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Homo sapiens (human) HLA complex group 14 (HCG14) URS000075B70A_9606

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HCG14: HCG14 is a long non-coding RNA (lncRNA) that has been found to be differentially expressed in various diseases, including preeclampsia, pancreatic cancer, and celiac disease (CeD) [PMC5693921] [PMC7673061] [PMC8413039]. It is one of the seven lncRNAs that showed at least a twofold change in differential expression [PMC5693921]. HCG14 is poorly conserved across primate species and has been associated with decreased expression of the nucleotide binding oligomerization domain containing 1 (NOD1) gene in duodenal intestinal cells [PMC5693921] [PMC8608538]. In pancreatic cancer, HCG14 has been identified as one of the lncRNAs with significant prognostic value [PMC7673061]. In CeD, mutations in HCG14 have been found to change NOD1 expression in intestinal epithelial cells, contributing to the disease pathogenesis [PMC8413039]. However, the precise molecular mechanism underlying the role of HCG14 in these diseases remains unclear and requires further investigation [PMC8413039] [PMC8608538]. Overall, HCG14 appears to be involved in various disease processes and may have potential diagnostic and prognostic value.

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Gene Ontology annotations

Sequence

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GGCCUUAUAACUGUUAUCGCCAUCUCGAAAAACGUGUGCGGGUUUUUUUUUUUUUUUUUUUUGCUCCCAGCCUGCCCAGAUUUCAGGAAGGAAAGAAGAUCUUUUGCUUCUUCGGUCGCUGGGUCGGCUCUCCAGUGUCUGAUGUUUACUGAAAUCUUGAUCGUGGUUAGCCUCCCCCAGGACUUCAUUGUUUGGAAGAUGCCUUCGCCAAGCAAUCUGAGCUCCAGGCCGGGAAGCCCCAAGGUCACAAAUUUUAAUGGAGCCCUGAAACUAAACAGAAAUCAUCCCUCCCACUAGAACAAGAGCCCCUAGAGGCCAGCGACACCGCUAAAAUAACAUGUGUAGACCAAUGCCGUCCAGGUAACAGUGCCUGGCAAACACGGUAGAGGUUCAAUAAAUACAUUUUAACUC

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