HNF4A-AS1: HNF4A-AS1 is a long non-coding RNA (lncRNA) that is downregulated in late-stage samples compared to early-stage samples [PMC6914412]. In a study, the expression levels of lncRNAs C3P1, DIO3OS, and HNF4A-AS1 were found to be low in late-stage samples [PMC6914412]. Biotin-labeled RNA probes were used to study HNF4A-AS1 truncations in vitro [PMC7098112]. HNF4A-AS1 is a lncRNA that has been implicated in various biological processes and diseases. It has been found to be downregulated in late-stage samples, suggesting its potential role as a biomarker for disease progression [PMC6914412]. In the study mentioned, the expression levels of C3P1, DIO3OS, and HNF4A-AS1 were compared between early-stage and late-stage samples. The results showed that these lncRNAs were low expressed in late-stage samples [PMC6914412]. To further investigate the functional role of HNF4A-AS1, researchers used biotin-labeled RNA probes for its truncations. This technique allowed them to study specific regions or fragments of HNF4A-AS1 in vitro [PMC7098112]. The use of biotin-labeled RNA probes provides a valuable tool for studying the structure and function of lncRNAs like HNF4A-AS1. In conclusion, HNF4A-AS1 is a downregulated lncRNA that shows differential expression between early-stage and late-stage samples. Further studies using biotin-labeled RNA probes have been conducted to investigate its functional role and potential mechanisms of action [PMC6914412] [PMC7098112].