAGCCUUGGAGCUGAGCCCUGGGAUCAUUCUGGUGCCUGUGCUCCCGGCUCCGCAACAAGCACACAGGAGCCUGUCAUCCCCAGAUCUAAAUCCUGAAGGCUAAGCUCCGUGGUCUGCCGCAGCCAUCUGCAGCAGGCCCCUCCCAGCAACAGCCUUCUCAUAAGGCCCCUGCCAGCCACGCGAAACCUCCUGGCUAGGGCCUGUCUUCCACUCCUGGCCUUUUGAGACAGGGCCUCACUCUGUUCCCCAGGCCGGAGUGCAGUGGUACGAUCACAGCUCACUGCAGCCUCCACCUCCUGGGCUCAUGUGAUCCUCCCACCUCAGCCUCCUGAAUAGCUGGGACUACAGGCUUGCACCACCACACCCGGCUAAUUUUUGUAUAUUUUGUAGAGACAGGGUUUCGCCACAUUGCCCAGGCCCAGGCUGGUCUCAAACUUCUGGGCUCAAGCAAUUCAUCUGCCUCAACCUCCCAAAAGUGCUGGAUUACAGGGAUGAGCCACCAUACCCGGCUUUUUUUUUUCUUUCUCCUGGCCUUUUGGGGCCCUUGAAGUGUCUGCUCCCUGGGAGCCCUUCAGCUUGUCGUCCACUUGGUGGGUUCCCACCCGUCCUUCUCACUUCUGCCUGAAUCACACAGGCUACAUGAGACCUUCACCCACCCCCUUCGCCAGCAGCUCUGUGGUUCAAGUUUCCUCAAGGUUAGGGGCUCCUGGCCAUCUUACCUGUGGGCCUGAGCAUGGGCCGAUGCUUCCAAAGUUCACACUGGGUGCACUUGUGUGGGGACUUCCAUGUGAGUCAUCUCCUUGCAGGCUGCCAAGGUCCUGUACAGCAGAGACCCAAACCCUCUUAGCAGUCUUCAGAGUCAGCUAUGUGUACAGGAGGCAUUACCAUAUCAGUGACUGUCAGCAAGCAUGUGUGACUGAAAUGGUAUCCAGUUCUUACGUAUUUGUUUUGCAGGCUUCUUGGUUCAGCAGACAGAGGCCAUUGGGAAGUUAAGAGAGGCUCUCAAACUUUGAGGGUCAUAAGACUUCCCCUCCCUGCAGGGUGCUGUUUCCUGAAGGAAAAUAUUCAAUUACUAUUUUCUUUAUUUAUUUAUUGAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications