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Homo sapiens (human) HMGN3 antisense RNA 1 (HMGN3-AS1) URS000075B2F6_9606

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HMGN3-AS1: HMGN3-AS1 is a long non-coding RNA (lncRNA) that has been identified as a potential prognostic marker in uterine corpus endometrial carcinoma (UCEC) [PMC9372539]. Univariate regression analysis on a training set revealed that lower expression levels of HMGN3-AS1 corresponded to higher overall survival (OS) in UCEC patients [PMC9372539]. Additionally, HMGN3-AS1 is the host gene of HMGN3, which has been implicated in glucose homeostasis and glucose-stimulated insulin secretion [PMC10010006]. In the context of UCEC, HMGN3-AS1 is one of the five hub prognostic lncRNAs (along with LEMD1-AS1, AP000880.1, AC244517.1, and AC011466.1) that are deeply involved in the pathological processes of UCEC [PMC9201290]. These five lncRNAs were used to create a robust risk signature that can serve as an independent clinical factor for UCEC [PMC9201290]. The risk score formula for this signature includes the expression levels of HMGN3-AS1 as one of the contributing factors [PMC9201290]. Overall, these findings suggest that HMGN3-AS1 may have potential prognostic value and could be used as a clinical factor for assessing UCEC patients' outcomes.

Genome locations

Gene Ontology annotations

Sequence

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AGUAGUUGGUGUCCGGGGCCUGCGCAGAAGAGGACAGUCCGCAAGGGGCGGAAGACAAGACAAAAAUGACUCCAGUUCGCUAGACGCGCAGAGGGGCGGAUAGCGCGCGGACCCCGCCUUCCCCAACCGAGUGUGGGUUCCAGUCGCUGGGGAGGACCUGGUGGCCCCCUGACCUUGGACGAGCCAUAUUGGACGCCCCGGCGCCGUCCCGUCUUCCACGCUGCCAACUCCACCGCUCCCGCCCCGAACUGCGGCCUAGGAGCCACCGCAGCGCACCCAGCCCGCGAGUACAGCCGCAUGGGAAUAAUCCCAACAUUUGCCUGAUUUAUUUUCUUCCCUCUCCUUACGCUUGUACUUGUUUUUCUCCUCUCGCUGUUUUCCCUUCACACUAAUUCGCAACCUGGCAGUUUGCAAAGAGGAAACUCCCUUUCGGAAUGGAAAGCCGCUUUUGCUUCUUGUUGUUGGGGGUGGAAAACAUUCCAGCGAGAAUGAGUUCAAAAAGAAGGGAAACCGCGUCACUGGAGAGAAAGUAACAUUAAGAGAUCGAUGAGGACGGAGUGGGUAGGGGGGACAGAGAGAGGAACGUCUGCAACAGGCAUCUAAAAACAAGCGUGGAGGAGCAAAGAUUCCCAAUCCCCGGGUUACUACCGCGCGCGUUCUGCGCGAGCCAUUGCAAUGCCAGCAUUUACUGUAAGCAGAAUUUGAAGGCUUUUGAAAUCUUUUUUUGGUAAGACUUACCUUUCUCUUCGGCAUAAUGACUAUGUCGGUGAAGCAAAAAGUAAAGCAACGGACUGGAACUGCUGGCGCCGCCGCUGGAUGCUGCCUCUGCCUCUGCAGCUGCUCACGCGCAGGGCACGACGUAGCCCGGCCUCUUCGACCUGCACCUCCGCGGCUCCCUCUGGGGGCCCUCUGCUCGCCUCCCUGCUGCUCCAAUGAGGAGCCCCGCCAGCCGGCCGCGAGGCCCCAUUGGCUGAGGCAACGUUCUAAAUUCCACGAGGGCACGCCCACCUCCGCGCGCGGUACGCGCUGUUGUAGUUUCCACUUCACCGAAAAAAAUCUGCCUGGCGACUGAGCAUGCCCAGUUCAACUAGUAGCCUCCAGGCCACACAAUCCUGAAGUUUCAUUGUUUCGCUGCUCUCUCUUUGAGAUUGUAAGAAUAAGAACAGUGUGUGUCUUCAUAGGAAGGAAAAAGAGUAAGAAUGAAUACGUAAACUUUAUAAUGUAAAUAUAUACACAGCAGGUACCUUAUUCAUUUCCUACCCAUAAAGGCUUUUAAUGAAUGUUACAUGGUGGGAAUCUGUAAAGCGUGGGAAGGUACUCUGUACUGGAAGAGCGUGGCAACUUCUAAAGGCCUCAGUUUCCCCCCCUAGAUAUAUAGUGACAACAGUCCCUAAAAUCACUUAGCUCUAAUUUUCUGAAAUCUGUGAUUAUAAAUCACUCACUAAUUCAGCUAACUUCAAACUAGAUGUGAAGACGAAUAGGACAUGUUUGUUACGGAAAUUAGGAAAAGAAAGAACAAGGCAAAAACUGAUUAUUUUAUAUUUGAGACAUAUAUUUGAAUGACACCCGUCAUGUUACACUUUAUGCGUAAUAUUUCUCAAAGUUCUGCAAGGCAUAAAAUGAGCAUUGCAAAAAUAUUUCUGAAUUCAUUUUAUGAGACCAGAUUUACUCUGAUACCAAAACCAGUGAAAGACUUCAAAAGAGAGUUACAGACCAAUAUCACUCAUAAACAUAGACACAAAAGUCGUGAACAAAAUUUUAGUAAAUGAAACUCAACAACAUUUAAAGGGACAAUACAUCAUGACCUGUGGGGCUUAUCUUGGGAAUGCAAAGCUGCUUUUUUAAUAUCUGAGAAUCAAUCAAUGUAAUUGGCAGGAUUAAUAGAAUAAAGGGGGAAAAACAAUCCUUUCAGCAGAUGCAGGAAAAGCGCUAGUGAAUGGGUAAGCAAAUUGUGAUGAGCACAUGCAGUGGAAUACUAUUCAGCAAUAAAAAACAAUAAAAAAUUUUCCUACAUGGAUGAAUAUCAAAAACAAAGUGCUGUACGAAAGAAGUCAAAUACAAAAGACCACACUGAAUGAUUGCAUUCAUAUGAAAUUAUAGAAAAAGCAAAAUUGGGCAAAGUUAGUUUCAGAAUCAUCUUAGCAGGCAAAGCUCACAUCAUAGGAAAAUGUGUUGAAGCCUUACAUUACAAAUAUGGCCAAAUCCACUUUGGUAACACAGAGGCUGCAAAUAUGUAUUAAAAAUAUCAUGUAUUAAAUAUGUAUUAAAAAAGCAAUGAAGUUUAAUAUUUCACUUUUUCUUUAGUAAUUUUCAGAAUACAUUAAUUGAUCUAGUACUCUCCAGAGGUGGUUGAUUACUUUCUUUUUUGGAACAUCUUUAUGAACUCAUGGAUUUUUACAUAUUUGGUGUGCAUCAGUGUAUUGCUAUCAUUAUUAUUACCUUUUUAAUGCUCCUAUUACCACAUCUUUAGCCAAUGCAUACCCUUUCAAAUUAGUGCUUGUGUCCUUUUGACAUGAUCUUAAUCAUUUUUGAUAGAUUCCCUGUUCUUGGGCAUUCAGUGAAUGACAAUAGUAUACUGAAACGAAUUAAGAUAAAAACCAAUUGCUUAGAGCUAGAUAAAAAUUUACAAGUUAAUAAUUUUAUCAUUAAAAUAAUAUUUAUAAUGAAGAUGUCUUUCAAGAUAUUAAUUUGCCAAAUACUUGAUAGUUAAAUAAAGAAAAAGUCAGUGAAAACAUUUUUAGUAAGAUAUGUGUGAGAAGGAUACUGAGUAGCACUUGCAAUCUGGACUGGAUGGCUAUUUUUCUUCAUGGAGAUGGAAAGGUGCCACAACAAAGGUAGUGCUAAGGUGAAUAUUUCUCCUCUGUGAUGAAAAAUAACUCACAAAAUUGGCUUCUUUGUUAAUUUUUUUUCAAAACCAAACACUCAGAUCAUCAACAGCAAACAAAAUUGUGAAUGUUUUUACUGCACACAAUAAAAAUGCUACGAUGAAAUUG

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