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hsa-mir-4267: Hsa-mir-4267 is a microRNA that is upregulated and potentially involved in the suppression of target genes [PMC9781133]. It is also associated with gliogenesis [PMC9781133]. Although there is no experimental evidence of its functions, hsa-mir-4267 has a predicted seed sequence in a specific region [PMC5613348]. Hsa-mir-4267 has been found to target genes such as DNAH3 and GOLGB1, and it is one of the miRNAs with higher context++ scores compared to others [PMC7766228] [PMC7249963]. It has also been identified as one of the potential targets of ELMO1-AS1, along with hsa-miR-5096 and hsa-miR-4691-5p [PMC6689543]. In the context of hepatocellular carcinoma (HCC) development, hsa-mir-4267 is co-expressed with several other miRNAs, suggesting its involvement in HCC progression [PMC9820840]. In terms of evolutionary analysis, hsa-mir-4267 shows mismatches in the chimpanzee lineage, indicating potential evolutionary changes in this microRNA sequence [PMC4966751].
References:
[PMC9781133] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781133/
[PMC5613348] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613348/
[PMC7766228] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766228/
[PMC7249963] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249963/
[PCM6689543] - https://www.ncbi.nlm.nih.gov/pmc/articles/PCM6689543/
[PCM9820840] - https://www.ncbi.nlm.nih.gov/pmc/articles/PCM9820840/
[PCM4966751] - https://www.ncbi.nlm.nih.gov/pmc/articles/PCM4966751/
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