v24

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Homo sapiens (human) KCNQ1 downstream neighbor (KCNQ1DN) URS000075B205_9606

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KCNQ1DN: KCNQ1DN is a noncoding RNA gene that plays a role in restraining renal cell carcinoma (RCC) progression by regulating the transcription factor c-MYC and its downstream targets cyclin D1 and p27 [PMC10034124]. KCNQ1DN is part of the imprinted domain 2, which is relatively long and includes three noncoding RNA genes (KCNQ1OT1, KCNQ1-AS1, and KCNQ1DN) as well as approximately 10 protein coding genes, such as KCNQ1, CDKN1C, SLC22A18, PHLDA2, and OSBPL5 [PMC7262774]. The imprinted domain 2 encompasses a region of DNA that is inherited from only one parent and has been implicated in various biological processes [PMC7262774]. The specific role of KCNQ1DN within this imprinted domain is its involvement in regulating RCC progression by modulating the expression of c-MYC and its downstream targets cyclin D1 and p27 [PMC10034124]. This regulatory function suggests that KCNQ1DN may have potential as a therapeutic target for RCC treatment. Further research is needed to fully understand the mechanisms by which KCNQ1DN exerts its regulatory effects on RCC progression.

Genome locations

Gene Ontology annotations

Sequence

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GCUGCCCGCACGCCCCGACGGGAGCUGCGCCCAGCCUCCCCUCUGGAGUCGGCGCUCCAGGCUGCUGCCCGGCCGGUGGCCAAGGCCCCAGCACCACCGUCCCUCCUGCAGGGCAUCCAGCACCUACCCUUCCACUGGGCGGCUCCUGGUUCUGGUCCCGGCUGGCUCACUCAGGCUGCCUUUGGACCAGAUUCUUGAACUUUUCCACCAAGGAUGUUGCUGCUGUUUGUAGCGUCGGAUCCUGGAAAAUCGCUGUGUUGGGGAGCAGCAGGCUCUCCCUUGCUCCCCCAGGGCCUGGGAAAAUCAACCCACCUCUGCCCCCCGACCCCAGGGCUGUAACCUGGUGUCUGGUAGCCCCACUGUGAUAAACCGAAGCCCAGCACAGUUUGGGACUCGCCCCGAGUUGACUUAUGCAGCCCCCAGAACAGAGGCUGAAACCCGGCGCAUCCUGGUGAAGCCACACCCAGCCGGCCUGGUCCCAGGCCCCGGGCACGGGGUCCCCUCCACUCCCAUCUGCUUCCCUUUCAGAGCCGGGGCUGAGUCGGCAGGGACGCAGGCUCAGGGCCCUGGAUUCCCGCUUUCUGGACACUUGCGUGCAUGCCCAGCACCAGCUCGCCCUUCUGAGAAAGCAAUCCCUCCUCAGAGGGGAGAAGCCGUGGCUGUGAUGGGCAGGAAGUGGUCAGGACCCACUGCCGAGCACCAACUCCCCAUGCCACCACCAGGGGUGCGCCUGGACUCCUGGAAAGGGGUCGCGUCAGGGUGCAGCCCAUCAAAGGCUUCCCAAGAGGCAAGAGGCAAGGAGAAGUGUCCUACUUUAAACGGCCAGCCUCAGUGGUCGGCCCUGUUCACUCUGCCACCUCAGAGAGAGUGAACCCAGCAGAGGUGUGACGGGAGGCUGGGGAGAGACCCCAGCACCUUGAGCACACAGGAGCCAGGAGGAGCCCAACAGAGCAGCAGGGGCUGGGGUCUUCUCCUGAAGCCUGACUCCAUGGGACCCCAAAGAAGCAGAUGGAAAACUGAAAAAGAAAACCCCUCAAGUGAGCCACUGGAAAGAAAGCAAAACAAGAGAAAAUAAAUGAGUUGUUUGACAUAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications