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Homo sapiens (human) LOXL1 antisense RNA 1 (LOXL1-AS1) URS000075AECF_9606

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LOXL1-AS1: LOXL1-AS1 is a long non-coding RNA (lncRNA) that has been found to play a role in various types of cancer, including laryngocarcinoma [PMC7552551], osteosarcoma [PMC6488861], liver cancer [PMC8258629], prostate cancer [PMC6040304], glioblastoma [PMC6965509], medulloblastoma [PMC6965509], cholangiocarcinoma [PMC9073009], and breast cancer [PMC6965509]. In laryngocarcinoma cells, LOXL1-AS1 functions through post-transcriptional control [PMC7552551]. High expression of LOXL1-AS1 is correlated with Enneking stage distant metastasis and histological grade in osteosarcoma patients [PMC6488861]. In liver cancer cells treated with glucose, LOXL1-AS1 silencing significantly inhibits glucose uptake [PMC8258629]. Silencing LOXL1-AS1 has been shown to inhibit cell proliferation and cell cycle progression in prostate cancer cells [PMC6040304]. LOXL1-AS1 expression is associated with poor prognosis in TET patients and downregulation of miR-525-5p in TCGA data analysis [PMC9073009]. The migrative ability of LOXL1-AS1 has not been verified in animal models yet [PMC8973666]. In breast cancer patients, the expression of LOXL1-AS1 is examined and found to be associated with tumor progression [PMC6965509]. Overexpression of lncRNA LOXL2L-AS sponges miR7085p leading to increased migration and invasion of breast cancer cells [PMC9852779]. LOXL1-AS1 can be a potential strategy for drug-resistant prostate cancer patients [PMC8187453]. YY1 expression mitigated by LOXL1-AS1 knockdown could be rescued after miR-3614-5p inhibition or YY1 augment [PMC8645132].

Genome locations

Gene Ontology annotations

Sequence

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GCACCGGCAGGUAGGGCGGCUCCAGCGCGCGCGGCGGCCCGUACGCCUCGGGCGGCGGGUUGGCGUAGGGCGGGUACCAGCCCAGGCGUGGGUCUCCGCCAUGGGCCUGCGCCGCCUCGGGACCGGGGUCAGGGUGCCACGGCUUACCAAUGGAAGAUUAGGCCAGAUGGCUCCUGAGAGUGCUUUGGGAGAUUCUCUGUUCCUUCUGGGAAUGGCAGGGAUAGGAGGGGGUCCCAGAAGUUUGAACGCUUUGGCAUCCAAGAAAUCACACUCCAAAUACUGCUCUUCUGGCCUCCCCUGGGCUGCCUUCUCCAACCGUGUUCCUGGGAACCGAAGGGCAGAAAUUGCCCUCUUGGGCUUAUAAACAAGGAGCUCCUGCCUGCCUGGAUGAAGAGGAGGUCAAGACUUUGUCCCCCACUCCGCAAGAUACCCUCUCUGUUCCGGAGCGGUGGGUCCCUCCCCUGUUAGGACCUUGUCUCCCUCAGGACUGGACCUGGAUCCUGGGCCUGCAGUCAGAUUGCCAGUUUCACUUAGAGGUGGAAAUGUCAACCCACUGGUUGGAAUGGGAAGGUGAGACAGGAUUUCACCAUGUUAGCCAGGAUGGUCUUGAUCUCCUGACCUCAUGAUCUGCCCACCUCGGCCUCCCAAAGUGCUGGGCUUACAGGCGUGAGCCACCGUGCCCGGCCAAAAAUAACUUUUAAAAACAUGAGUAUAGCAUACACACACACAAAAGUCCACAAAUCCUAGGUGUACCACUUGAUGAAUGAUCCCAACGUGAGCACACCUCUGGAUUACCACCUGGAUCAAGAAAUAGGACAUCACAGCAGCUGGCAGCUUCCAAGGAGAAGCUCUGGAAAGUUCUGCCUGUCUCAGCACCUGGCUGGAUCGGAAACGAGUUUUCUUUAACCAGAUUUUUAAUGACUGACUUAUGUGGACAAAUCAUAACUGAAUGAAUCACCUCCUUUGUUGAUUUUUUUGGGUACUUUAUUUGCUAUUAUAAAUGAUGCUGUAAUAAGCACCCUUGAAGAAAUCUUCAUAUCUGCCUCUCCUGUGUAGCAGGUCACAGUGCCUGGGUUUGGUUCUAGCCCUCAUUUGUGAACUGUGUGACUCACCAUGCCUUUUUUCUUUCUGUAAGACAGGAAUAAUGGUAAGAAUUUAAAUGGGGGUAAUAUGGAGCGCGUUUAGUUCAGAGCCUGGUGCAUACAAGCACUCAAUAAGUACUGGCGAUUAUUAGACCUUUAGAUUAAUUUAUUAGAAGUUGGAUUUCUGGUGAAAGGGUUUGAGUGUUUUUGAGGCUUUGGCACAGAAUACCCAGCUGGUCCCAGAAAGGUGGUUCCCAUUUACCUGCCCGAAGGUAAUUCACCCUUACUGAUACUGAGUACUGUUUUCUAAAAGAACAUUAAAAAUUGGAUAGGUUAAAAACAGGUGAAUACAUUUUUUUAGUUGCAUUUUUUUGGUUACCCGUGAGAGUGAACAUGUUGCCAUGUGUUUGCUGACCUCCUAAAUGGUCUAUUUGCUCCUACCUUUGUACCCCAAAAGUCUGCUCUCAAGAUGGUAGCCAGAAUGAUCCUUUUUGAGACAUAAGUCAAAAUUUCACUCUUCUCCUUAAAGCUCUGCAAUGGUUCUCAGGUUAAAAGCCAAAGUCCUGUUCAAGGCCUCCAGGGUCCUCACCACUUGGUCCCUUGCUCUUUCUGUUCUAGCCAACUUGGCCUUCUCCUGCCCCUCCGCCGCACCAUGGCAAUUUCCCCUGCUCUGUGUGGUCAACUACCUGAAUCUGUUCAAAGCUUUGCUCAAAUGUCUCCUUCCUGAUGAGACCUCCCCAGCCCCUGAGCUCCCCAUGCCUCACUCCUGAUCGCCUUACUUAACCCUUCUUUUUCUUUUUUGCCAGUAGUACUUAUCACCGUCUAAAAUACUUCAUAAUUUACUUGUUUAUUGUUUGCCCCUCUCCAAUAGAAUGUAAGCUCCUUGGGGCAGGGACCUUUGUCCUUUGUCUUGUUCACUGCUGUGUCCCAUGUGUAAACUUGUCUGGCACAGAAGAGGUGCUCGAUAAAUAUUUGUUGAGUGAAUGAAUGGUAAAUUUUCUGUUCAUAUUCUUUGACUAUUUUCUAUUGUAAUGUUCAUCUUUUUAGUAUUGGUUUAUAAGAUGUAUAUUUAGCACCUUUUCAUAUAUCACUCUUUGUCACAUAUUAUGCAACUAAUUUGUCAUUUCCAUCAAUUUUUAAAAUACUUUCUUGAUGCUUCAUUUUUAAGCUGUCAGAUUAUUAAUCUUUUCUUUAUGGUCUUGGACUUUAUUGUUGCAUAACCGCUGCCUUCACCAGGAACAUAUAAAUUUUCAAUUAAAUGUUCUUCUGAGAUUUUAUGAUUUCACUUUUUAUAUUAAACUCUUCAUUUUGUCUUCAUGUGUGGUGAGAGGUAAGAACAUAACUUUAAAGCAAAUUAACCAACUAUCCCCAAAUGAAUUAUAAAUAAAUUAAUCAUUUUCCAAUAAAAAAAAAAAAAAA

Taxonomic tree

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Publications