hsa-mir-190b: Hsa-mir-190b, an miRNA, was found to be upregulated and involved in the regulation of FGF2 downregulation, which in turn alleviated the inflammatory response and vascular endothelial injury [PMC8923688]. Additionally, hsa-mir-190b was found to activate the expression of FGF2 and FGFR1 proteins [PMC8923688]. On the other hand, hsa-mir-190b and hsa-miR-449a were identified as the most significantly downregulated miRNAs [PMC7499949]. The upregulation of hsa-mir-190b suggests its potential role in modulating FGF2 expression [PMC8923688]. This regulation of FGF2 may contribute to the alleviation of inflammatory response and vascular endothelial injury [PMC8923688]. The activation of FGF2 and FGFR1 protein expression by hsa-mir-190b further supports its involvement in cellular processes [PMC8923688]. In contrast to its upregulation, hsa-mir-190b was found to be downregulated along with hsa-miR-449a [PMC7499949]. This downregulation suggests a potential role for these miRNAs in different cellular processes or pathways [PMC7499949]. In summary, hsa-mir-190b is an miRNA that is upregulated and involved in regulating FGF2 expression [PMC8923688]. This regulation may contribute to alleviating inflammatory response and vascular endothelial injury while activating FGF2 and FGFR1 protein expression [PMC8923688]. Additionally, both hsa-mir-190b and hsa-miR-449a were significantly downregulated [PMC7499949] [PMC8923688].

MIR190B: MIR190B is a microRNA that has been identified as one of the deregulated miRNAs in various studies [PMC6615718] [PMC6468970] [PMC7918779]. It has been found to be involved in multiple pathways, including the regulation of ATG7 mRNA [PMC6468970]. In one study, MIR190B was found to be one of the miRNAs that discriminate between different grades of cancer [PMC7918779]. Another study found that MIR190B demonstrated low expression levels in a specific cell line [PMC3929981]. Additionally, high expression of MIR190B has been associated with a poor response to radiotherapy in patients with rectal cancer [PMC9065280]. The MIR190B gene is located on rat chromosome 2 and is predicted to reside within a specific interval on this chromosome [PMC3339715] [PMC4263296]. It has also been found to be deleted in certain genetic abnormalities, along with other genes such as C1orf189 and TPM3 [PMC5240603]. In terms of its function, MIR190B has been identified as a neuroprotective molecule that can be transported by astrocyte-derived exosomes to protect neurons against toxic insults [PMC8393731]. Overall, these studies highlight the importance and diverse roles of MIR190B in various biological processes.