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Homo sapiens (human) microRNA hsa-mir-1205 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-1205 precursor URS000075B1EF_9606

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MIR1205: MIR1205 is a microRNA that is duplicated in two cell lines, Focus and HCC-LM3, and is located in the PVT1 locus along with other microRNAs such as miR1204, miR1206, and miR1207 [PMC2739276]. Overexpression of MIR1205 has been shown to significantly decrease colony formation in Focus and HCC-LM3 cells [PMC9834419]. These findings suggest that MIR1205 may play a role in the carcinogenesis and invasiveness of human gastric cancer [PMC9834419]. Coamplification of MYC and PVT1 has been associated with rapid progression of breast cancer and poor clinical survival [PMC2739276]. A cluster of miRNAs, including MIR1204, MIR1205, MIR1206, MIR1207, and MIR1208, has been identified within the PVT1 genomic DNA region [PMC4172193]. The regulatory functions of these miRNAs within the MYC-PVT1 locus are complex [PMC4172193]. Knockdown of circRASSF2 has been shown to enhance MIR1205 expression while restraining HOXA1 expression [PMC8806576]. Pvt1 generates a diverse assortment of alternatively spliced RNAs as well as multiple microRNAs including miR1204 and MIR1205 [PMC6160183]. The potential roles of these lncRNAs as biomarkers and therapeutic targets are being explored in gastric cancer research [6–9].

Genome locations

Gene Ontology annotations

Sequence

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GAAGGCCUCUGCAGGGUUUGCUUUGAGGUACUUCCUUCCUGUCAACCCUGUUCUGGAGUCUGU

Taxonomic tree

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2D structure Publications