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Homo sapiens (human) NR2F1 antisense RNA 1 (NR2F1-AS1) URS000075B396_9606

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NR2F1-AS1: NR2F1-AS1 is a long noncoding RNA (lncRNA) that is upregulated by the hypoxia inducible factor, promoting cell proliferation, migration, and invasion through the activation of the NR2F1/AKT/mTOR pathway [PMC9857713]. It has been observed that NR2F1-AS1 and NR2F1 respond to the epithelial-mesenchymal transition (EMT) signaling in gastric cancer cells [PMC8791943]. Additionally, NR2F1-AS1 has been found to affect cell cycle progression and proliferation in pancreatic ductal adenocarcinoma cells [PMC8505696]. It has also been shown that NR2F1-AS1 regulates VAMP7 expression by sponging miR-29a/b/c and miR-218 [PMC8791943]. In hepatocellular carcinoma (HCC), NR2F1-AS1 sponges miR-363 to release ATP binding cassette subfamily A member 1 (ABCA1), contributing to oxaliplatin resistance [PMC8508708]. Furthermore, the effects of three lncRNAs, including NR2F1-AS1, on glutamine metabolism-related genes have been observed in cancer cells [PMC9076293]. In thyroid cancer cells, NR2F1-AS promotes proliferation and migration while inhibiting apoptosis [PMC8810033]. Bioinformatics analysis has identified miR-642a as a potential target of NR2F1 in HCC [PMC8478570]. NR2F1's role in breast cancer (BC) was investigated through siRNA transfection experiments in MCF7 cells [PMC8786478]. It has also been found to play a role in esophageal squamous cell carcinoma and non-small cell lung cancer (NSCLC) progression [PMC7789809][PMC7993723]. In osteosarcoma cells, reduced expression of NR2F1 leads to decreased proliferation, migration, invasion in vitro as well as decreased tumor growth in vivo [PMC7993723]. NR2F1-AS1 expression in gastric cancer (GC) is downregulated in situ but increases with the invasive potential of GC cells [PMC8569557]. The expression level of NR2F1-AS1 in GC has been detected [PMC8294992]. The association between NR2F1-AS1 and its target genes has been investigated [PMC8810033].

Genome locations

Gene Ontology annotations

Sequence

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GGCGCGGAGCCGCGCGGAGUGACAAAGCCGCCGCUGCCGCCGCCGGGGGUGGGAGCCGCGCUCGCCCGCCCGCCCCUCGACUCGCGAGGGCGUAAAAGUUUGUCUCAGCUCGAGCAUUCCUAGCGCCAACACGCCCUCAGGUAAAGGUGGAAGUAAAUGGCCACGCUGUAUUGACAGAGCAGGUAGAUGAAACUCAAGAGAAAAGGUGUGGAUAAAUGAAACUAGCCCAUGAUGAACCUGUUUUCUCCGUGACCACAAUAUUAACCAGGAUGAAUGGCGGUGGCAGUGGGCCUGCAUCACAGGUUGCAGCAGAUGUUCUCAAUAUUUCUAUUAAAAUUUCCUUAUUUCCAUAUGCAAGAGGAGCCCCAGAGCUGCAUCCUUAUGGUAGCUACCAUGCCGUGAUGUAAGCUGCCAUUCACUGGGGAGCUUUGGCAAUAGAAUUGGCUAGAUCAGGAAGCCUAUGUCAACUAUGGAACAACAACUUGCAGCUCAUCUCUAUUGAUGAUGGAAUCUCGCUAUGUCACCAGGCUGGAGUGCAGUGGCGCAACCUCGGCUCAGCGCAACAUCCGCCUCCCGGGUUCAAGUGAUUCUCCUACCUCAGCCUCCUGAGUAGCUGGGAUUACAGGAAUCUAAUGACCAUUGAACUGUGGCCAUGACUUCAAUUACAAGUAUUUUCUUCACUAAUGUCAGACUGUGGGCCUUUGUAUAUACACUUUUAACAAACUUUUUGGAAGUGCAAUACAUAUCGCAACAACUUCUCAAUGCUGAAUCAUAGUAUUGGAAGACAUUUUAAGCAACAAUUAAACUCAACUUAUUUACUACCAAUAAUGUACAUAAGUCAGCUGAAGUGAGGAUAACAUGAAUAGCACAAAUACAUUAUGAUUGCUGCCUGGCCAACAGUAAUUAUAAGAAACUGUCAGUUUUGAGAUGUGUCUUGAUUUCAGAGAUGUUAAAAAAGUUUGUAAGUUACCAUUGAUAAAAUAUGAGUUUGCUUCCACAAAUAUUCUUUCUUCUGUCCUUCUGGAACUCAAGAGUAAACAUAUAUUAGAUUUUCUCACCAUUUCAUGCAUGCUGGUUCCUAGGCUACUCUCUGAGUCAUUUUUUUUUUCUUAUCUGCCCUCCAGUUCACUAGUUCUGUCAUUUUCUGGGUCUGAUCUGCUGCAAAUGCAAUACAUUGAGUUUUAAAUUUCAGUCAUUGUGUUUUCAUUUCUAGAAAUUUCAUUUGACUCUUUCUCAAAUUACUUUUCCAUUUUUUUUGUAGUUUCCUAUCCCUGGAGAUAUUUUCAAUCAUGCCAUUUAAUUUUUUAAAUACGCAAGUGUAGUUUUAUAAUUUGUGUCUGAUAAUUCUAAUAUCUGAAGUCUUAGUAGGUCUGUUUCAGUUGUCCUGUAAUUAUGCAUGUUUUUGCCCAUGUUGCUUUGUUUCCUUGUAUGCUUGGUUAUCUUUCUUACUGCCCUUGCAAAAUUAUUUGGAGAGUCCUGGAGGCUUAAAUGAAGAUAACUUUUAGGAAUAAUUUGCAUUUGCUUUUGCCGAGGAUCUUGGGAUCAUUUCAACCAAAAUCUUAGCUUGAAAUUCCGCAAUCAAUCAAGGUGAUGAGAACCUGGUCAGUAAAUCCUAAUGAGGGCCAGGCUGUGGCCAAAGAUUUUUAGACAGAUGUUUCCCUCCUUUGCCAUUUCUCUUUUCUUUCCUCCUCUGCUCCUCUUAGUGUCCAGACAACCUUCAUGGAAGUCCUUGGGGUGGGUGGGAAAUGAGGACGGCAGGUUUCAUUCUAGGUAUAGCCCUUUGAGGUCUAACUUAAUGCAGAGAGAGUUUUCUGGUCUAUGUGCCACCUUACAUGGGAUCUUGAGCCUUGAUUUCUAAACCCCUUGCCUUUGAUGUUUCAGAAUUGAAGCUUAAAUUUGCCAACAGGCAAAUGUCCUCAAGGCAAAUUGGCUUAGGUGUUCGAUAUUCUUCUUACCAGAAAGGUAAACUUGGGUUUUUUACUUCACCCAGGAUUUGGCAUGACAGUUCCCCAUUAUCUUGUCAGCUUAGUGCUUUAAGUGAUUGCAUUUAAAAAAAUUCUGCAUUUUCAGUUUUUAGCAGGAGGAAUGGCCUCAACUAGUGGUUUUCAACUGGGGAUGAUUUUUUUCCCCUAGGGGACAUUUGAUAAUGUUUGGAGAUGUUUUAGUUGUUAGAACUGGGGUUGGGGGAACUACUGUCAUCUGGUGGGGAGAGACCGGCAAUGCUGUUGAUCUUACUAUAAUGCACAGGCCACCCCCAACAACAAACAAAUUACAUAGCCCCAAAUAUCAAUAAUGCCAAGGUCCAAAUAACCUAACCUUCCAUUACUGAAAAUAGAAGUUCAAGAAGAUAGUUUAUAAUUUAAAAAUUUUUAGGUCUUAAUAAGUUGUCAUACUUUCACAGGUUUUAUUUCAUACUAAGUAAUUUAUUUCAAAUUUUACAUUCCAAUUACAGAAAAUUUUCUAAGCCAGUUUUUGUUCUUCAUGAGUAUUACUAUCAAGGUCACAUUUUUCAUCUAGUAUGUUUUACCCUGGUACUUGUUGGCAGGGUCAGGACUAAGGUGAGAUGCGCAAGGCAUUUGCCUCACACAAAAUGCACAAUGAAUAAAAUGUCAAAACUUUAAAUAAAGACAGAAUCACUAAAAGUACUUUGCCAUAUUGGAACCUGAGGCAAAAAGAAAAAUAAGUAAUAAUAUUUAAAAUUUUGAUCUCUUGUUCAUUGUAGAUUUUUACAUUAAUUUUGAUUGUUUAAAACAUUGCAUUAAAAUAUUAUUUAAUGUGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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