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Homo sapiens (human) MORF4L2 antisense RNA 1 (MORF4L2-AS1) URS000075B67E_9606

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MORF4L2-AS1: MORF4L2-AS1 is a long non-coding RNA (lncRNA) that is part of a prognostic signature for esophageal squamous cell carcinoma (ESCC) patients [PMC7419219]. In the five-lncRNA survival prediction model, high expression levels of MORF4L2-AS1, AC007179.1, and RP4-735C1.6 were associated with shorter survival, indicating that these three lncRNAs are risk factors for ESCC patients [PMC7419219]. The lncRNA risk score was calculated based on the expression values of these three lncRNAs and two others [PMC7419219]. Patients with higher expression levels of AC007179.1, MORF4L2-AS1, and RP4-735C1.6 had a higher risk and more deaths [PMC7419219]. In addition to MORF4L2-AS1, other lincRNAs were identified as potential prognostic biomarkers for ESCC patients [PMC8939184]. These include RFPL1S, ADAMTS9-AS2, IBA57-AS1, and MYOSLID which were found to be up-regulated or down-regulated in ESCC patients [PMC8939184]. Furthermore, univariate Cox analysis identified 56 differentially expressed prognosis-associated lncRNAs in ESCC patients [PMC8883231]. These include ZNF674-AS1, LINC00973, KMT2E-AS1, TNFRSF10A-AS1, PDE2A-AS2 and many others [PMC8883231]. The expression levels of certain immune checkpoints such as CTLA-4 were found to be related to the expression levels of several necroptosis-related lncRNAs including TNFRSF10A-AS1, PDE2A-AS2, and LINC01679 [PMC8883231]. Similarly, the expression levels of PD-1 and PD-L1 were also found to be related to the expression levels of specific lncRNAs [PMC8883231].

Genome locations

Gene Ontology annotations

Sequence

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CCCCGAACACGGAAAAAAAAGGCGCAGUGGGGGUUCUGCUGUGUUUGCAAGUGAGGGUCGUGAGUGCAACGGGCGCAAGGCAUUAAGGCCAGUGUGUUAGUGCGCGGGCAGGCUCGCGUGGUGCUGGGGUUGCUGUGUGAGCGGCCCUCGUGGCUCGGGAGGUGCUGUGUUUGCGCAGGCGUGCGCCCCUGGCGUCGGGACUGGGACUCCGGAUUUCUGUGGCGACUGAGGCGCUCUUACCUUUGCGUCCUGAUCUCCAAGCAAGCACACUGACCUUCUUCAGGCAAAUACGCACUGUUAAUUUUCCAGAAAGUUCUGUGAGUAAGGUUUAUACCUCUCGAGUCUGCCACUAGAUGCCGCCAAAUCCCAGCAAAGGAUUGGCUGUUUGGUCCCUGGGAUUCUGGGAUUUUGUUUCCCUCCCCCCUCCCCUUUCUGAUUUGCUGAACGGUAAUAUCUAUAGGCAUCAUGGAUAUCGUUCAUUCCUAGGAAAAAAUAAAAUCAACUUCUGUAAAUAGCACUAGUAGGCAGGGGACUGUGACCCAAGAUCCAAAUAAUUUUGCUCAUUUCUUUCCUUUUCUCCUUGGGUUAAAAAAAAAAAAAGGCCCCUCUCCAUCCCUCUUUUCUUUUGUCCUUGCCUUGUUUAAUCAAAGAGUUAAUGAAUGACGCAAGCACUGAUGCUGAAGAUCCUAACCCUUUUUCCUCACCUUUUCAAAUGCUCGCAACUCACCCAAACUGAAAAUACAGAUAGCUGUUCCGUCAGUAAAGAUAGAUAAGAACUCAUCAGUAAAACCUGGACCCUGGUAUUGAAAACUGAUUUUCCUUUUCUCUUGAAAUUUGUAUCAGAUAUGUGUUUUUGCACCCUAUUUUCUGUAGUGGUAUUGGUAAACUUUAUUGUGUCUUUGGAGUAAGAGAAAGAGACCUAAUUGUAAACCUCAUUCCACCACUUACUAGUCUCAGUACCCUGGGCAAAUGAUUUAUGUUUUGUGAUCCUCAGUUUUUUUGUAUGCUUUCUAUAUUUUAGAUGCUGUGUUAUAUCGUUCACGUUGAUUUUUUUAUUCAUCACCAAGUCCUUAUUAGAUGAGCACUACUGGAUCAAAGUCAAACAACAAAAAUCAUACCCCUUUCAAUUAUCUAUCUUAUAUACUUGUACACCACACAGGAGGGAUUUUUUUAGAGCAGUGGUUCCCAAGGUGUGUUUCCUGGAUGUACCAGAAACAUCAGCGUCACCUGAAAAGUUGUCAGAAAUUCGGAUUCUCAGGUCCCACCUCAAACUUAAUGAAUCAGAAGUUCGCAGGGUGGGGUUUAGUAAUCUGUGUUAUUACAAACUAUCCCAGUGAUUCCAGCACACACUGAAGUUUGAGAGCCACUGCUUUGGAGAGUAGAAAUGCAAUGCAUAUUUUUGUACACACCACUAGAGGGUGCUACAGAAUGUAAAGCAAAAUAAUAAAUGAUGCACAGUAUAUGUUUUCAGACACCCUCUAUAUUAUCAGUCCUAUUUUACAGAUUAAAAACUAAUGUGUAGAUAUGUCAAAUUAUUUUCUUAGUGUACGCAACAAGUAUGGGAACCAGGAUUUGAACUUCACCUGCCUCUAGCCCAAGCCCCUAAUAGUACUCUGUUGUUUAACCAUGAUGACUUGUCUUUCCAAGCCUCAAAAUACAUUAGAAAUAUCUUGUUCCCUGCUUUGGCUAAUGUUGACUGGAGUGUCAAGAAGAGUGCAGGAAAGCAAACCAAGCUGUUGCAACCUCACCAGAACAGCUGAAGAAUGAAUUUCAGCCUGGACUCUACCUUAUUAGUUGGGCACCCUUGGGGAGGGUGCAACCUGCCCAACAUUUUCUGCUGGCCCUGUCUUACCUCAUGACUAAGAGAGCCUUCCUAGGUCUGGAAGGUAGCAGUCAGUCUGUUCUGGAGGGUGGAGAGAGACACCAGUGUUUUCCCAUGGUUUCUGGGUAGUAGAUAAAAUUGGUCUAUUCUAAGGUUAAUUUGAUAUUUUAAAAUUUUGAUUCUGACUAGCUUAUUGGAUUUUUUUGAAUAAUGUUUGAUUAAUGUAAAGGUUAAAAAUAAAACCUAAUAUUUCAGCUAAGCAAAUGGUAUUUCUUUAAUAAGGACGUAUUUCUAUCUAUUUAUACCUGCCUCAUUCCAUAGGAAUUUUAUAAAGCCAGUCCAGGAAUGUAGUCUGAAUCAAUCUAGUUUGCUAGCCUGUGAGACCAGGGCAAAGAUGAAAAUAGUCAUGGGAAAGUUUUAUCCUUUUAGGGGUAUCUGUCUUCUUCUAGUUCCUCUCUCCUCCUUUGACAAAUCCCCACCCCGAGACUGACCUACCCAUUUGACAGAAUGAGAUUACUUCUUCAAAUGACCCAAAACACUGAGAUCCUGAACCUAAUCAAUAAUGUCCUUGGAUGACCUUGGGAUGCCAGAUUCACACAUAAUUCCUUGUUGUCCCCUUCCUGAGUUAAUAGUUUAGCAUACAAUUUACCAAAAUUUGUAGUUUCCUGAGCCACAGACUUCACUUGGAAUGAUCAUAUAAAGUCAUCCAUGCUACAUACCAACCCACAGAAAUGAGGACCGCUUUCCUCCAGUGUAUGCUGAGUCCUACAAUCUGAGCACUGCUUCAAGAGGAUGCCUUGAGUCAUUUUUCCAGAGUUAAAUUUGCUUAUGCUUCUAACCUCCACCUACAGUCCCCGUUACACUGGGAAUGAUAAAAACUAUGCCUUUUGAAAAUAUAAGCUGUCAUGUUAUUAAAGAUGACAAACCAGUAGUAGUUAAAGUGCUGCAUCUAAAUUGUUGAAGCUUGUUACGUGGGAGUUCAUUAGACUGUUUUUCCUACUUUUGUGUAUUUUUGAAGUUUUCCAUAAUAAAACAUUUAAAAAGACAAAAAAAAAAA

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