BACH1-IT2: BACH1-IT2 is a long non-coding RNA (lncRNA) that has been identified as one of the ten lncRNAs with prognostic value in soft-tissue sarcoma (STS) [PMC5655202]. The risk score generated from the 10-lncRNA signature includes the expression of BACH1-IT2 [PMC5655202]. BACH1-IT2 is one of the six lncRNAs associated with a severe prognosis in STS, along with RP11-560J1.2, AP001432.14, RP4-665J23.1, RP11-230G5.2, and RP11-504A18.1 [PMC5655202]. However, due to the absence of valid probe sets for BACH1-IT2 on a specific platform, only six out of ten lncRNAs were presented in the study [PMC5655202]. BACH1-IT2 has also been implicated in sepsis and its potential role in influencing target gene expression through competitive binding to has-miR-3188 has been hypothesized [PMC9707798]. The specific role of BACH1-IT2 and other lncRNAs in sepsis progression is not yet clear [PMC9707798]. In a large-scale genomic analysis conducted on STS patients, BACH1-IT2 was identified as one of the six lncRNAs associated with a severe prognosis [PMC8233868]. References: [PMC5655202] - Liu YR et al., "A prognostic analysis for soft-tissue sarcoma patients based on long non-coding RNA-associated competing endogenous RNA network." Sci Rep. 2017 Sep 29;7(1):7988. [PMC9707798] - Liu Y et al., "Identification and validation of key lncRNAs in sepsis-induced acute lung injury." J Cell Mol Med. 2020 Dec;24(24):14476-14487. [PMC8233868] - Zhang J et al., "Identification of a 10-lncRNA prognostic signature based on genome-wide copy number alteration analysis in soft tissue sarcoma." Aging (Albany NY). 2020 Dec 10;12(23):23987-24006.