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Homo sapiens (human) loss of heterozygosity on chromosome 12, region 2 (LOH12CR2) URS000075BAC1_9606

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LOH12CR2: LOH12CR2 is a long non-coding RNA (lncRNA) that has been studied in various types of cancer, including cervical cancer, gastric cancer, and gastric carcinoma [PMC8457683, PMC6691204, PMC6456668, PMC8758778]. In cervical cancer, LOH12CR2 was found to have a negative coefficient in a prognostic signature, indicating that its downregulation was associated with a lower risk of recurrence [PMC6456668]. In gastric cancer tissues, LOH12CR2 was downregulated compared to adjacent normal tissues [PMC6691204]. LOH12CR2 was also found to be differentially expressed between tumor tissues and normal tissues in various types of cancers [PMC9691877]. The expression levels of LOH12CR2 were lower in tumor tissues compared to normal tissues in gastric carcinoma [PMC9691877]. Additionally, LOH12CR2 was expressed at higher levels in normal tissues than in cancer tissues in gastric carcinoma and luminal A breast cancer [PMC9691877]. The role of LOH12CR2 in the development and progression of these cancers is not fully understood but it has been suggested that it may have crucial roles based on its expression patterns and association with prognosis-related factors [PMC9691877].

Genome locations

Gene Ontology annotations

Sequence

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GGCUACGCAAGACCUUCAGUUCCGGAUUAGGAGGCCCCGCCCCCCGGCCCGAGGGAGGGGCGGAGAGACCCGCUCCUGCGACUUAGGGCGAUGCCACCUUAAAGGGCUUGACCUCCUCGAAGCCAGAACUGCGGAAGAGGAUGGAGAAAGAAACGCUAGAUAGACCCAGGAUUCGAACCCACAACAGCUUGGAUGCAAAGCUCAUUUUGAAUUCUGAAGAGCUGGGAGUUUAGCAGUGGACGACCAAACAAAAAAAUACCAGAAGACGGUGAAAGCAGCAGCUGGAAAUGAGAGAAAAAUUAAGAAAUAGAAAAUGCUGUUUCAUGUAUUAGGGAGUGCACAUCUUUAAAGAGAAGUGAAGAACCUUUUUGGCUAGGCGCUUUCUGGGGACCUUGGCAGUUAUCAACAAGUCACUCUGAAACUAACAGAAGGUGAGGAGGGAGUAAUCCAGAAAGGAAACUGCCAUUUUUGCUAGGGCAAGAAAGUAGACCUAGCAAUGCAAUGCCAUCAAGGAGUUAGCUGGCUCUAGCGUUCUCCGAACUUUGCAACUCAUUUUAUAUUACAUUGUCUGCGUCAAGAAAUUUCAAGUAAAUGCCUUGAGAUUUUAUAUGUAUAAAAUGUAGUCUCUGGCCAGGCGGGGUGGCUCACGCCUGUAAUCCCAGCACUUUGGGAGGCUGAGGCGAGUAGAUCACGAUGUCAGGAGAUCAAGACCAUCCUGGCUAACAUGGUGAAACCCCGUCUCUACUAAAAAAUACAAAAAAUUAGCCGGGCAUGAUGGUGGGCGCCUGUAGUCCCAGCUACUCGGGAGGCUGAGACAGGAGAAUGGUGUGAACCCGGGAGGCAGAGCUUGCAGUGAGCCGAGAUCGCGCCACUGCACUCCAGCCUGGGCGACAGAGCGAGACUCCGUCUCAAAAAAAAAAAAAAAAAAAAAAGUCUCAGAAGAAGUGUCAAGUUGACUAAAUGAUUUUUAAGUCCCUUCCACUCUACUAUAUCACAAUAAUUUCCCCUAUUUUACCUUAUUUAAUUUUCACAACAACCCUGCAGCCUGUAAGUAGGUGACUCCUCCAUGGUCAGCAGGUGGUCAGUGGUCGAACUAUUUAGGACUAUCUGAUGCUCUUUCCUCUGCUCACCAUUGCAAUACAAUGAGAAAAAUGCAAAUGAAUCUAAGUACAGUGUUCUCUGGGAAUAUGAAGAUAGAACUAAAAACUGCCUGAGAGAUCAGGGCAGGCUUCUAGAAAGUUGUGUCUAACUAGUCUUGAGGUUUACAUAAACCACACCAGGCUGAUGGGACUGGGAAGGGCCCACUAAGCAGUGAGACCAUUCCCUUUUGGAGAGUCCUUGCAUCCCCUCCCAGAUUUCCUCUUUGAGGGGAAGGUGAGAGAGGAGGUAAAAGGGGUGAGGAAUGGAGAAUAACUCAUUCUGGUUCUUGUUUCCCCUUUUCCACAUAAAAGUAUAUUUGUCUUGUGUUCCAUACACCAGUCCAUACUGAUGUGAUGGUGUUUUUUAUGCUUCCUUUUGAAUAAACAUUUCAUUCUUAA

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Publications