hsa-mir-302f: Hsa-mir-302f is a transgenic human exomiR that is released from adipocytes and can affect gene expression in the liver [PMC9464960]. It has been observed that hsa-mir-302f can repress the luminescent signal from hepatocytes in mice that express a 3′UTR reporter specific for hsa-mir-302f [PMC9464960]. The expression of hsa-mir-302f was induced in the brown adipose tissue (BAT) of mice to investigate if adipose-derived miRNAs can travel to the liver [PMC5539684]. To validate this, hsa-mir-302f was expressed in the BAT of one mouse and a reporter was expressed in the liver of another mouse, and exosomes containing hsa-mir-302f were injected into the mouse with the reporter [PMC5539684]. The use of human-specific miRNA (hsa-mir-302f) ensured that it did not have a mouse homolog [PMC5539684]. The activity of the reporter in the liver indicated if hsa-miR from BAT had traveled to the liver, as mice liver does not naturally have human hsa-mir-302f [PMC5539684]. The pre-miRNA secondary structure of miRNA hsa-mir-302f has been determined using an algorithm developed by Mathews et al. [PMC6397858]. Hsa-mir-302f is associated with seven diseases, including head and neck neoplasms, breast neoplasms, and gastric neoplasms [PMC7820843]. Adenoviral delivery of hsa-miR-302f to BAT resulted in suppression of a miR-302f 3′ UTR reporter in liver [PMC5572399].

MIR302F: MIR302F is a microRNA that has been associated with crystal-induced inflammation, which is the final stage of gout development [PMC9333104]. It has been found to be down-regulated in gout patients [PMC8553949]. In a genome-wide association study (GWAS) comparing gout patients to individuals with asymptomatic hyperuricemia (AHUA), the MIR302F locus was identified as one of the risk loci for gout [PMC6788923]. Additionally, an intergenic SNP near MIR302F, rs9952962, was found to be associated with gout in a meta-analysis of three stages [PMC6788923]. Furthermore, MIR302F is located on chromosome 18q12.1, which has been associated with Alzheimer's disease in previous GWAS studies [PMC6330399]. References: - [PMC9333104]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333104/ - [PMC8553949]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553949/ - [PMC6788923]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788923/ - [PMC6330399]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330399/