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hsa-mir-3937: Hsa-mir-3937 is a microRNA that has been found to be upregulated in colorectal cancer (CRC) patients compared to healthy individuals [PMC9117024]. It has been shown to bind to and downregulate the expression of the BCL2L12 gene [PMC9117024]. The expression levels of hsa-mir-3937 in CRC patients were found to be significantly increased [PMC9117024]. Exosomal hsa-mir-3937 has been identified as a potential diagnostic marker for CRC [PMC9117024]. It was found that the combination of hsa-mir-3937 with CEA and CA199 had a higher area under the curve (AUC) compared to other combinations, indicating its potential as a diagnostic biomarker for CRC [PMC9117024]. The expression levels of exosomal hsa-mir-3937 were associated with T stage, indicating its potential as a prognostic marker for CRC [PMC9117024]. Silencing hsa-mir-3937 resulted in decreased invasion and migration of CRC cells, suggesting its role in promoting tumor progression [PMC9117024]. The binding site of hsa-mir-3937 on the BCL2L12 gene was predicted using TargetScan [PMC9117024]. Exosomal hsa-mir-3937 expression levels were higher in advanced stage CRC patients' plasma samples compared to early stage patients' plasma samples [PMC9117024].
Reference:
[PMC7933252]
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