hsa-mir-4261: Hsa-mir-4261 is a microRNA that can target the REL gene, and it is one of the 153 miRNAs that can target REL [PMC7854084]. Hsa-mir-4261, along with hsa-miR-6836-3p, has been identified as a potential anti-cancer therapeutic due to its relevance to multidrug resistance caused by ABC family activity or MGMT proteins [PMC7404280]. Additionally, hsa-mir-4261 has been selected as a potential anti-cancer therapeutic for regulating the DNA repair protein MGMT [PMC7005303]. Hsa-mir-4261 is one of the miRNAs that include hsa-miR-370, hsa-miR-491-5p, hsa-miR-6836-3p, and others that have been identified as potential therapeutics for regulating MGMT mRNA [PMC7005303]. In a study investigating miRNAs with high Target scores, hsa-mir-4261 was further examined [PMC7005303]. Using specific filtering criteria for ABCB1 and MGMT mRNA regulation, three miRNAs were identified as potential therapeutics: hsa-miR-370, hsa-mir-4261, and hsa-miR6836 [PMC7005303].