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Homo sapiens (human) CDKN2A antisense RNA 1 (CDKN2A-AS1) URS000075B2D1_9606

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CDKN2A-DT: CDKN2A-DT is a long non-coding RNA (lncRNA) that has been implicated in various cancers, including hepatocellular carcinoma (HCC) [PMC7377850]. However, its specific functions and mechanisms in HCC are still not well understood and require further investigation [PMC7377850]. CDKN2A-DT has also been identified as a protective factor in head and neck squamous cell carcinoma (HNSCC) patients [PMC9213787]. In HNSCC, CDKN2A-DT is one of the genes with the highest copy number alteration frequencies [PMC10045452]. Bioinformatics analysis has predicted a binding site between CDKN2A-DT and SOSTDC1, suggesting a potential interaction between these two molecules [PMC8265817]. Furthermore, CDKN2A-DT has been identified as a potential biomarker for unfavorable outcomes in lung adenocarcinoma (LUAD) patients [PMC9712781]. In LUAD and HNSCC tissues, the expression of CDKN2A-DT was found to be downregulated compared to normal tissues [PMC9712781]. Additionally, CDKN2A-DT is one of the five lncRNAs included in an optimal prognostic signature for LUAD patients [PMC9712781]. In cuproptosis-related studies, CDKN2A-DT was identified as one of the lncRNAs associated with cuproptosis-related genes and was included in prognostic signatures for various cancers such as ovarian cancer and hepatocellular carcinoma [PMC9815527] [PMC9356288] [PMC10054813].

Genome locations

Gene Ontology annotations

Sequence

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UUUUAUGUUAUGUGGCGUGUACCCUAAAAAAAAAAAUAGAGGUGCAGUGCUCCAGCACGGGAUGAGGCAGCGUGGACAGGAGCAUCUCCCAACCUCAGUGAAGUCUGAGCCGCGUGCCUGCAACAAUCCCACUGUGGCAGAGAACCGCAGAGUUCCUUCCGGUUUGGCAGCAGUCAUUCGCAACCUCACAGCCCUCUGGAACCCCAGCCUGGGGGUCUCAGAACGCCGAGGCGGGGACUGGGAGCCGAGUCGGAUUCCGAGACUAUGGGCCAGGGUUGGCUGGAUUCAGUUACCUGGCUGAGGCCUGGUGAGCAAAAUAUCCCAAACCUCGCGUGAUCUGGAAGGGGAAGCCGGAUAAAUACGGAUCUCCAGAUGUGCCAGUCUCGAGUCUAUCGAUAUGAGGUCCCCCUAGAGUUUCUAUUCAUCAUUUUAACCGCAUUUCAUCGAUCUUGAGACACGGCUUUUGAUAUUUUAUCACCUCAAGAUAAAUAGUGUUAGAUGUCUAAUAGCAGCGUUUUUCUAAGAGAUACAUGAAACAACAGUGUCAGAAACGAUGCUGUCUUCCAUGCGAUGAAAUUGUUGUAAUAGGUGCUCAAUAAAUGUUGACAAUAAAUGA

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Publications