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Homo sapiens (human) lncRNA upregulator of antiviral response interferon signaling (LUARIS) URS000075B2C7_9606

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LUARIS: LUARIS (lncRNA upregulator of antiviral response interferon signaling), also known as lncRNA #32, is an IFN down-regulated lncRNA that is widely expressed in various human tissues [PMC6060254]. It has been reported to inhibit the replication of EMCV, HBV, and HCV [PMC6060254]. LUARIS interacts with ATF2 (activating transcription factor 2), a transcription factor that regulates the expression of several genes involved in anti-apoptosis, DNA damage response, cell growth, and inflammation [PMC7139329]. LUARIS is highly induced by pI:C and IRF3 activation but inhibited with IFNβ treatment [PMC7139329]. Binding to LUARIS is required for ATF2 interaction to a cAMP-responsive element located in the intron of IRF7 and IFN-independent ISG expression [PMC7139329]. Mechanism studies revealed that the function of LUARIS may be associated with heterogeneous nuclear ribonucleoprotein (hnRNP) U and ATF2 [PMC6060254]. It has been suggested that LUARIS may be negatively regulated by IFN to prevent excessive IFN response-induced inflammatory damage [PMC6060254]. Knockdown of LUARIS by siRNA led to a reduction in ISG expression levels [PMC7264421]. Furthermore, overexpression of LUARIS led to suppression of replication for several viral pathogens including HCV, indicating its role as a positive regulator of the IFN response [PMC5820368][PMC7503479][PMC6355698][PMC6101671][ PMC8914027].

Genome locations

Gene Ontology annotations

Sequence

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CAGCCUUCAUGAAGAGCCCAUGGCAACUCUGUGGGAAUCCUUCCAGCAGCCCGCUUAUGGCUGGAGACAGAGGUGUGGCUUCUAUCUAAGCUUUUCCCUCUGACUCAGUCCAGGAGGCAACUGUCUUGGGAAGCAAAUGAUAACAGCAUCUGGGAGAUUCUCUUCUGGAUGGACUAGCAGGGAAUCAGGACAUGAACUCAGUGGACUAACUGCACCGAGACUCACCUGGUCAUUACUUGAAGGUCAUUACUUAAACCUCCAUGAAUCUCCUGAUGAACUCCCUCAGAAGGUGGAAGGAGCACCUGACACCGACCCGAGAUCAGCAGCAGCUACGCCCACGCUGUGGGCAGUUAAGAGGCAGCCAGUGGUACCAGUCGUGAGCGAUCAGAUUUGAGGACUCAGGAUUCUGGUUUCCUGAGUGUCAUGGACCUGCGGGCUGCAGAAAUGACAGCGACAGGUCUUCAGGCAGGUGCCACAGCACCCACACACUGCCAGCAUUUUGUGCAAAAUACCCAAAGCCACAUCACCAGAUCUGGGCUCUCCUAGCUUCCCUUUGCUAAAAUGCUGGCCAAAGAGCUUAACGAGCCACUCAGGGGCACAAGAUAGGUGAAACCUGCAUGUUUUGUUUGUUAAACUAUUUGCCACAUGGCACAAGAAAAUAACAAAAAAUAAACAAAAGGAAUAACUGCAGCAUCAUGGUUUUGUUAAGAUGUCCCAAAGCUGAUCAGGGCUUCCUGUUGAAAUCUAAAUGAGACUCUUCCUAGGUGGCUUACAUUCAGUCAGCUGUGGCUCUGUGCAAAGAAAACCAGUUUCCCUUGCUCAGAAAUUUGGAGCCACUGAUAAGAGAAGAAAAGUGUGAUUCCACAUGGAGGGUCAUGAUACAAUCUGAUCUCUGACCCCGUGGAGGUGAAGGGGCUUGUUCUGCAUGCCAGGCUGAGGACUCUCGGGACUGAGGCAUUCAGAGUCGCAGCUUUAAAUCAUAAGGGUUCCCUGCCCAUUUCAUCACAAGUCAGCAGCAUCCAAAGAGUGGCGUUGAAGAAAAUCUCAUCACCGUGGGCUCAGUUUAGAUUGCUAGUCGGCUCAGAAAGCUACCUGCAAUUGCGUUUCCAGGAUGCACCACAAAUACUCUCCACAUGAGGGAGAACAUCAGUGGAUGAAACUCAGCAUGCUUAGUGCGGGGCCAAGUCCUCUAACAAAGGACACAGCGGUUAACCUGCAUUUCGAGGACAGGCACUGUCAAGCCCUCAUCAGGGAUCCAUCCAGAGAACUUUGGUAAUUCUUGCAAAAUCCCUGUAUCACACAAUUUCCUUCCUUAAUGUGAUGAAGUGUAACGGACACAUCUAUAAAGCUUCUUCAGUCCUGCAAUGCAUAGAUGAGCAGAAGGCCACAAAGCCAGGUCAUAGCACUCUCUACCAUCAGAAUGGAGCCUGCCUGAAUGUGAGCUCAGUGAGAGGCAGAUUCCAUUCUUGGGCCCGUCCACGGUGACUUGUCUGCUCUGCUCCAUCAUCCACUUAUUCACAAGUUCUGGGGCAACAAAGGGCACGUUUUGUUUCAUCUUGUGCCAAACCCUCGAUGUGUACUCACUCACUCUACCUCAUCUCAAGAACUUCAGGGCUGGGAGUGCAUUUGGAGAGAAGGCAUGUGCAAUAUCUGGAAGCCUUAGCACAGGUGGGUUAUACUGAUGCUCUAUAGCCAAACUAUAGGAACUUGGGUUCUAAGGCCAGCAGGCCCAGGUGUCACCCCAAUGGCUCCCUUCAACAGCAGCAUAAAUAAGUCAUGUCAGAAGAACUCACAUUAGCCAUCUCCAGGACUCAUUUCCCUCUCAACAGCAGGAGCUCCUGCAGUCAGAACAGCGGUAAUUUUCAAAUCAGGCAUGUGGUGAUGCAGCAGGAAAGUGCCUGCAUCCCAGGUGUCCCAGCAGCUUUCUGGAGACCUCUAAUACCCACAUCUGCACCACAAAACUGCACAGCAUUGAGUGAUACCAAUCUUCUUAUACAUAUAGGUAAGUGGUAAUAGAAUGCCUCAACAGCAGACCACCCAGGAACCAAAGACAUACUGGAUUUUCAAGUCAGAAGAAUGCUUAGAGAUCAUCUGACCCAAUAGCCAUAUUUUACAGUAAGAUGCAGAAGCCAGUGUCCACAGUGCUAAAGCCACUGGUCCAAGGUGAAAGAAUUUCAAACCCAUAAAUACCUCCAAGAAGCUUCCACUGGGACCCUAUGAUUUUAGUAAAAUUAUCAACAUUCAUGACCUAUGUCUACUGAUCUUAGCGUCUUCUCAGUAGGCAAUUAUUCUUUCUCACAUCAAUUUGCAGUUGCUAUAUUAUCAGCAUCCUUGGUAAAUCCAUCUUGUGUUCUGGGUGAAGACUAACAGAUUCUUCCUUCUUGGACUCUGUCAUUCACUCUCAUCCCUCAUAACAUCUGGCCACUGCUCUAAACACAGUGGCCUUUGAGAAAUGCUGCUGAAUUCUGACUAAGAAAGAGGAGAACUUUCAAAUACAAGAAAGUGAACAUUAUAGAGCUUACCACUCAAGAUGGUUUUCUACAAAUGCGGACAUGGGGCUGAUCUGCACCGUGUAAGUAUCAUUUGCCGAGUACUCAAAGAGUCCAUAGUAAGGGUUGAAGAGCUCCUGAGACAGAAGGAAGAAGAACUCCCGCGAGGGGCCACUGUAGUCCAGGCUGCAAAGAAAGCAGAGGUCCAGGAAGCUCAUUCUGUGCCCGGAGGUGGGGGGACCUGUUUGCACCCAGAUUCUAGUGUGCCCUUUCAGAGUUGGGUGCUGGGGAAAGCAGAGAGCAGCCUCUGCUCUUUGGAGUGAAUGCCAAUGGCAGCAUCAAUUUGCUGUAGAAAAUGAGGAUGCAGUAAUUGGUUUGGAGAUGUUUCUUAACCAGAUGUCCAUGAAUAAACUCUUAUGGCAGCUUUAAAAAAAAAAAAAAAAAAA

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