MIR4300: MIR4300 is a microRNA that has been implicated in the progression of adolescent idiopathic scoliosis (AIS) [PMC8117547]. Studies have shown that the down-regulation of MIR4300, possibly caused by the allele G of rs35333564, may contribute to the risk of curve progression in AIS patients [PMC8117547]. The association between genetic variants of MIR4300 and curve progression has been validated in a large population [PMC8117547]. The target gene of MIR4300 that may be involved in curve progression is suggested to be CRTC1 [PMC8117547]. However, further studies are needed to evaluate MIR4300 expression in other AIS-related tissues and to confirm its functional role [PMC8117547]. The expression level of MIR4300 has been found to be significantly correlated with curve severity in AIS patients [PMC8117547]. Through gene expression analysis, CRTC1 has been identified as a potential target gene of MIR4300 that is inversely correlated with its expression level and curve severity [PMC8117547]. Patients with genotype GG of rs35333564 have shown significantly lower tissue expression of MIR4300 compared to those with genotype AA [PMC8117547]. However, the function and role of MIR4300 are still unknown and require further investigation [PMC7062733][PMC9180299][PMC7537684][PMC5492892][PM9695868].