MIR620: MIR620 is a microRNA that has been found to be inversely correlated with the degree of hepatocellular carcinoma (HCC) differentiation [PMC3575633]. In a GWAS study on DISC1, MIR620 was identified as one of the genes associated with psychosis proneness, predominantly linking to the DISC1 pathway [PMC4872463]. RT-qPCR analysis using TaqMan microRNA assays revealed the presence of MIR620 in the brain, suggesting its potential role in mental illnesses through dysregulation of genes involved in brain functioning [PMC7000740]. In silico analysis further supported this, showing that molecules predicted to be targets of MIR620 are enriched for genes implicated in bipolar disorder and nervous system development [PMC3281861]. Additionally, LCT is one of the predicted target molecules of MIR620 [PMC3281861]. The loci for these target molecules are found on chromosomes 2q21.3 (LCT), 2q31.2 (CCDC141, TTN), 4q13.3 (CXCL3), 10q23.1 (KIAA1128), 12q24.21 (MED13L, MIR620), and 16q22.1 (TMCO7) [PMC3281861]. Overall, these findings suggest that MIR620 may play a significant role in HCC differentiation and mental illnesses through its dysregulation of various genes involved in brain functioning and bipolar disorder development. References: - [PMC3575633]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575633/ - [PMC4872463]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872463/ - [PMC7000740]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000740/ - [PMC3281861]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281861/